U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ospA outer surface lipoprotein OspA [ Borreliella burgdorferi B31 ]

Gene ID: 1194357, discontinued on 22-Mar-2020
  • This record was discontinued.

Summary

Go to the top of the page Help
Gene symbol
ospA
Gene description
outer surface lipoprotein OspA
Locus tag
BB_RS05180
Gene type
protein coding
Organism
Borreliella burgdorferi B31 (strain: B31, type-material: type strain of Borreliella burgdorferi)
Lineage
Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella
Old locus tag
BB_A15
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
plasmid: lp54
Sequence:
NC_001857.2 (9457..10278)

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001857.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here the authors show that the related, tick-specific protein OspB can fully substitute for OspA, whereas the unrelated, mammal-specific protein OspC cannot.
    Title: Functional Equivalence of OspA and OspB, but Not OspC, in Tick Colonization by Borrelia burgdorferi.
  2. Evaluation of OspA vaccination-induced serological correlates of protection against Lyme borreliosis in a mouse model.
    Title: Evaluation of OspA vaccination-induced serological correlates of protection against Lyme borreliosis in a mouse model.
  3. neuroinvasive Borrelia and its recombinant OspA activated CD40-dependent pathway in BMECs and induced expression of integrins essential for stationary adhesion
    Title: OspA-CD40 dyad: ligand-receptor interaction in the translocation of neuroinvasive Borrelia across the blood-brain barrier.
  4. Calmodulin fusion to truncated or mutant OspA N-terminal tether peptides were targeted to the periplasm.
    Title: Probing the Borrelia burgdorferi surface lipoprotein secretion pathway using a conditionally folding protein domain.
  5. Both OspA and Vsp1 are compatible in anchoring these surface lipoproteins in the outer leaflet of the outer spirochetal membrane.
    Title: Determination of Borrelia surface lipoprotein anchor topology by surface proteolysis.
  6. data show disturbance of confined tether feature leads to premature folding of OspA in periplasm and prevents secretion through the membrane;suggest OspA emerges tail-first on bacterial surface independent of specific C-terminal targeting sequence
    Title: Translocation of Borrelia burgdorferi surface lipoprotein OspA through the outer membrane requires an unfolded conformation and can initiate at the C-terminus.
  7. Increasing production of OspA or VlsE influences lipoprotein gene expression in the murine host and alters the infectious behaviour of B. burgdorferi.
    Title: Modification of Borrelia burgdorferi to overproduce OspA or VlsE alters its infectious behaviour.
  8. OspA serves a critical antibody-shielding role during vector blood meal uptake from immune hosts and is not required for persistence in the tick vector.
    Title: Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vector.
  9. Increasing expression of OspA fully protected the ospC mutant from elimination from the skin tissue of SCID mice.
    Title: Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences.
  10. Data did not find any evidence for glycosylation of the major outer membrane proteins OspA.
    Title: Flagellin and outer surface proteins from Borrelia burgdorferi are not glycosylated.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General protein information

Go to the top of the page Help
Preferred Names
outer surface lipoprotein OspA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001857.2 Reference assembly

    Range
    9457..10278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_010890378.1 outer surface lipoprotein OspA [Borreliella burgdorferi]

    See identical proteins and their annotated locations for WP_010890378.1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CL66.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Research Materials