Desat1 Desaturase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Desat1provided by FlyBase
Official Full Name: Desaturase 1provided by FlyBase
Primary source: FLYBASE:FBgn0086687
Locus tag: Dmel_CG5887
See related: AllianceGenome:FB:FBgn0086687
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.726; anon-WO0118547.730; BEST:SD05462; CG5887; desat; desat1; DESAT1; Dmel NPSE; Dmel NPSE Z9; Dmel\CG5887; ds1; fad; Fad; l(3)S028813
Summary: Predicted to enable iron ion binding activity and stearoyl-CoA 9-desaturase activity. Involved in several processes, including cuticle hydrocarbon biosynthetic process; mating behavior, sex discrimination; and pheromone biosynthetic process. Located in cytoplasmic vesicle and endoplasmic reticulum. Is expressed in several structures, including gonad; mesoderm; oenocyte; organism subdivision; and reproductive system. Used to study restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to several human genes including SCD5 (stearoyl-CoA desaturase 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 87B10-87B11; 3-52 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (12439600..12447616)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8265322..8273338)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our data suggest that the regulation of this dsat1 has evolved to allow the optimal reproduction and a successful adaptation to varied environments
Title: The desaturase1 gene affects reproduction before, during and after copulation in Drosophila melanogaster.
we designated the sequential prolines at the second and third positions of DESAT1 as a "di-proline motif," which plays a crucial role in the regulation of Delta9-desaturase expression in response to changes in the level of cellular unsaturated fatty acids
Title: An N-terminal di-proline motif is essential for fatty acid-dependent degradation of Δ9-desaturase in Drosophila.
In Drosophila, rk function is required for the normal maturation of the fly's cuticular hydrocarbon (CH) profile, with flies mutant for rk function showing dramatically elevated levels of CHs. This effect is mostly abrogated by mutations in the Delta9 desaturase encoded by the desaturase1 gene, suggesting that desaturase1 acts downstream of rk.
Title: Regulation of cuticular hydrocarbon profile maturation by Drosophila tanning hormone, bursicon, and its interaction with desaturase activity.
Fat desaturase Desat1 is necessary for dMyc induced systemic growth.
Title: dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth.
Distinct desat1 putative regulatory regions independently drive the expression in nonneural and in neural cells.
Title: Expression of a desaturase gene, desat1, in neural and nonneural tissues separately affects perception and emission of sex pheromones in Drosophila.
Data suggest that the pleiotropic action of desat1 on pheromonal communication depends on the fine regulation of its transcriptional activity.
Title: The consequences of regulation of desat1 expression for pheromone emission and detection in Drosophila melanogaster.
Data suggest that Desat1 exerts its role in autophagy by controlling lipid biosynthesis and/or signaling necessary for autophagic responses.
Title: A combined proteomic and genetic analysis identifies a role for the lipid desaturase Desat1 in starvation-induced autophagy in Drosophila.
A single genomic transposon inserted in the desatl gene simultaneously affected the emission and the perception of sex-specific signals, and greatly decreased the production of unsaturated hydrocarbons on the cuticle of mature flies of both sexes.
Title: A single mutation alters production and discrimination of Drosophila sex pheromones.
desat1 plays major role in biosynthesis of unsaturated fatty acids in drosophila and is also involved in affecting the availability of saturated fatty acids
Title: Mutations in the desat1 gene reduces the production of courtship stimulatory pheromones through a marked effect on fatty acids in Drosophila melanogaster.
role desat1 gene in the control of Drosophila melanogaster pheromone biosynthesis
Title: Involvement of desat1 gene in the control of Drosophila melanogaster pheromone biosynthesis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables iron ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables stearoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cuticle hydrocarbon biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating behavior, sex discrimination	IDA Inferred from Direct Assay more info	PubMed
involved_in pheromone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to sucrose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: desaturase 1

Names: CG5887-PA; CG5887-PB; CG5887-PC; CG5887-PD; CG5887-PE; Desat1-PA; Desat1-PB; Desat1-PC; Desat1-PD; Desat1-PE; desat1; desaturase; desaturase1; fatty acid desaturase; lethal (3) S028813; stearoyl CoA desaturase; stearoyl-CoA 9-desaturase

NP_652731.1

EC 1.14.19.-

EC 1.14.19.1

NP_731709.1

EC 1.14.19.-

EC 1.14.19.1

NP_731710.1

EC 1.14.19.-

EC 1.14.19.1

NP_731711.1

EC 1.14.19.-

EC 1.14.19.1

NP_731712.1

EC 1.14.19.-

EC 1.14.19.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

12439600..12447616

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_144474.1 → NP_652731.1 desaturase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652731.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K4Y0, Q94541

Related

FBpp0082095, FBtr0082626

Conserved Domains (2) summary

cd03505
Location:97 → 338

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

pfam00487
Location:98 → 305

FA_desaturase; Fatty acid desaturase
NM_169466.1 → NP_731710.1 desaturase 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731710.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K4Y0, Q94541

Related

FBpp0082096, FBtr0082627

Conserved Domains (2) summary

cd03505
Location:97 → 338

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

pfam00487
Location:98 → 305

FA_desaturase; Fatty acid desaturase
NM_169468.1 → NP_731712.1 desaturase 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731712.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K4Y0, Q94541

Related

FBpp0082097, FBtr0082628

Conserved Domains (2) summary

cd03505
Location:97 → 338

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

pfam00487
Location:98 → 305

FA_desaturase; Fatty acid desaturase
NM_169465.1 → NP_731709.1 desaturase 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731709.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K4Y0, Q94541

Related

FBpp0082098, FBtr0082629

Conserved Domains (2) summary

cd03505
Location:97 → 338

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

pfam00487
Location:98 → 305

FA_desaturase; Fatty acid desaturase
NM_169467.1 → NP_731711.1 desaturase 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731711.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K4Y0, Q94541

Related

FBpp0082099, FBtr0082630

Conserved Domains (2) summary

cd03505
Location:97 → 338

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

pfam00487
Location:98 → 305

FA_desaturase; Fatty acid desaturase