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MRGPRX3 MAS related GPR family member X3 [ Homo sapiens (human) ]

Gene ID: 117195, updated on 2-Nov-2024

Summary

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Official Symbol
MRGPRX3provided by HGNC
Official Full Name
MAS related GPR family member X3provided by HGNC
Primary source
HGNC:HGNC:17980
See related
Ensembl:ENSG00000179826 MIM:607229; AllianceGenome:HGNC:17980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR; MRGX3; SNSR1; SNSR2
Summary
This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See MRGPRX3 in Genome Data Viewer
Location:
11p15.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18120955..18138488)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18216477..18233987)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18142502..18160035)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 5 Neighboring gene serum amyloid A3, pseudogene Neighboring gene MAS related GPR family member X12, pseudogene Neighboring gene MAS related GPR family member X4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease. Franco R, et al. Prog Neurobiol, 2017 Feb-Mar. PMID 28189739
  2. GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib. Chen LY, et al. Acta Pharmacol Sin, 2022 Jun. PMID 34552215, Free PMC Article
  3. GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro. Schmid CD, et al. Biochem Biophys Res Commun, 2018 Feb 26. PMID 29408502
  4. Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype. Kaisho Y, et al. Biochem Biophys Res Commun, 2005 May 13. PMID 15809047
  5. Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs. Lembo PM, et al. Nat Neurosci, 2002 Mar. PMID 11850634

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib.
    Title: GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib.
  2. Our data demonstrate that GPR182 is an endothelial subtype-specific marker for human sinusoidal EC of the liver, spleen, lymph node and bone marrow. In addition, we provide evidence for GPR182-dependent downstream signaling via ERK and SRF pathways that may be involved in regulating endothelial subtype-specific sinusoidal differentiation and sinusoidal functions such as permeability.
    Title: GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro.
  3. Potential of GPCRs to modulate MAPK and mTOR pathways in different stages of the neurodegenerative disease.
    Title: Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease.
  4. overexpression of the human MrgX3 gene causes a disturbance of the normal cell-differentiation process
    Title: Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mas-related G-protein coupled receptor member X3
Names
G protein-coupled receptor MRGX3
G protein-coupled receptor SNSR1
G protein-coupled receptor SNSR2
MAS-related GPR, member X3
mas-related GPCR member X3
sensory neuron-specific G-protein coupled receptor 1/2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370464.1 → NP_001357393.1  mas-related G-protein coupled receptor member X3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC090099
    Consensus CDS
    CCDS7830.1
    UniProtKB/Swiss-Prot
    B0M0L1, Q8TDE0, Q8TDE1, Q96LB0
    UniProtKB/TrEMBL
    W8W3E1
    Related
    ENSP00000481943.1, ENST00000621697.2
    Conserved Domains (1) summary
    cd15106
    Location:28 → 299
    7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_054031.4 → NP_473372.3  mas-related G-protein coupled receptor member X3

    See identical proteins and their annotated locations for NP_473372.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC090099, BC067292
    Consensus CDS
    CCDS7830.1
    UniProtKB/Swiss-Prot
    B0M0L1, Q8TDE0, Q8TDE1, Q96LB0
    UniProtKB/TrEMBL
    W8W3E1
    Related
    ENSP00000379571.2, ENST00000396275.2
    Conserved Domains (1) summary
    cd15106
    Location:28 → 299
    7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    18120955..18138488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    18216477..18233987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LB0.2 GenPept UniProtKB/Swiss-Prot:Q96LB0

Gene LinkOut

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