Erp29 endoplasmic reticulum protein 29 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Erp29provided by RGD
Official Full Name: endoplasmic reticulum protein 29provided by RGD
Primary source: RGD:619781
See related: EnsemblRapid:ENSRNOG00000001348 AllianceGenome:RGD:619781
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein homodimerization activity and protein-folding chaperone binding activity. Predicted to be involved in several processes, including negative regulation of protein secretion; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; and regulation of gene expression. Predicted to act upstream of or within positive regulation of MAP kinase activity. Located in smooth endoplasmic reticulum. Orthologous to human ERP29 (endoplasmic reticulum protein 29). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 428.6), Spleen (RPKM 303.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (40750177..40756607)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (35089698..35095952)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (40619377..40625884)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin 10 Plays an Important Role in Neonatal Rats with Hypoxic-Ischemia Associated with B-Cell Lymphoma 2 and Endoplasmic Reticulum Protein 29.
Title: Interleukin 10 Plays an Important Role in Neonatal Rats with Hypoxic-Ischemia Associated with B-Cell Lymphoma 2 and Endoplasmic Reticulum Protein 29.
overexpression of ERp29 in cortical neurons after axotomy increased expression of Erk-1 and PI3K while decreasing the expression of caspase-3 expression.
Title: Endoplasmic Reticulum Protein 29 Protects Axotomized Neurons from Apoptosis and Promotes Neuronal Regeneration Associated with Erk Signal.
ERp29 was first identified as a BPA-binding protein but is not involved in the T3 response of GH3 cells
Title: Endoplasmic reticulum protein (ERp) 29 binds as strongly as protein disulfide isomerase (PDI) to bisphenol A.
ERp29 can improve locomotor function by promoting neuronal survival and axonal regeneration in spinal cord transection rats via caspase and Erk signal pathway.
Title: Endoplasmic reticulum protein 29 protects cortical neurons from apoptosis and promoting corticospinal tract regeneration to improve neural behavior via caspase and Erk signal in rats with spinal cord transection.
This supports a new role for ERp29 as a chaperone that helps stabilize monomeric Cx43 to enable oligomerization to occur in the Golgi apparatus.
Title: ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum.
lactating mammary glands were expressing ERp29 while the resting glands did not
Title: ERp29, an endoplasmic reticulum secretion factor is involved in the growth of breast tumor xenografts.
dimerization of ERp29 is crucial for its protein unfolding function, dimerization of a ERP29 protein acts to regulate its diverse endoplasmic reticulum activities.
Title: Dimerization of ERp29, a PDI-like protein, is essential for its diverse functions.
ERp29 assists in protein folding as well as in the secretion of the secretory/plasma membrane proteins under close co-operation with other ER chaperones and the ER stress signaler, PERK.
Title: Overexpression of ERp29 in the thyrocytes of FRTL-5 cells.
mutants of the D-domain of ERp29 prevent transport of a substrate protein (Pipe) in a manner consistent with the presence of a discrete, conserved peptide binding site in the D-domain
Title: Conserved structural and functional properties of D-domain containing redox-active and -inactive protein disulfide isomerase-related protein chaperones.
Results distinguish ERp29 biophysically from its peers in the ER including Windbeutel, endorsing our postulate that ERp29 adds a distinct type of folding activity to the ER machinery.
Title: Biophysical characterization of ERp29. Evidence for a key structural role of cysteine 125.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

RH129307 (e-PCR)
- UniSTS:212614

D12Rat79 (e-PCR), detects polymorphism
- UniSTS:226474

RH128633 (e-PCR)
- UniSTS:211941

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein folding	TAS Traceable Author Statement more info	PubMed
involved_in protein secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: endoplasmic reticulum resident protein 29

Names: ERp31; endoplasmic reticulum protein ERp29; endoplasmic reticulum resident protein 31; endoplasmic retuclum protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053961.2 → NP_446413.1 endoplasmic reticulum resident protein 29 precursor

See identical proteins and their annotated locations for NP_446413.1

Status: PROVISIONAL

Source sequence(s)

BC091129

UniProtKB/Swiss-Prot

P52555, P80749, Q5BKC2

UniProtKB/TrEMBL

A6J1E8

Related

ENSRNOP00000001822.3, ENSRNOT00000001822.7

Conserved Domains (2) summary

cd03007
Location:36 → 149

PDI_a_ERp29_N; PDIa family, endoplasmic reticulum protein 29 (ERp29) subfamily; ERp29 is a ubiquitous ER-resident protein expressed in high levels in secretory cells. It forms homodimers and higher oligomers in vitro and in vivo. It contains a redox inactive TRX-like ...

pfam07749
Location:157 → 250

ERp29; Endoplasmic reticulum protein ERp29, C-terminal domain