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LRG1 leucine rich alpha-2-glycoprotein 1 [ Homo sapiens (human) ]

Gene ID: 116844, updated on 14-Nov-2024

Summary

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Official Symbol
LRG1provided by HGNC
Official Full Name
leucine rich alpha-2-glycoprotein 1provided by HGNC
Primary source
HGNC:HGNC:29480
See related
Ensembl:ENSG00000171236 MIM:611289; AllianceGenome:HGNC:29480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRG; HMFT1766
Summary
The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in liver (RPKM 150.7), esophagus (RPKM 16.6) and 4 other tissues See more
Orthologs
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Genomic context

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See LRG1 in Genome Data Viewer
Location:
19p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4536402..4540036, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4520069..4523703, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4536414..4540048, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene HDGF like 2 Neighboring gene perilipin 4 Neighboring gene perilipin 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4534387-4534942 Neighboring gene semaphorin 6B Neighboring gene Sharpr-MPRA regulatory region 7851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4567569-4568069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4575301-4575893 Neighboring gene uncharacterized LOC105372249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9894

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Serum Leucine-Rich α2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis. Shimizu M, et al. J Immunol Res, 2019. PMID 30863782, Free PMC Article
  2. Electrochemical peptide sensor for diagnosing adenoma-carcinoma transition in colon cancer. Lim JM, et al. Biosens Bioelectron, 2017 Dec 15. PMID 28697446
  3. Overexpression of leucine-rich α2-glycoprotein-1 is a prognostic marker and enhances tumor migration in gastric cancer. Yamamoto M, et al. Cancer Sci, 2017 Oct. PMID 28746773, Free PMC Article
  4. Value of Leucine-rich alpha-2-glycoprotein-1 (LRG-1) on diagnosis of acute appendicitis in female patients with right lower-quadrant abdominal pain. Demirci OL, et al. J Pak Med Assoc, 2017 Sep. PMID 28924279
  5. Plasma Leucine-Rich α-2-Glycoprotein 1 Predicts Rapid eGFR Decline and Albuminuria Progression in Type 2 Diabetes Mellitus. Liu JJ, et al. J Clin Endocrinol Metab, 2017 Oct 1. PMID 28973352

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leucine rich alpha2 glycoprotein 1 derived from malignant pleural mesothelioma cells facilitates macrophage M2 phenotypes.
    Title: Leucine rich α2 glycoprotein 1 derived from malignant pleural mesothelioma cells facilitates macrophage M2 phenotypes.
  2. LRG1 and SDR16C5 protein expressions differ according to HPV status in oropharyngeal squamous cell carcinoma.
    Title: LRG1 and SDR16C5 protein expressions differ according to HPV status in oropharyngeal squamous cell carcinoma.
  3. High serum levels of leucine-rich alpha-2 glycoprotein 1 (LRG-1) are associated with poor survival in patients with early breast cancer.
    Title: High serum levels of leucine-rich α-2 glycoprotein 1 (LRG-1) are associated with poor survival in patients with early breast cancer.
  4. Relation between LRG1 and CD4[+] T cells, cognitive impairment and neurological function in patients with acute ischemic stroke.
    Title: Relation between LRG1 and CD4(+) T cells, cognitive impairment and neurological function in patients with acute ischemic stroke.
  5. Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFbeta1- Smad1/5 signaling pathway.
    Title: Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
  6. Leucine-Rich Alpha-2 Glycoprotein 1 Accumulates in Complicated Atherosclerosis and Promotes Calcification.
    Title: Leucine-Rich Alpha-2 Glycoprotein 1 Accumulates in Complicated Atherosclerosis and Promotes Calcification.
  7. Relationship between plasma leucine-rich alpha-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes.
    Title: Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes.
  8. Leucine-Rich Alpha-2 Glycoprotein Is a Reliable Serum Biomarker for Evaluating Clinical and Endoscopic Disease Activity in Inflammatory Bowel Disease.
    Title: Leucine-Rich Alpha-2 Glycoprotein Is a Reliable Serum Biomarker for Evaluating Clinical and Endoscopic Disease Activity in Inflammatory Bowel Disease.
  9. LRG1 Promotes ECM Integrity by Activating the TGF-beta Signaling Pathway in Fibroblasts.
    Title: LRG1 Promotes ECM Integrity by Activating the TGF-β Signaling Pathway in Fibroblasts.
  10. Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence.
    Title: Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence.
Submit: New GeneRIF Correction See all GeneRIFs (99)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: PLIN5

Homology

Clone Names

  • FLJ45787

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type I transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables type II transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of keratinocyte migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of epithelial cell proliferation involved in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of positive regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in specific granule lumen TAS
Traceable Author Statement
more info
  
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
leucine-rich alpha-2-glycoprotein
Names
1300008B03Rik
2310031E04Rik
leucine rich alpha 2 glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052972.3 → NP_443204.1  leucine-rich alpha-2-glycoprotein precursor

    See identical proteins and their annotated locations for NP_443204.1

    Status: VALIDATED

    Source sequence(s)
    AC011498, AF403428, AK027382
    Consensus CDS
    CCDS12130.1
    UniProtKB/Swiss-Prot
    P02750, Q8N4F5, Q96QZ4
    UniProtKB/TrEMBL
    Q68CK4
    Related
    ENSP00000302621.4, ENST00000306390.7
    Conserved Domains (4) summary
    smart00082
    Location:299 → 346
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:82 → 248
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:94 → 117
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:116 → 176
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4536402..4540036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4520069..4523703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02750.2 GenPept UniProtKB/Swiss-Prot:P02750

Gene LinkOut

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