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Rims1 regulating synaptic membrane exocytosis 1 [ Mus musculus (house mouse) ]

Gene ID: 116837, updated on 2-Nov-2024

Summary

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Official Symbol
Rims1provided by MGI
Official Full Name
regulating synaptic membrane exocytosis 1provided by MGI
Primary source
MGI:MGI:2152971
See related
Ensembl:ENSMUSG00000041670 AllianceGenome:MGI:2152971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rim; RIM1; RIM1a; Serg1; Rab3ip1; RIM1alpha; C030033M19Rik
Summary
Enables transmembrane transporter binding activity. A structural constituent of presynaptic active zone. Involved in several processes, including neurotransmitter secretion; regulation of calcium-dependent activation of synaptic vesicle fusion; and regulation of nervous system process. Acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter; regulation of long-term neuronal synaptic plasticity; and regulation of membrane potential. Located in inhibitory synapse; postsynaptic density; and vesicle. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Is extrinsic component of presynaptic active zone membrane. Is expressed in brain and cerebellum. Orthologous to human RIMS1 (regulating synaptic membrane exocytosis 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 23.6), frontal lobe adult (RPKM 17.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Rims1 in Genome Data Viewer
Location:
1 A5; 1 8.54 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (22356196..22845239, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (22285972..22806158, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily Q, member 5 Neighboring gene STARR-seq mESC enhancer starr_00411 Neighboring gene STARR-seq mESC enhancer starr_00412 Neighboring gene predicted gene, 53539 Neighboring gene STARR-seq mESC enhancer starr_00414 Neighboring gene transmembrane emp24 domain trafficking protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00415 Neighboring gene STARR-seq mESC enhancer starr_00416 Neighboring gene STARR-seq mESC enhancer starr_00417 Neighboring gene STARR-seq mESC enhancer starr_00419 Neighboring gene STARR-seq mESC enhancer starr_00422 Neighboring gene STARR-seq mESC enhancer starr_00423 Neighboring gene STARR-seq mESC enhancer starr_00424 Neighboring gene predicted gene 7759 Neighboring gene predicted gene 7761

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons. Wang J, et al. Nat Commun, 2018 Jun 11. PMID 29891949, Free PMC Article
  2. Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses. Lonart G, et al. Cell, 2003 Oct 3. PMID 14532002
  3. Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. Calakos N, et al. Neuron, 2004 Jun 24. PMID 15207234
  4. Role of RIM1α in short- and long-term synaptic plasticity at cerebellar parallel fibres. Kintscher M, et al. Nat Commun, 2013. PMID 23999086
  5. Ultrastructural analysis of wild-type and RIM1α knockout active zones in a large cortical synapse. Lichter K, et al. Cell Rep, 2022 Sep 20. PMID 36130490

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cAMP-EPAC-PKCepsilon-RIM1alpha signaling regulates presynaptic long-term potentiation and motor learning.
    Title: cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning.
  2. Here, the authors identify an essential role for the active zone protein RIM in stimulated somatodendritic dopamine release in the midbrain. In mice in which RIMs are selectively removed from dopamine neurons, action potentials failed to evoke significant somatodendritic release detected via D2 receptor-mediated currents.
    Title: RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain.
  3. Conditional deletion of presynaptic proteins RIM1alphabeta (RIM1) from excitatory cortical neurons impairs corticostriatal synaptic transmission in the dorsolateral striatum. RIM1-dependent processes help to promote the refinement of skilled actions, constrain goal-directed behaviors, and support the learning and use of habits.
    Title: Active Zone Proteins RIM1αβ Are Required for Normal Corticostriatal Transmission and Action Control.
  4. RIM C2B domains are constitutive PIP2-binding molecules that couple mechanisms for synaptic vesical priming.
    Title: RIM C(2)B Domains Target Presynaptic Active Zone Functions to PIP(2)-Containing Membranes.
  5. eye-specific segregation in the dLGN and topographic refinement of ipsilateral axons in the SC and the dLGN, are impaired in RIM1/2 conditional knock-out (Rim-cDKO) mice
    Title: RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.
  6. Postsynaptic RIM1 in hippocampal CA1 region is required for basal NMDAR-, but not AMPA receptor (AMPAR)-, mediated synaptic responses, and contributes to synaptic plasticity and hippocampus-dependent memory. Moreover, RIM1 levels in hippocampal neurons influence both the constitutive and regulated NMDAR trafficking, without affecting constitutive AMPAR trafficking.
    Title: Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons.
  7. Here, the authors show that exophilin-8 accumulates granules in the cortical F-actin network not by direct interaction with myosin-Va, but by indirect interaction with a specific form of myosin-VIIa through its previously unknown binding partner, RIM-BP2.
    Title: Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa.
  8. RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions.
    Title: How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
  9. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47.
    Title: C-terminal splice variants of P/Q-type Ca(2+) channel Ca(V)2.1 α(1) subunits are differentially regulated by Rab3-interacting molecule proteins.
  10. The function of RIM1/2 at rod ribbons is to enhance Cav1.4 channel activity, possibly through direct or indirect modulation of the channel.
    Title: RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0340

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of presynaptic active zone IEP
Inferred from Expression Pattern
more info
 PubMed 
enables structural constituent of presynaptic active zone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acrosomal vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of presynaptic active zone structure IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of inhibitory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of inhibitory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
  
involved_in presynaptic dense core vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic dense core vesicle exocytosis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in presynaptic dense core vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in spontaneous neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in synaptic vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle docking IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle docking IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle priming IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of presynaptic active zone membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in inhibitory synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone cytoplasmic component IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone cytoplasmic component IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynaptic active zone cytoplasmic component ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
regulating synaptic membrane exocytosis protein 1
Names
Rab3 effector
Rab3 interacting protein 1
rab3-interacting molecule 1
regulating synaptic membrane exocytosis 1 beta
synaptic exocytosis regulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012623.4 → NP_001012641.2  regulating synaptic membrane exocytosis protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117188, AC125522, AC130211, AC147129, AC174648, AEKQ02040097, AEKQ02040098
    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1383 → 1528
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:755 → 881
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:617 → 702
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  2. NM_001012624.4 → NP_001012642.2  regulating synaptic membrane exocytosis protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117188, AC125522, AC130211, AC147129, AC174648, AEKQ02040097, AEKQ02040098
    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1359 → 1504
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:755 → 881
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:617 → 702
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  3. NM_001012625.4 → NP_001012643.2  regulating synaptic membrane exocytosis protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC117188, AC125522, AC130211, AC147129, AC174648, AEKQ02040097, AEKQ02040098
    UniProtKB/TrEMBL
    F6TZK4, F6VBV0
    Related
    ENSMUSP00000080259.8, ENSMUST00000081544.14
    Conserved Domains (6) summary
    cd04028
    Location:1308 → 1453
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:755 → 881
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:884 → 1070
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:617 → 702
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  4. NM_053270.4 → NP_444500.2  regulating synaptic membrane exocytosis protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117188, AC125522, AC130211, AC147129, AC174648, AEKQ02040097, AEKQ02040098
    UniProtKB/TrEMBL
    E9PWP6, F6VBV0
    Related
    ENSMUSP00000095417.8, ENSMUST00000097808.9
    Conserved Domains (5) summary
    cd04028
    Location:1472 → 1617
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:755 → 881
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:617 → 702
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  5. NM_183018.5 → NP_898839.3  regulating synaptic membrane exocytosis protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117188, AC125522, AC130211, AC147129, AC174648, AEKQ02040097, AEKQ02040098
    UniProtKB/TrEMBL
    F6VBV0, F6Y0S3
    Related
    ENSMUSP00000110928.4, ENSMUST00000115273.10
    Conserved Domains (6) summary
    cd04028
    Location:1444 → 1589
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:755 → 881
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:939 → 1148
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:617 → 702
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    22356196..22845239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154438.1 → XP_036010331.1  regulating synaptic membrane exocytosis protein 1 isoform X41

    Conserved Domains (4) summary
    cd04028
    Location:736 → 881
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:403 → 612
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. XM_036154447.1 → XP_036010340.1  regulating synaptic membrane exocytosis protein 1 isoform X42

    Conserved Domains (4) summary
    cd04028
    Location:703 → 848
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:403 → 604
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  3. XM_036154452.1 → XP_036010345.1  regulating synaptic membrane exocytosis protein 1 isoform X43

    UniProtKB/TrEMBL
    Q7TPL9
    Related
    ENSMUSP00000131808.2, ENSMUST00000164877.8
    Conserved Domains (1) summary
    cd04028
    Location:50 → 195
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

  4. XM_036154458.1 → XP_036010351.1  regulating synaptic membrane exocytosis protein 1 isoform X44

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (7) summary
    cd04028
    Location:1250 → 1395
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:705 → 831
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:880 → 1179
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:567 → 652
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:164 → 266
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:104 → 159
    FYVE_like_SF; FYVE domain like superfamily
    cl22851
    Location:26 → 153
    PHD_SF; PHD finger superfamily

  5. XM_036154343.1 → XP_036010236.1  regulating synaptic membrane exocytosis protein 1 isoform X28

    Conserved Domains (5) summary
    cd04028
    Location:1147 → 1292
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  6. XM_036154326.1 → XP_036010219.1  regulating synaptic membrane exocytosis protein 1 isoform X27

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1198 → 1343
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  7. XM_036154314.1 → XP_036010207.1  regulating synaptic membrane exocytosis protein 1 isoform X26

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1222 → 1367
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  8. XM_036154306.1 → XP_036010199.1  regulating synaptic membrane exocytosis protein 1 isoform X25

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (6) summary
    cd04028
    Location:1250 → 1395
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:895 → 1164
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  9. XM_036154248.1 → XP_036010141.1  regulating synaptic membrane exocytosis protein 1 isoform X21

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (6) summary
    cd04028
    Location:1311 → 1456
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:941 → 1240
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  10. XM_036153963.1 → XP_036009856.1  regulating synaptic membrane exocytosis protein 1 isoform X1

    UniProtKB/TrEMBL
    F6VBV0
    Related
    ENSMUSP00000095418.5, ENSMUST00000097809.11
    Conserved Domains (5) summary
    cd04028
    Location:1483 → 1628
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  11. XM_036154141.1 → XP_036010034.1  regulating synaptic membrane exocytosis protein 1 isoform X12

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (6) summary
    cd04028
    Location:1422 → 1567
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:705 → 831
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:567 → 652
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:164 → 266
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:104 → 159
    FYVE_like_SF; FYVE domain like superfamily
    cl22851
    Location:26 → 153
    PHD_SF; PHD finger superfamily

  12. XM_036154130.1 → XP_036010023.1  regulating synaptic membrane exocytosis protein 1 isoform X11

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (6) summary
    cd04028
    Location:1433 → 1578
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:716 → 842
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:578 → 663
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:175 → 277
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:104 → 170
    FYVE_like_SF; FYVE domain like superfamily
    cl22851
    Location:26 → 164
    PHD_SF; PHD finger superfamily

  13. XM_036154297.1 → XP_036010190.1  regulating synaptic membrane exocytosis protein 1 isoform X24

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1291 → 1436
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:574 → 700
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:436 → 521
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:33 → 135
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:1 → 28
    FYVE_like_SF; FYVE domain like superfamily

  14. XM_036154075.1 → XP_036009968.1  regulating synaptic membrane exocytosis protein 1 isoform X8

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1456 → 1601
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:739 → 865
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:601 → 686
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:198 → 300
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:127 → 193
    FYVE_like_SF; FYVE domain like superfamily

  15. XM_036154043.1 → XP_036009936.1  regulating synaptic membrane exocytosis protein 1 isoform X6

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1459 → 1604
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:742 → 868
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:604 → 689
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:201 → 303
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:130 → 196
    FYVE_like_SF; FYVE domain like superfamily

  16. XM_036154235.1 → XP_036010128.1  regulating synaptic membrane exocytosis protein 1 isoform X19

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1336 → 1481
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:732 → 858
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:594 → 679
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:191 → 293
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:131 → 186
    FYVE_like_SF; FYVE domain like superfamily

  17. XM_036154101.1 → XP_036009994.1  regulating synaptic membrane exocytosis protein 1 isoform X10

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1449 → 1594
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:732 → 858
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:594 → 679
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:191 → 293
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:131 → 186
    FYVE_like_SF; FYVE domain like superfamily

  18. XM_036154015.1 → XP_036009908.1  regulating synaptic membrane exocytosis protein 1 isoform X4

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1460 → 1605
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:743 → 869
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:605 → 690
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:202 → 304
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:131 → 197
    FYVE_like_SF; FYVE domain like superfamily

  19. XM_036154285.1 → XP_036010178.1  regulating synaptic membrane exocytosis protein 1 isoform X24

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1291 → 1436
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:574 → 700
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:436 → 521
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:33 → 135
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:1 → 28
    FYVE_like_SF; FYVE domain like superfamily

  20. XM_036154267.1 → XP_036010160.1  regulating synaptic membrane exocytosis protein 1 isoform X23

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1295 → 1440
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  21. XM_036154055.1 → XP_036009948.1  regulating synaptic membrane exocytosis protein 1 isoform X7

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1459 → 1604
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  22. XM_036154256.1 → XP_036010149.1  regulating synaptic membrane exocytosis protein 1 isoform X22

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (6) summary
    cd04028
    Location:1310 → 1455
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:895 → 1081
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  23. XM_036154243.1 → XP_036010136.1  regulating synaptic membrane exocytosis protein 1 isoform X20

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (6) summary
    cd04028
    Location:1319 → 1464
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:895 → 1081
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  24. XM_036153980.1 → XP_036009873.1  regulating synaptic membrane exocytosis protein 1 isoform X3

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (6) summary
    cd04028
    Location:1462 → 1607
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01642
    Location:982 → 1096
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  25. XM_036154227.1 → XP_036010120.1  regulating synaptic membrane exocytosis protein 1 isoform X18

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1361 → 1506
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  26. XM_036154205.1 → XP_036010098.1  regulating synaptic membrane exocytosis protein 1 isoform X17

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1370 → 1515
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  27. XM_036154195.1 → XP_036010088.1  regulating synaptic membrane exocytosis protein 1 isoform X16

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1385 → 1530
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  28. XM_036154178.1 → XP_036010071.1  regulating synaptic membrane exocytosis protein 1 isoform X15

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1394 → 1539
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  29. XM_036154086.1 → XP_036009979.1  regulating synaptic membrane exocytosis protein 1 isoform X9

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (6) summary
    cd04028
    Location:1455 → 1600
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:950 → 1159
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  30. XM_036154160.1 → XP_036010053.1  regulating synaptic membrane exocytosis protein 1 isoform X14

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (6) summary
    cd04028
    Location:1398 → 1543
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:950 → 1139
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  31. XM_036154026.1 → XP_036009919.1  regulating synaptic membrane exocytosis protein 1 isoform X5

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (6) summary
    cd04028
    Location:1459 → 1604
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:950 → 1163
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  32. XM_036154151.1 → XP_036010044.1  regulating synaptic membrane exocytosis protein 1 isoform X13

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (6) summary
    cd04028
    Location:1422 → 1567
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:977 → 1184
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  33. XM_036153973.1 → XP_036009866.1  regulating synaptic membrane exocytosis protein 1 isoform X2

    UniProtKB/TrEMBL
    F6VBV0
    Conserved Domains (5) summary
    cd04028
    Location:1474 → 1619
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:766 → 892
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:628 → 713
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:225 → 327
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 220
    FYVE_like_SF; FYVE domain like superfamily

  34. XM_036154361.1 → XP_036010254.1  regulating synaptic membrane exocytosis protein 1 isoform X29

    Conserved Domains (4) summary
    cd04028
    Location:936 → 1081
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:403 → 589
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  35. XM_036154371.1 → XP_036010264.1  regulating synaptic membrane exocytosis protein 1 isoform X30

    Conserved Domains (4) summary
    cd04028
    Location:908 → 1053
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:403 → 612
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  36. XM_036154396.1 → XP_036010289.1  regulating synaptic membrane exocytosis protein 1 isoform X32

    Conserved Domains (4) summary
    cd04028
    Location:866 → 1011
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:430 → 637
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  37. XM_036154410.1 → XP_036010303.1  regulating synaptic membrane exocytosis protein 1 isoform X35

    Conserved Domains (4) summary
    cd04028
    Location:830 → 975
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:348 → 572
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  38. XM_036154384.1 → XP_036010277.1  regulating synaptic membrane exocytosis protein 1 isoform X31

    Conserved Domains (4) summary
    cd04028
    Location:875 → 1020
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:348 → 617
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  39. XM_036154411.1 → XP_036010304.1  regulating synaptic membrane exocytosis protein 1 isoform X36

    Conserved Domains (4) summary
    cd04028
    Location:826 → 971
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01642
    Location:435 → 541
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

  40. XM_036154408.1 → XP_036010301.1  regulating synaptic membrane exocytosis protein 1 isoform X34

    Conserved Domains (4) summary
    cd04028
    Location:847 → 992
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:403 → 588
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  41. XM_036154426.1 → XP_036010319.1  regulating synaptic membrane exocytosis protein 1 isoform X38

    Conserved Domains (3) summary
    cd04028
    Location:814 → 959
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  42. XM_036154414.1 → XP_036010307.1  regulating synaptic membrane exocytosis protein 1 isoform X37

    Conserved Domains (3) summary
    cd04028
    Location:823 → 968
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  43. XM_036154433.1 → XP_036010326.1  regulating synaptic membrane exocytosis protein 1 isoform X40

    Conserved Domains (4) summary
    cd04028
    Location:763 → 908
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:348 → 560
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  44. XM_036154432.1 → XP_036010325.1  regulating synaptic membrane exocytosis protein 1 isoform X39

    UniProtKB/TrEMBL
    Q3UYL2
    Conserved Domains (4) summary
    cd04028
    Location:772 → 917
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:219 → 345
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:348 → 560
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:81 → 166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  45. XM_036154403.1 → XP_036010296.1  regulating synaptic membrane exocytosis protein 1 isoform X33

    Conserved Domains (4) summary
    cd04028
    Location:852 → 997
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:135 → 261
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:319 → 505
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:1 → 82
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99NE5.2 GenPept UniProtKB/Swiss-Prot:Q99NE5

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