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Inpp4b inositol polyphosphate-4-phosphatase type II B [ Rattus norvegicus (Norway rat) ]

Gene ID: 116699, updated on 2-Nov-2024

Summary

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Official Symbol
Inpp4bprovided by RGD
Official Full Name
inositol polyphosphate-4-phosphatase type II Bprovided by RGD
Primary source
RGD:620470
See related
EnsemblRapid:ENSRNOG00000018382 AllianceGenome:RGD:620470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Acts upstream of or within phosphatidylinositol dephosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 201.6), Thymus (RPKM 167.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Inpp4b in Genome Data Viewer
Location:
19q11
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (42824710..43575039, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (25920189..26670085, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (29592889..30341528, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene interleukin 15 Neighboring gene uncharacterized LOC134483507 Neighboring gene uncharacterized LOC134483338 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 6 Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein S15, pseudogene 8 Neighboring gene ribosomal protein L35, pseudogene 11 Neighboring gene ubiquitin specific peptidase 38

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. Norris FA, et al. J Biol Chem, 1997 Sep 19. PMID 9295334
  2. Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomas. Balakrishnan A, et al. Dev Biol, 2013 Jan 1. PMID 23078915, Free PMC Article
  3. Characterization of the murine Inpp4b gene and identification of a novel isoform. Ferron M, et al. Gene, 2006 Jul 5. PMID 16631325
  4. Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans. Ferron M, et al. Cell Metab, 2011 Oct 5. PMID 21982707, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables inositol-1,3,4-trisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-3,4-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol bisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol trisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of bone remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
type II inositol 3,4-bisphosphate 4-phosphatase
Names
inositol polyphosphate 4-phosphatase type II
inositol polyphosphate-4-phosphatase, type II, 105kD
NP_446369.1
XP_008770684.1
XP_017456652.1
XP_017456654.1
XP_038953356.1
XP_038953357.1
XP_038953358.1
XP_038953362.1
XP_038953363.1
XP_063133804.1
XP_063133806.1
XP_063133807.1
XP_063133808.1
XP_063133809.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431397.1 → NP_001418326.1  type II inositol 3,4-bisphosphate 4-phosphatase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IYG6

  2. NM_053917.2 → NP_446369.1  type II inositol 3,4-bisphosphate 4-phosphatase

    See identical proteins and their annotated locations for NP_446369.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IYG6
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    42824710..43575039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277738.1 → XP_063133808.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X5

  2. XM_063277736.1 → XP_063133806.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X3

    UniProtKB/Swiss-Prot
    O35825, Q9QWG5
    UniProtKB/TrEMBL
    A6IYG5
    Related
    ENSRNOP00000024981.4, ENSRNOT00000024981.8

  3. XM_017601165.3 → XP_017456654.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

    UniProtKB/TrEMBL
    A0A8I6A1I3
    Conserved Domains (1) summary
    cd04048
    Location:39 → 158
    C2A_Copine; C2 domain first repeat in Copine

  4. XM_039097430.2 → XP_038953358.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X2

    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  5. XM_017601163.3 → XP_017456652.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  6. XM_063277734.1 → XP_063133804.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    UniProtKB/TrEMBL
    A6IYG6

  7. XM_039097428.2 → XP_038953356.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    UniProtKB/TrEMBL
    A6IYG6
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  8. XM_063277739.1 → XP_063133809.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X6

  9. XM_039097429.2 → XP_038953357.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    UniProtKB/TrEMBL
    A6IYG6
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  10. XM_063277737.1 → XP_063133807.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

    UniProtKB/TrEMBL
    A0A8I6A1I3
    Related
    ENSRNOP00000085379.1, ENSRNOT00000097624.2

  11. XM_008772462.4 → XP_008770684.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_008770684.1

    UniProtKB/TrEMBL
    A6IYG6
    Related
    ENSRNOP00000025013.4, ENSRNOT00000025013.6
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  12. XM_039097435.2 → XP_038953363.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X7

  13. XM_039097434.2 → XP_038953362.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X7

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QWG5.1 GenPept UniProtKB/Swiss-Prot:Q9QWG5

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