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Ly6g6d lymphocyte antigen 6 family member G6D [ Mus musculus (house mouse) ]

Gene ID: 114654, updated on 18-Sep-2024

Summary

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Official Symbol
Ly6g6dprovided by MGI
Official Full Name
lymphocyte antigen 6 family member G6Dprovided by MGI
Primary source
MGI:MGI:2148931
See related
Ensembl:ENSMUSG00000073413 AllianceGenome:MGI:2148931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G6d; G6f; NG25; NG32; MEGT1; g6f-ly6g6d; A930024F17Rik
Summary
Enables acetylcholine receptor inhibitor activity and identical protein binding activity. Acts upstream of or within acetylcholine receptor signaling pathway. Part of protein-containing complex. Colocalizes with external side of plasma membrane. Is expressed in brain; embryo; lung; and metanephros. Orthologous to human LY6G6D (lymphocyte antigen 6 family member G6D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 4.5), lung adult (RPKM 3.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Ly6g6d in Genome Data Viewer
Location:
17 B1; 17 18.59 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35290318..35300215, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35071342..35081239, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene megakaryocyte and platelet inhibitory receptor G6b Neighboring gene G6b opposite strand Neighboring gene lymphocyte antigen 6 family member G6C Neighboring gene STARR-seq mESC enhancer starr_42446 Neighboring gene lymphocyte antigen 6 family member G6E Neighboring gene lymphocyte antigen 6 family member G6F Neighboring gene STARR-positive B cell enhancer ABC_E7527 Neighboring gene abhydrolase domain containing 16A Neighboring gene lymphocyte antigen 6 family member G5C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. Mallya M, et al. Genomics, 2002 Jul. PMID 12079290
  2. Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family. Wu M, et al. J Biol Chem, 2015 Oct 2. PMID 26276394, Free PMC Article
  3. Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands. Mallya M, et al. Protein Sci, 2006 Oct. PMID 17008713, Free PMC Article
  4. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
  5. The mouse as a model for the effects of MHC genes on human disease. Allcock RJ, et al. Immunol Today, 2000 Jul. PMID 10871872

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lymphocyte antigen 6 complex locus protein G6d
Names
lymphocyte antigen 6 complex, locus G6D
megakaryocyte-enhanced gene transcript 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371027.1 → NP_001357956.1  lymphocyte antigen 6 complex locus protein G6d isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087117
    UniProtKB/TrEMBL
    A0A1L6ZA43

  2. NM_001371028.1 → NP_001357957.1  lymphocyte antigen 6 complex locus protein G6d isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087117
    UniProtKB/TrEMBL
    A0A1L6ZA36

  3. NM_033478.3 → NP_258439.1  lymphocyte antigen 6 complex locus protein G6d isoform 1 precursor

    See identical proteins and their annotated locations for NP_258439.1

    Status: VALIDATED

    Source sequence(s)
    AC087117
    Consensus CDS
    CCDS28678.1
    UniProtKB/Swiss-Prot
    Q9Z1Q3
    UniProtKB/TrEMBL
    A0A1L6ZA36
    Related
    ENSMUSP00000007259.4, ENSMUST00000007259.4

RNA

  1. NR_163839.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087117

  2. NR_163840.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087117

  3. NR_163841.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087117

  4. NR_163842.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087117
    Related
    ENSMUST00000172639.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35290318..35300215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003726.1: Suppressed sequence

    Description
    NM_001003726.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

  2. NM_176969.3: Suppressed sequence

    Description
    NM_176969.3: This RefSeq was permanently suppressed because insufficient support exists for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1Q3.1 GenPept UniProtKB/Swiss-Prot:Q9Z1Q3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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