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PRR4 proline rich 4 [ Homo sapiens (human) ]

Gene ID: 11272, updated on 2-Nov-2024

Summary

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Official Symbol
PRR4provided by HGNC
Official Full Name
proline rich 4provided by HGNC
Primary source
HGNC:HGNC:18020
See related
Ensembl:ENSG00000111215 MIM:605359; AllianceGenome:HGNC:18020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPRP; PROL4
Summary
This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]
Expression
Restricted expression toward salivary gland (RPKM 1815.0) See more
Orthologs
all
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Genomic context

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See PRR4 in Genome Data Viewer
Location:
12p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10845849..10849475, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10718942..10722568, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10998448..11002074, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene taste 2 receptor member 7 pseudogene Neighboring gene taste 2 receptor member 10 Neighboring gene PRH1-PRR4 readthrough Neighboring gene Sharpr-MPRA regulatory region 13514 Neighboring gene taste 2 receptor member 12 pseudogene Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene taste 2 receptor member 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of lacrimal proline-rich protein 4 (PRR4) in human tear proteome. Perumal N, et al. Proteomics, 2014 Jul. PMID 24782455
  2. A major human lacrimal gland mRNA encodes a new proline-rich protein family member. Dickinson DP, et al. Invest Ophthalmol Vis Sci, 1995 Sep. PMID 7544782
  3. Characterization of the in vivo forms of lacrimal-specific proline-rich proteins in human tear fluid. Fung KY, et al. Proteomics, 2004 Dec. PMID 15526346
  4. Characterization of human reflex tear proteome reveals high expression of lacrimal proline-rich protein 4 (PRR4). Perumal N, et al. Proteomics, 2015 Oct. PMID 26173177
  5. Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome. Aluru SV, et al. PLoS One, 2012. PMID 23272196, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High expression of lacrimal proline-rich protein 4 (PRR4) was found in reflex tears.
    Title: Characterization of human reflex tear proteome reveals high expression of lacrimal proline-rich protein 4 (PRR4).
  2. A new PRR4 isoform designated as PRR4-N3 in addition to PRR4 (gi154448886) and pHL E1F1 (gi1050983) was identified in human tear proteome.
    Title: Characterization of lacrimal proline-rich protein 4 (PRR4) in human tear proteome.
  3. Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
    Title: Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough PRH1-PRR4

Readthrough gene: PRH1-PRR4, Included gene: PRH1

Homology

Clone Names

  • FLJ18757, DKFZp779L1763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in visual perception TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 

General protein information

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Preferred Names
proline-rich protein 4
Names
lacrimal proline-rich protein
nasopharyngeal carcinoma-associated proline-rich protein 4
proline rich 4 (lacrimal)
proline-rich polypeptide 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098538.3 → NP_001092008.2  proline-rich protein 4 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 2. The resulting isoform (1) has a distinct and shorter C-terminus, compared to isoform 2.
    Source sequence(s)
    AF530472, AK292934, BX537839
    Consensus CDS
    CCDS55804.1
    UniProtKB/Swiss-Prot
    Q16378
    Related
    ENSP00000438046.1, ENST00000544994.5

  2. NM_007244.3 → NP_009175.2  proline-rich protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_009175.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AF530472, DB229285
    Consensus CDS
    CCDS41756.1
    UniProtKB/Swiss-Prot
    A8KA69, F5H0D7, Q16378, Q8NFB3
    Related
    ENSP00000228811.4, ENST00000228811.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    10845849..10849475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    44555..48181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    44555..48181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    10718942..10722568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16378.3 GenPept UniProtKB/Swiss-Prot:Q16378

Gene LinkOut

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