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NRM nurim [ Homo sapiens (human) ]

Gene ID: 11270, updated on 14-Nov-2024

Summary

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Official Symbol
NRMprovided by HGNC
Official Full Name
nurimprovided by HGNC
Primary source
HGNC:HGNC:8003
See related
Ensembl:ENSG00000137404 MIM:620017; AllianceGenome:HGNC:8003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRM29
Summary
The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in skin (RPKM 5.3), bone marrow (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

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See NRM in Genome Data Viewer
Location:
6p21.33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30688049..30691420, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30552255..30555626, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30655826..30659197, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene prothymosin alpha pseudogene 1 Neighboring gene chromosome 6 open reading frame 136 Neighboring gene DEAH-box helicase 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30638704-30639302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30640498-30641094 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:30642736-30642875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30649761-30650650 Neighboring gene protein phosphatase 1 regulatory subunit 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30650651-30651540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30668297-30668798 Neighboring gene ribosomal protein L7 pseudogene 4 Neighboring gene MDC1 antisense RNA 1 Neighboring gene mediator of DNA damage checkpoint 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inner nuclear membrane proteins: functions and targeting. Holmer L, et al. Cell Mol Life Sci, 2001 Nov. PMID 11766875, Free PMC Article
  2. Analysis of the localization and topology of nurim, a polytopic protein tightly associated with the inner nuclear membrane. Hofemeister H, et al. J Biol Chem, 2005 Jan 28. PMID 15542857
  3. Early sorting of inner nuclear membrane proteins is conserved. Braunagel SC, et al. Proc Natl Acad Sci U S A, 2007 May 29. PMID 17517639, Free PMC Article
  4. The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis. Chen H, et al. Curr Mol Med, 2012 Dec. PMID 23092226
  5. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. Rolls MM, et al. J Cell Biol, 1999 Jul 12. PMID 10402458, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings implicate that the inner nuclear membrane protein Nurim plays an important role in the suppression of apoptosis
    Title: The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis.
  2. nurim is a polytopic protein tightly associated with the inner nuclear membrane
    Title: Analysis of the localization and topology of nurim, a polytopic protein tightly associated with the inner nuclear membrane.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane HDA PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
nurim
Names
nuclear rim protein
nurim (nuclear envelope membrane protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270707.2 → NP_001257636.1  nurim isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform 2 which is longer than isoform 1.
    Source sequence(s)
    AK075509, BC039865, BU159435
    UniProtKB/TrEMBL
    B3KQU6

  2. NM_001270708.2 → NP_001257637.1  nurim isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. It terminates translation at an alternate stop codon resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AI521967, BC039865, BM917173
    UniProtKB/Swiss-Prot
    Q8IXM6
    UniProtKB/TrEMBL
    B3KQU6
    Related
    ENST00000462857.5

  3. NM_001270709.2 → NP_001257638.1  nurim isoform 4

    See identical proteins and their annotated locations for NP_001257638.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.
    Source sequence(s)
    JQ798186
    Consensus CDS
    CCDS59498.1
    UniProtKB/Swiss-Prot
    Q8IXM6
    UniProtKB/TrEMBL
    B3KQU6
    Related
    ENSP00000365602.5, ENST00000376420.9

  4. NM_001270710.2 → NP_001257639.1  nurim isoform 5

    See identical proteins and their annotated locations for NP_001257639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region compared to variant 1. The resulting isoform (5) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    JQ798187
    UniProtKB/Swiss-Prot
    Q8IXM6
    UniProtKB/TrEMBL
    B3KQU6
    Related
    ENST00000474864.5

  5. NM_001384369.1 → NP_001371298.1  nurim isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL662797
    Consensus CDS
    CCDS4686.1
    UniProtKB/Swiss-Prot
    B0S7R0, B0S7R1, I3XIE2, I3XIE3, Q5JP57, Q5JP58, Q5JP59, Q5JP60, Q8IXM6, Q8WU45, Q9BSX3, Q9UN92
    UniProtKB/TrEMBL
    A0A1U9X845, B3KQU6
    Related
    ENSP00000365603.5, ENST00000376421.7

  6. NM_007243.3 → NP_009174.1  nurim isoform 1

    See identical proteins and their annotated locations for NP_009174.1

    Status: REVIEWED

    Source sequence(s)
    AL662797
    Consensus CDS
    CCDS4686.1
    UniProtKB/Swiss-Prot
    B0S7R0, B0S7R1, I3XIE2, I3XIE3, Q5JP57, Q5JP58, Q5JP59, Q5JP60, Q8IXM6, Q8WU45, Q9BSX3, Q9UN92
    UniProtKB/TrEMBL
    A0A1U9X845, B3KQU6
    Related
    ENSP00000259953.4, ENST00000259953.8

RNA

  1. NR_073065.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI521967, BC039865, BM847576
    Related
    ENST00000470733.1

  2. NR_073066.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI521967, AK075509, AK298152
    Related
    ENST00000482141.5

  3. NR_073072.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL662797
    Related
    ENST00000444096.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30688049..30691420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418138.1 → XP_047274094.1  nurim isoform X2

  2. XM_017010224.3 → XP_016865713.1  nurim isoform X1

    UniProtKB/TrEMBL
    B4DP16

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2017556..2020927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328446.1 → XP_054184421.1  nurim isoform X2

  2. XM_054328445.1 → XP_054184420.1  nurim isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    2167793..2171164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329730.1 → XP_054185705.1  nurim isoform X2

  2. XM_054329729.1 → XP_054185704.1  nurim isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    1943903..1947274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330228.1 → XP_054186203.1  nurim isoform X2

  2. XM_054330227.1 → XP_054186202.1  nurim isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    1998302..2001673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330516.1 → XP_054186491.1  nurim isoform X2

  2. XM_054330515.1 → XP_054186490.1  nurim isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    2032126..2035497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330763.1 → XP_054186738.1  nurim isoform X2

  2. XM_054330762.1 → XP_054186737.1  nurim isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    1943163..1946534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331000.1 → XP_054186975.1  nurim isoform X2

  2. XM_054330999.1 → XP_054186974.1  nurim isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    30552255..30555626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354141.1 → XP_054210116.1  nurim isoform X2

  2. XM_054354140.1 → XP_054210115.1  nurim isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IXM6.1 GenPept UniProtKB/Swiss-Prot:Q8IXM6

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