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SP140 SP140 nuclear body protein [ Homo sapiens (human) ]

Gene ID: 11262, updated on 2-Nov-2024

Summary

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Official Symbol
SP140provided by HGNC
Official Full Name
SP140 nuclear body proteinprovided by HGNC
Primary source
HGNC:HGNC:17133
See related
Ensembl:ENSG00000079263 MIM:608602; AllianceGenome:HGNC:17133
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYSP100; LYSP100-A; LYSP100-B
Summary
This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
Expression
Biased expression in lymph node (RPKM 12.2), spleen (RPKM 7.6) and 10 other tissues See more
Orthologs
all
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Genomic context

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See SP140 in Genome Data Viewer
Location:
2q37.1
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (230186151..230316571)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (230669263..230808985)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231090451..231177930)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 14 Neighboring gene uncharacterized LOC107985995 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230932348-230933118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17208 Neighboring gene RNY4 pseudogene 19 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:231005392-231005920 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12407 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:231044589-231045131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17209 Neighboring gene SP110 nuclear body protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17210 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:231084625-231084811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231129497-231130018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12408 Neighboring gene MPRA-validated peak4075 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:231176974-231178173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231206345-231206936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17219 Neighboring gene SP140 nuclear body protein like Neighboring gene uncharacterized LOC105373925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17223 Neighboring gene uncharacterized LOC101928816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17224 Neighboring gene SP100 nuclear antigen Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17225 Neighboring gene RNA, 7SL, cytoplasmic 834, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response. Tanagala KKK, et al. J Immunother Cancer, 2022 Dec. PMID 36600652, Free PMC Article
  2. Identification and characterization of a leukocyte-specific component of the nuclear body. Bloch DB, et al. J Biol Chem, 1996 Nov 15. PMID 8910577
  3. PML nuclear body component Sp140 is a novel autoantigen in primary biliary cirrhosis. Granito A, et al. Am J Gastroenterol, 2010 Jan. PMID 19861957
  4. Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain. Zucchelli C, et al. Biochim Biophys Acta Gen Subj, 2019 Feb. PMID 30465816
  5. SP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κB inhibition. Karaky M, et al. Hum Mol Genet, 2018 Dec 1. PMID 30102396

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptional regulators SP110 and SP140 modulate inflammatory response genes in Mycobacterium tuberculosis-infected human macrophages.
    Title: Transcriptional regulators SP110 and SP140 modulate inflammatory response genes in Mycobacterium tuberculosis-infected human macrophages.
  2. SP140 inhibits STAT1 signaling, induces IFN-gamma in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response.
    Title: SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response.
  3. Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.
    Title: Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.
  4. Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.
    Title: Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.
  5. The Sp140 is multi-SUMOylated and its PHD finger works as versatile protein-protein interaction platform promoting intramolecular SUMOylation of the adjacent BRD.
    Title: Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain.
  6. Our findings showed that SP140 is an important repressor of genes implicated in inflammation, suggesting that decreased expression of SP140, promoted by the rs28445040-T risk variant, may lead to up-regulation of these genes by means of NF-kappaB inhibition in B cells.
    Title: SP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κB inhibition.
  7. IL1R2 hypomethylation and androgen receptor hypermethylation may constitute an important determinant of disease severity, whereas NPR2 hypomethylation and SP140 hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea
    Title: Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype.
  8. Data identified rs28445040 variant in SP140 gene as the causal factor for skipping of exon 7 and the most associated with multiple sclerosis.
    Title: A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.
  10. the nuclear body protein Sp140, was found specifically in all NP cells (n = 12 cell lines tested; P < or = 0.001), and HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif
    Title: Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
EBI GWAS Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif Wild-type HIV-1 Vif binds to the carboxyl-terminal region of Sp140 between amino acids 527-836, while Vif mutants with deletions of amino acids 12-23, 43-59, 73-87 or 97-112 are strongly inhibited in their binding to Sp140 PubMed
vif HIV-1 Vif may enhance the cytosolic retention of Sp140 PubMed
vif Specific binding of HIV-1 Vif to Sp140 was identified using a yeast two-hybrid screen of a human lymphocyte cDNA library and verified by co-immunoprecipitation PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126440

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear body protein SP140
Names
lymphoid-restricted homolog of Sp100
lymphoid-specific SP100 homolog
nuclear autoantigen Sp-140
speckled 140 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051286.2 RefSeqGene

    Range
    44587..132066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005176.3 → NP_001005176.1  nuclear body protein SP140 isoform 2

    See identical proteins and their annotated locations for NP_001005176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons, and has an alternate 3' sequence, as compared to variant 1. The encoded isoform 2 is much shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AA741304, AK301267, BC070160
    Consensus CDS
    CCDS33392.1
    UniProtKB/Swiss-Prot
    Q13342
    UniProtKB/TrEMBL
    B4DVW8
    Related
    ENSP00000362749.3, ENST00000373645.3
    Conserved Domains (1) summary
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  2. NM_001278451.2 → NP_001265380.1  nuclear body protein SP140 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC009949, BC105960, DC391925, U36499
    Consensus CDS
    CCDS63150.1
    UniProtKB/TrEMBL
    Q0VGE4
    Related
    ENSP00000398210.3, ENST00000420434.7
    Conserved Domains (4) summary
    cd05501
    Location:730 → 833
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:665 → 706
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:558 → 633
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  3. NM_001278452.2 → NP_001265381.1  nuclear body protein SP140 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC009949, BC105744, DC391925, U36499
    Consensus CDS
    CCDS63151.1
    UniProtKB/TrEMBL
    Q0VGE4
    Related
    ENSP00000342096.6, ENST00000343805.10
    Conserved Domains (5) summary
    cd05501
    Location:697 → 800
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    PHA03169
    Location:202 → 419
    PHA03169; hypothetical protein; Provisional
    cd15626
    Location:632 → 673
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:525 → 600
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  4. NM_001278453.2 → NP_001265382.1  nuclear body protein SP140 isoform 5

    See identical proteins and their annotated locations for NP_001265382.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate in-frame exons and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC009949, AC009950, DC391925, U36499, U63420
    Consensus CDS
    CCDS63149.1
    UniProtKB/TrEMBL
    Q0VGE4
    Related
    ENSP00000393618.3, ENST00000417495.7
    Conserved Domains (4) summary
    cd05501
    Location:643 → 746
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:578 → 619
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:471 → 546
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  5. NM_007237.5 → NP_009168.4  nuclear body protein SP140 isoform 1

    See identical proteins and their annotated locations for NP_009168.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009949, AK301267, BC038091, BC105960, U36500
    Consensus CDS
    CCDS42831.1
    UniProtKB/Swiss-Prot
    E7ESH9, E7EUR5, E9PFJ6, Q0VGE5, Q13341, Q13342, Q3KR17, Q4ZG66, Q53TG1, Q6NSG4, Q92881, Q96TG3
    UniProtKB/TrEMBL
    Q0VGE4
    Related
    ENSP00000375899.3, ENST00000392045.8
    Conserved Domains (4) summary
    cd05501
    Location:757 → 860
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:692 → 733
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:585 → 660
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    230186151..230316571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443073.1 → XP_047299029.1  nuclear body protein SP140 isoform X7

  2. XM_011510517.4 → XP_011508819.1  nuclear body protein SP140 isoform X7

    See identical proteins and their annotated locations for XP_011508819.1

    UniProtKB/TrEMBL
    Q0VGE4
    Conserved Domains (4) summary
    cd05501
    Location:737 → 840
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:672 → 713
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:565 → 640
    SAND; SAND domain
    pfam03172
    Location:22 → 115
    Sp100; Sp100 domain

  3. XM_006712223.4 → XP_006712286.1  nuclear body protein SP140 isoform X1

    UniProtKB/TrEMBL
    B4DVW8
    Conserved Domains (4) summary
    cd15626
    Location:692 → 733
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:585 → 660
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain
    cl02556
    Location:757 → 838
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  4. XM_047443077.1 → XP_047299033.1  nuclear body protein SP140 isoform X21

  5. XM_011510518.3 → XP_011508820.1  nuclear body protein SP140 isoform X7

    See identical proteins and their annotated locations for XP_011508820.1

    UniProtKB/TrEMBL
    Q0VGE4
    Conserved Domains (4) summary
    cd05501
    Location:737 → 840
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:672 → 713
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:565 → 640
    SAND; SAND domain
    pfam03172
    Location:22 → 115
    Sp100; Sp100 domain

  6. XM_011510516.2 → XP_011508818.1  nuclear body protein SP140 isoform X5

    UniProtKB/TrEMBL
    Q0VGE4
    Conserved Domains (4) summary
    cd05501
    Location:748 → 851
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:692 → 726
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:585 → 660
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  7. XM_011510515.2 → XP_011508817.1  nuclear body protein SP140 isoform X3

    UniProtKB/TrEMBL
    Q0VGE4
    Conserved Domains (4) summary
    cd05501
    Location:751 → 854
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:686 → 727
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:579 → 654
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  8. XM_005246254.3 → XP_005246311.1  nuclear body protein SP140 isoform X13

    UniProtKB/TrEMBL
    Q0VGE4
    Conserved Domains (4) summary
    cd05501
    Location:723 → 826
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:658 → 699
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:551 → 626
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  9. XM_011510519.2 → XP_011508821.1  nuclear body protein SP140 isoform X9

    UniProtKB/TrEMBL
    Q0VGE4
    Conserved Domains (4) summary
    cd05501
    Location:730 → 833
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:665 → 706
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:558 → 633
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  10. XM_005246256.3 → XP_005246313.1  nuclear body protein SP140 isoform X20

    UniProtKB/TrEMBL
    Q0VGE4
    Conserved Domains (4) summary
    cd05501
    Location:696 → 799
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:631 → 672
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:524 → 599
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  11. XM_047443078.1 → XP_047299034.1  nuclear body protein SP140 isoform X24

  12. XM_005246255.3 → XP_005246312.1  nuclear body protein SP140 isoform X16

    UniProtKB/TrEMBL
    B4DVW8
    Conserved Domains (4) summary
    cd05501
    Location:707 → 810
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:642 → 683
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:535 → 610
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  13. XM_047443076.1 → XP_047299032.1  nuclear body protein SP140 isoform X19

  14. XM_017003252.2 → XP_016858741.1  nuclear body protein SP140 isoform X28

    UniProtKB/TrEMBL
    Q0VGE4

  15. XM_005246253.3 → XP_005246310.1  nuclear body protein SP140 isoform X8

    UniProtKB/TrEMBL
    Q0VGE4
    Conserved Domains (5) summary
    cd05501
    Location:731 → 834
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    PHA03169
    Location:202 → 453
    PHA03169; hypothetical protein; Provisional
    cd15626
    Location:666 → 707
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:559 → 634
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  16. XM_017003240.2 → XP_016858729.1  nuclear body protein SP140 isoform X12

    UniProtKB/TrEMBL
    Q0VGE4

  17. XM_017003249.2 → XP_016858738.1  nuclear body protein SP140 isoform X26

    UniProtKB/TrEMBL
    Q0VGE4

  18. XM_005246252.3 → XP_005246309.1  nuclear body protein SP140 isoform X2

    UniProtKB/TrEMBL
    Q0VGE4
    Conserved Domains (4) summary
    cd05501
    Location:754 → 857
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:689 → 730
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:582 → 657
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  19. XM_047443072.1 → XP_047299028.1  nuclear body protein SP140 isoform X6

  20. XM_017003239.2 → XP_016858728.1  nuclear body protein SP140 isoform X4

    UniProtKB/TrEMBL
    Q0VGE4

  21. XM_017003243.2 → XP_016858732.1  nuclear body protein SP140 isoform X15

    UniProtKB/TrEMBL
    Q0VGE4

  22. XM_047443074.1 → XP_047299030.1  nuclear body protein SP140 isoform X11

  23. XM_017003248.2 → XP_016858737.1  nuclear body protein SP140 isoform X23

    UniProtKB/TrEMBL
    Q0VGE4

  24. XM_047443079.1 → XP_047299035.1  nuclear body protein SP140 isoform X25

  25. XM_017003245.2 → XP_016858734.1  nuclear body protein SP140 isoform X17

    UniProtKB/TrEMBL
    B4DVW8

  26. XM_011510520.2 → XP_011508822.1  nuclear body protein SP140 isoform X10

    UniProtKB/TrEMBL
    Q0VGE4
    Conserved Domains (4) summary
    cd05501
    Location:728 → 831
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:663 → 704
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:556 → 631
    SAND; SAND domain
    pfam03172
    Location:42 → 135
    Sp100; Sp100 domain

  27. XM_017003242.2 → XP_016858731.1  nuclear body protein SP140 isoform X14

    UniProtKB/TrEMBL
    Q0VGE4

  28. XM_017003247.2 → XP_016858736.1  nuclear body protein SP140 isoform X22

    UniProtKB/TrEMBL
    Q0VGE4

  29. XM_017003246.2 → XP_016858735.1  nuclear body protein SP140 isoform X18

    UniProtKB/TrEMBL
    Q0VGE4

  30. XM_017003250.2 → XP_016858739.1  nuclear body protein SP140 isoform X27

    UniProtKB/TrEMBL
    Q0VGE4

  31. XM_047443080.1 → XP_047299036.1  nuclear body protein SP140 isoform X29

  32. XM_047443081.1 → XP_047299037.1  nuclear body protein SP140 isoform X31

  33. XM_017003253.2 → XP_016858742.1  nuclear body protein SP140 isoform X30

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    230669263..230808985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340304.1 → XP_054196279.1  nuclear body protein SP140 isoform X7

  2. XM_054340302.1 → XP_054196277.1  nuclear body protein SP140 isoform X7

  3. XM_054340296.1 → XP_054196271.1  nuclear body protein SP140 isoform X1

  4. XM_054340318.1 → XP_054196293.1  nuclear body protein SP140 isoform X21

  5. XM_054340303.1 → XP_054196278.1  nuclear body protein SP140 isoform X7

  6. XM_054340300.1 → XP_054196275.1  nuclear body protein SP140 isoform X5

  7. XM_054340298.1 → XP_054196273.1  nuclear body protein SP140 isoform X3

  8. XM_054340310.1 → XP_054196285.1  nuclear body protein SP140 isoform X13

  9. XM_054340306.1 → XP_054196281.1  nuclear body protein SP140 isoform X9

  10. XM_054340317.1 → XP_054196292.1  nuclear body protein SP140 isoform X20

  11. XM_054340321.1 → XP_054196296.1  nuclear body protein SP140 isoform X24

  12. XM_054340313.1 → XP_054196288.1  nuclear body protein SP140 isoform X16

  13. XM_054340316.1 → XP_054196291.1  nuclear body protein SP140 isoform X19

  14. XM_054340325.1 → XP_054196300.1  nuclear body protein SP140 isoform X28

  15. XM_054340305.1 → XP_054196280.1  nuclear body protein SP140 isoform X8

  16. XM_054340309.1 → XP_054196284.1  nuclear body protein SP140 isoform X12

  17. XM_054340323.1 → XP_054196298.1  nuclear body protein SP140 isoform X26

  18. XM_054340297.1 → XP_054196272.1  nuclear body protein SP140 isoform X2

  19. XM_054340301.1 → XP_054196276.1  nuclear body protein SP140 isoform X6

  20. XM_054340299.1 → XP_054196274.1  nuclear body protein SP140 isoform X4

  21. XM_054340312.1 → XP_054196287.1  nuclear body protein SP140 isoform X15

  22. XM_054340308.1 → XP_054196283.1  nuclear body protein SP140 isoform X11

  23. XM_054340320.1 → XP_054196295.1  nuclear body protein SP140 isoform X23

  24. XM_054340322.1 → XP_054196297.1  nuclear body protein SP140 isoform X25

  25. XM_054340314.1 → XP_054196289.1  nuclear body protein SP140 isoform X17

  26. XM_054340307.1 → XP_054196282.1  nuclear body protein SP140 isoform X10

  27. XM_054340311.1 → XP_054196286.1  nuclear body protein SP140 isoform X14

  28. XM_054340319.1 → XP_054196294.1  nuclear body protein SP140 isoform X22

  29. XM_054340315.1 → XP_054196290.1  nuclear body protein SP140 isoform X18

  30. XM_054340324.1 → XP_054196299.1  nuclear body protein SP140 isoform X27

  31. XM_054340326.1 → XP_054196301.1  nuclear body protein SP140 isoform X29

  32. XM_054340328.1 → XP_054196303.1  nuclear body protein SP140 isoform X31

  33. XM_054340327.1 → XP_054196302.1  nuclear body protein SP140 isoform X30

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13342.2 GenPept UniProtKB/Swiss-Prot:Q13342

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