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FZD10 frizzled class receptor 10 [ Homo sapiens (human) ]

Gene ID: 11211, updated on 14-Nov-2024

Summary

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Official Symbol
FZD10provided by HGNC
Official Full Name
frizzled class receptor 10provided by HGNC
Primary source
HGNC:HGNC:4039
See related
Ensembl:ENSG00000111432 MIM:606147; AllianceGenome:HGNC:4039
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fz10; FzE7; CD350; FZ-10; hFz10
Summary
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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See FZD10 in Genome Data Viewer
Location:
12q24.33
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (130162464..130165740)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (130199607..130202883)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (130647009..130650285)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903088 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25699 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25704 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25722 Neighboring gene FZD10 antisense divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:130645489-130646055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:130646056-130646622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:130648209-130649204 Neighboring gene NANOG hESC enhancer GRCh37_chr12:130649290-130649835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:130667832-130668510 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:130677479-130677979 Neighboring gene Sharpr-MPRA regulatory region 11699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:130682728-130683228 Neighboring gene ribosomal protein S20 pseudogene 30 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25789 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25816 Neighboring gene uncharacterized LOC107984480

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways. Wang J, et al. Gastroenterology, 2023 May. PMID 36764493
  2. Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB. Shin HW, et al. Korean J Hepatol, 2009 Dec. PMID 20037267
  3. Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors. Carmon KS, et al. Anal Biochem, 2010 Jun 15. PMID 20227380, Free PMC Article
  4. Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors. Nagayama S, et al. Cancer Sci, 2009 Mar. PMID 19134005, Free PMC Article
  5. N(6)-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance. Fukumoto T, et al. Cancer Res, 2019 Jun 1. PMID 30967398, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/beta-Catenin and Hippo Signaling Pathways.
    Title: N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
  2. [Exosomal FZD10 derived from non-small cell lung cancer cells promotes angiogenesis of human umbilical venous endothelial cells in vitro].
    Title: [Exosomal FZD10 derived from non-small cell lung cancer cells promotes angiogenesis of human umbilical venous endothelial cells in vitro].
  3. Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10.
    Title: Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10.
  4. SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of Wnt/beta-catenin signaling pathway via miR92b-3p/FZD10 in nasopharyngeal carcinoma cells.
    Title: SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of Wnt/β-catenin signaling pathway via miR92b-3p/FZD10 in nasopharyngeal carcinoma cells.
  5. A Possible Role of FZD10 Delivering Exosomes Derived from Colon Cancers Cell Lines in Inducing Activation of Epithelial-Mesenchymal Transition in Normal Colon Epithelial Cell Line.
    Title: A Possible Role of FZD10 Delivering Exosomes Derived from Colon Cancers Cell Lines in Inducing Activation of Epithelial-Mesenchymal Transition in Normal Colon Epithelial Cell Line.
  6. N(6)-methylation of adenosine of FZD10 mRNA contributes to PARP inhibitor resistance in the ovarian cancer cells.
    Title: N(6)-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance.
  7. The tumor associated antigen hFZD10 produced as a fusion protein with mTEM7 could be used to enrich scFv antibodies from a yeast display library.
    Title: A fusion-protein approach enabling mammalian cell production of tumor targeting protein domains for therapeutic development.
  8. the selective expression of FZD10 in brain vascular endothelial cells points at a potential role of FZD10-Galpha13 signalling in central nervous system angiogenesis.
    Title: FZD(10)-Gα(13) signalling axis points to a role of FZD(10) in CNS angiogenesis.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
  10. there was a strong inverse correlation between nuclear immunostaining scores for beta-catenin expression and expression patterns of FZD10
    Title: Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of a quantitative disordered gambling trait.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables Wnt receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
frizzled-10
Names
frizzled 10, seven transmembrane spanning receptor
frizzled family receptor 10
frizzled homolog 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007197.4 → NP_009128.1  frizzled-10 precursor

    See identical proteins and their annotated locations for NP_009128.1

    Status: REVIEWED

    Source sequence(s)
    AB027464, AC026336, AI697875, BC070037, BC074997
    Consensus CDS
    CCDS9267.1
    UniProtKB/Swiss-Prot
    Q9ULW2
    UniProtKB/TrEMBL
    Q6NSL8
    Related
    ENSP00000229030.4, ENST00000229030.5
    Conserved Domains (2) summary
    cd07462
    Location:30 → 156
    CRD_FZ10; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 10 (Fz10) receptor
    cd15037
    Location:217 → 535
    7tmF_FZD10; class F frizzled subfamily 10, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    130162464..130165740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    130199607..130202883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULW2.1 GenPept UniProtKB/Swiss-Prot:Q9ULW2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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