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CHEK2 checkpoint kinase 2 [ Homo sapiens (human) ]

Gene ID: 11200, updated on 14-Nov-2024

Summary

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Official Symbol
CHEK2provided by HGNC
Official Full Name
checkpoint kinase 2provided by HGNC
Primary source
HGNC:HGNC:16627
See related
Ensembl:ENSG00000183765 MIM:604373; AllianceGenome:HGNC:16627
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDS1; CHK2; LFS2; RAD53; TPDS4; hCds1; HuCds1; PP1425
Summary
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Ubiquitous expression in bone marrow (RPKM 3.3), lymph node (RPKM 3.1) and 24 other tissues See more
Orthologs
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Genomic context

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See CHEK2 in Genome Data Viewer
Location:
22q12.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (28687743..28741834, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (29149178..29203469, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (29083731..29137822, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene uncharacterized LOC101929594 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:28936993-28937558 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:28948848-28949654 Neighboring gene Sharpr-MPRA regulatory region 11195 Neighboring gene RNA, 7SL, cytoplasmic 162, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29074754-29075258 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:29133817-29134317 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:29132795-29133312 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr22:29132277-29132794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18805 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18806 Neighboring gene Sharpr-MPRA regulatory region 506 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:29168461-29168962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29177710-29178210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29178211-29178711 Neighboring gene coiled-coil domain containing 117 Neighboring gene HscB mitochondrial iron-sulfur cluster cochaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Absence of CHEK2*1100delC mutation in families with hereditary breast cancer in North America. Iniesta MD, et al. Cancer Genet Cytogenet, 2010 Oct 15. PMID 20875877
  2. CHEK2 germline mutations correlate with recurrence rate in patients with superficial bladder cancer. Słojewski M, et al. Ann Acad Med Stetin, 2008. PMID 19839522
  3. A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells. Varmark H, et al. Cell Cycle, 2010 Jan 15. PMID 20023427
  4. Chk2 splice variants express a dominant-negative effect on the wild-type Chk2 kinase activity. Berge EO, et al. Biochim Biophys Acta, 2010 Mar. PMID 20080130
  5. A simple method of investigating mutations in CHEK2 by DHPLC: a study of the German populations of Saxony, Saxony-Anhalt, and Thuringia. Scharrer U, et al. Cancer Genet Cytogenet, 2010 May. PMID 20417869

See all (686) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors.
    Title: Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors.
  2. Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families.
    Title: Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families.
  3. Comprehensive analysis of the functional impact of single nucleotide variants of human CHEK2.
    Title: Comprehensive analysis of the functional impact of single nucleotide variants of human CHEK2.
  4. LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance.
    Title: LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance.
  5. The heterogeneous cancer phenotype of individuals with biallelic germline pathogenic variants in CHEK2.
    Title: The heterogeneous cancer phenotype of individuals with biallelic germline pathogenic variants in CHEK2.
  6. A deep intronic recurrent CHEK2 variant c.1009-118_1009-87delinsC affects pre-mRNA splicing and contributes to hereditary breast cancer predisposition.
    Title: A deep intronic recurrent CHEK2 variant c.1009-118_1009-87delinsC affects pre-mRNA splicing and contributes to hereditary breast cancer predisposition.
  7. Checkpoint kinase 2 controls insulin secretion and glucose homeostasis.
    Title: Checkpoint kinase 2 controls insulin secretion and glucose homeostasis.
  8. CHEK2 Founder Variants and Thyroid Cancer Risk.
    Title: CHEK2 Founder Variants and Thyroid Cancer Risk.
  9. CHEK2 germline variants identified in familial nonmedullary thyroid cancer lead to impaired protein structure and function.
    Title: CHEK2 germline variants identified in familial nonmedullary thyroid cancer lead to impaired protein structure and function.
  10. Germline CHEK2 mutations in patients with myeloid neoplasms.
    Title: Germline CHEK2 mutations in patients with myeloid neoplasms.
Submit: New GeneRIF Correction See all GeneRIFs (490)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Bone osteosarcoma
MedGen: C0585442 OMIM: 259500 GeneReviews: Not available
Compare labs
Li-Fraumeni syndrome 2
MedGen: C5882668 OMIM: 609265 GeneReviews: Not available
Compare labs
Malignant tumor of prostate
MedGen: C0376358 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2020-01-08)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2020-01-08)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study of optic disc parameters.
EBI GWAS Catalog
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
EBI GWAS Catalog
Genetic variants associated with breast size also influence breast cancer risk.
EBI GWAS Catalog
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.
EBI GWAS Catalog
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
EBI GWAS Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
EBI GWAS Catalog
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env PML, TopBP1, NBS1 or ATM-induced activation of phosphorylation of Chk2 participates in the DNA damage-elicited pro-apoptotic cascade that leads to the demise of Env-elicited syncytia PubMed
Vpr vpr Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection PubMed
vpr HIV-1 Vpr induces expression of gamma-H2AX and phosphorylation of Chk2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA damage response TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
  
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
Inferred from Electronic Annotation
more info
  
involved_in G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to bisphenol A IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to gamma radiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair TAS
Traceable Author Statement
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA damage checkpoint IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of anoikis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of autophagosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
  
involved_in replicative senescence NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to glycoside IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction in response to DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thymocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Chk2
Names
CHK2 checkpoint homolog
cds1 homolog
checkpoint-like protein CHK2
NP_001005735.1
NP_001244316.1
NP_001336885.1
NP_009125.1
NP_665861.1
XP_006724177.3
XP_006724179.2
XP_011528141.1
XP_011528142.1
XP_011528144.1
XP_011528146.1
XP_011528147.1
XP_016884049.1
XP_024307916.1
XP_024307917.1
XP_047297060.1
XP_047297061.1
XP_047297062.1
XP_047297063.1
XP_047297064.1
XP_054181012.1
XP_054181013.1
XP_054181014.1
XP_054181015.1
XP_054181016.1
XP_054181017.1
XP_054181018.1
XP_054181019.1
XP_054181020.1
XP_054181021.1
XP_054181022.1
XP_054181023.1
XP_054181024.1
XP_054181025.1
XP_054181026.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008150.2 RefSeqGene

    Range
    5047..59124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_302

mRNA and Protein(s)

  1. NM_001005735.2 → NP_001005735.1  serine/threonine-protein kinase Chk2 isoform c

    See identical proteins and their annotated locations for NP_001005735.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is longer compared to isoform a.
    Source sequence(s)
    AW778747, AY551297, BM838597
    Consensus CDS
    CCDS33629.1
    UniProtKB/TrEMBL
    A8JZZ5
    Related
    ENSP00000372023.2, ENST00000382580.6
    Conserved Domains (2) summary
    cd00060
    Location:156 → 244
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:256 → 529
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  2. NM_001257387.2 → NP_001244316.1  serine/threonine-protein kinase Chk2 isoform d

    See identical proteins and their annotated locations for NP_001244316.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AF217975
    UniProtKB/TrEMBL
    A0A087X102
    Conserved Domains (2) summary
    smart00220
    Location:3 → 265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14084
    Location:1 → 265
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  3. NM_001349956.2 → NP_001336885.1  serine/threonine-protein kinase Chk2 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon, and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) [is shorter/has a distinct C-terminus], compared to isoform a. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF096279, AK290754, AW778747, BX393617
    Consensus CDS
    CCDS93141.1
    UniProtKB/TrEMBL
    A0A7P0MUT5, A8JZZ5
    Related
    ENSP00000384835.2, ENST00000402731.6
    Conserved Domains (1) summary
    cd14084
    Location:162 → 419
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  4. NM_007194.4 → NP_009125.1  serine/threonine-protein kinase Chk2 isoform a

    See identical proteins and their annotated locations for NP_009125.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a.
    Source sequence(s)
    AF096279, AW778747, BM838597
    Consensus CDS
    CCDS13843.1
    UniProtKB/Swiss-Prot
    A8K3Y9, B7ZBF3, B7ZBF4, B7ZBF5, O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HBS5, Q9HCQ8, Q9UGF0, Q9UGF1
    UniProtKB/TrEMBL
    A8JZZ5
    Related
    ENSP00000385747.1, ENST00000404276.6
    Conserved Domains (2) summary
    cd00060
    Location:93 → 201
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:213 → 486
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  5. NM_145862.2 → NP_665861.1  serine/threonine-protein kinase Chk2 isoform b

    See identical proteins and their annotated locations for NP_665861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AW778747, AY551299, BM838597
    Consensus CDS
    CCDS13844.1
    UniProtKB/TrEMBL
    A8JZZ5
    Related
    ENSP00000329012.5, ENST00000348295.7
    Conserved Domains (4) summary
    smart00220
    Location:220 → 457
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1716
    Location:116 → 199
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:93 → 201
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl21453
    Location:213 → 457
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    28687743..28741834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529845.3 → XP_011528147.1  serine/threonine-protein kinase Chk2 isoform X15

    See identical proteins and their annotated locations for XP_011528147.1

    UniProtKB/TrEMBL
    A0A087X102
    Related
    ENSP00000390244.2, ENST00000425190.7
    Conserved Domains (2) summary
    smart00220
    Location:3 → 265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14084
    Location:1 → 265
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  2. XM_047441106.1 → XP_047297062.1  serine/threonine-protein kinase Chk2 isoform X7

  3. XM_047441104.1 → XP_047297060.1  serine/threonine-protein kinase Chk2 isoform X3

  4. XM_047441105.1 → XP_047297061.1  serine/threonine-protein kinase Chk2 isoform X5

  5. XM_011529839.3 → XP_011528141.1  serine/threonine-protein kinase Chk2 isoform X1

    UniProtKB/TrEMBL
    A8JZZ5
    Conserved Domains (2) summary
    cd00060
    Location:166 → 254
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:266 → 539
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  6. XM_024452149.2 → XP_024307917.1  serine/threonine-protein kinase Chk2 isoform X9

    UniProtKB/TrEMBL
    A8JZZ5
    Conserved Domains (2) summary
    cd00060
    Location:103 → 211
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl21453
    Location:223 → 467
    PKc_like; Protein Kinases, catalytic domain

  7. XM_024452148.2 → XP_024307916.1  serine/threonine-protein kinase Chk2 isoform X6

    UniProtKB/TrEMBL
    A8JZZ5
    Conserved Domains (2) summary
    cd00060
    Location:103 → 211
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:223 → 496
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  8. XM_047441107.1 → XP_047297063.1  serine/threonine-protein kinase Chk2 isoform X8

  9. XM_011529840.4 → XP_011528142.1  serine/threonine-protein kinase Chk2 isoform X4

    UniProtKB/TrEMBL
    A8JZZ5
    Conserved Domains (4) summary
    smart00220
    Location:273 → 510
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1716
    Location:123 → 252
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:166 → 254
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl21453
    Location:266 → 510
    PKc_like; Protein Kinases, catalytic domain

  10. XM_011529842.3 → XP_011528144.1  serine/threonine-protein kinase Chk2 isoform X10

    UniProtKB/TrEMBL
    A8JZZ5
    Conserved Domains (2) summary
    smart00220
    Location:172 → 429
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14084
    Location:172 → 429
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  11. XM_017028560.2 → XP_016884049.1  serine/threonine-protein kinase Chk2 isoform X2

    UniProtKB/TrEMBL
    A8JZZ5

  12. XM_047441108.1 → XP_047297064.1  serine/threonine-protein kinase Chk2 isoform X13

  13. XM_006724114.4 → XP_006724177.3  serine/threonine-protein kinase Chk2 isoform X12

    Related
    ENST00000648295.1

  14. XM_006724116.3 → XP_006724179.2  serine/threonine-protein kinase Chk2 isoform X14

    UniProtKB/TrEMBL
    A0A087X102
    Related
    ENSP00000483777.2, ENST00000464581.6
    Conserved Domains (2) summary
    smart00220
    Location:46 → 305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14084
    Location:39 → 305
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  15. XM_011529844.3 → XP_011528146.1  serine/threonine-protein kinase Chk2 isoform X11

    UniProtKB/TrEMBL
    A0AA34QVK6
    Related
    ENSP00000518557.1, ENST00000711048.1
    Conserved Domains (4) summary
    smart00220
    Location:273 → 390
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1716
    Location:123 → 252
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:166 → 254
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl21453
    Location:266 → 390
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_937806.3 RNA Sequence

  2. XR_007067955.1 RNA Sequence

  3. XR_007067954.1 RNA Sequence

  4. XR_937807.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    29149178..29203469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325051.1 → XP_054181026.1  serine/threonine-protein kinase Chk2 isoform X15

  2. XM_054325043.1 → XP_054181018.1  serine/threonine-protein kinase Chk2 isoform X7

  3. XM_054325039.1 → XP_054181014.1  serine/threonine-protein kinase Chk2 isoform X3

  4. XM_054325041.1 → XP_054181016.1  serine/threonine-protein kinase Chk2 isoform X5

  5. XM_054325037.1 → XP_054181012.1  serine/threonine-protein kinase Chk2 isoform X1

  6. XM_054325045.1 → XP_054181020.1  serine/threonine-protein kinase Chk2 isoform X9

  7. XM_054325042.1 → XP_054181017.1  serine/threonine-protein kinase Chk2 isoform X6

  8. XM_054325044.1 → XP_054181019.1  serine/threonine-protein kinase Chk2 isoform X8

  9. XM_054325040.1 → XP_054181015.1  serine/threonine-protein kinase Chk2 isoform X4

  10. XM_054325046.1 → XP_054181021.1  serine/threonine-protein kinase Chk2 isoform X10

  11. XM_054325038.1 → XP_054181013.1  serine/threonine-protein kinase Chk2 isoform X2

  12. XM_054325049.1 → XP_054181024.1  serine/threonine-protein kinase Chk2 isoform X17

  13. XM_054325048.1 → XP_054181023.1  serine/threonine-protein kinase Chk2 isoform X16

  14. XM_054325050.1 → XP_054181025.1  serine/threonine-protein kinase Chk2 isoform X14

  15. XM_054325047.1 → XP_054181022.1  serine/threonine-protein kinase Chk2 isoform X11

RNA

  1. XR_008485362.1 RNA Sequence

  2. XR_008485364.1 RNA Sequence

  3. XR_008485361.1 RNA Sequence

  4. XR_008485363.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O96017.1 GenPept UniProtKB/Swiss-Prot:O96017

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