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Srsf1 serine and arginine-rich splicing factor 1 [ Mus musculus (house mouse) ]

Gene ID: 110809, updated on 12-Nov-2024

Summary

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Official Symbol
Srsf1provided by MGI
Official Full Name
serine and arginine-rich splicing factor 1provided by MGI
Primary source
MGI:MGI:98283
See related
Ensembl:ENSMUSG00000018379 AllianceGenome:MGI:98283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asf; Sf2; Sfrs1; 1110054N12Rik; 5730507C05Rik; 6330415C05Rik
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 77.9), CNS E14 (RPKM 62.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Srsf1 in Genome Data Viewer
Location:
11 C; 11 52.4 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87937325..87944583)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88046499..88053757)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dynein light chain LC8-type 2 Neighboring gene predicted gene, 38610 Neighboring gene STARR-positive B cell enhancer ABC_E9835 Neighboring gene STARR-seq mESC enhancer starr_30308 Neighboring gene vascular endothelial zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87905511-87905664 Neighboring gene RIKEN cDNA 2210416O15 gene Neighboring gene CUE domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ASF alternative transcripts are highly conserved between mouse and man. Tacke R, et al. Nucleic Acids Res, 1992 Oct 25. PMID 1437571, Free PMC Article
  2. SRSF1 serves as a critical posttranscriptional regulator at the late stage of thymocyte development. Qi Z, et al. Sci Adv, 2021 Apr. PMID 33863728, Free PMC Article
  3. Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function. Haward F, et al. Elife, 2021 Aug 2. PMID 34338635, Free PMC Article
  4. SRSF1 plays a critical role in invariant natural killer T cell development and function. Liu J, et al. Cell Mol Immunol, 2021 Nov. PMID 34522020, Free PMC Article
  5. Splicing factor SRSF1 controls distinct molecular programs in regulatory and effector T cells implicated in systemic autoimmune disease. Cassidy MF, et al. Mol Immunol, 2022 Jan. PMID 34839165, Free PMC Article

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA MAAMT facilitates macrophage recruitment and proinflammatory activation and exacerbates autoimmune myocarditis through the SRSF1/NF-kappaB axis.
    Title: LncRNA MAAMT facilitates macrophage recruitment and proinflammatory activation and exacerbates autoimmune myocarditis through the SRSF1/NF-κB axis.
  2. SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic Function in Brown Adipocytes Through its Control of Ndufs3 Splicing.
    Title: SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic Function in Brown Adipocytes Through its Control of Ndufs3 Splicing.
  3. Truncated Dyrk1A aggravates neuronal apoptosis by inhibiting ASF-mediated Bcl-x exon 2b inclusion.
    Title: Truncated Dyrk1A aggravates neuronal apoptosis by inhibiting ASF-mediated Bcl-x exon 2b inclusion.
  4. Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice.
    Title: Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice.
  5. SRSF1 is essential for primary follicle development by regulating granulosa cell survival via mRNA alternative splicing.
    Title: SRSF1 is essential for primary follicle development by regulating granulosa cell survival via mRNA alternative splicing.
  6. Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression.
    Title: Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression.
  7. Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer.
    Title: Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer.
  8. SRSF1 is crucial for male meiosis through alternative splicing during homologous pairing and synapsis in mice.
    Title: SRSF1 is crucial for male meiosis through alternative splicing during homologous pairing and synapsis in mice.
  9. SRSF1 regulates primordial follicle formation and number determination during meiotic prophase I.
    Title: SRSF1 regulates primordial follicle formation and number determination during meiotic prophase I.
  10. Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death.
    Title: Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA topoisomerase binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RS domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables molecular function regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase B binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within RNA splicing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cardiac muscle contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to interleukin-17 IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-17-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA 5'-splice site recognition ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA 5'-splice site recognition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to P-body IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction involved in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/arginine-rich splicing factor 1
Names
ASF/SF2
pre-mRNA-splicing factor SRp30a
splicing factor, arginine/serine-rich 1 (ASF/SF2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001078167.2 → NP_001071635.1  serine/arginine-rich splicing factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001071635.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK053674, AK078715, AL593853, CF739274
    Consensus CDS
    CCDS36274.1
    UniProtKB/Swiss-Prot
    Q6PDM2
    Related
    ENSMUSP00000133517.2, ENSMUST00000079866.11
    Conserved Domains (3) summary
    COG0724
    Location:8 → 88
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12597
    Location:17 → 90
    RRM1_SRSF1; RNA recognition motif 1 in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
    cl17169
    Location:121 → 190
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_173374.4 → NP_775550.2  serine/arginine-rich splicing factor 1 isoform 1

    See identical proteins and their annotated locations for NP_775550.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK053674, AL593853, CF739274
    Consensus CDS
    CCDS36273.1
    UniProtKB/Swiss-Prot
    B2KGJ5, Q3UCH2, Q5SXC5, Q6PDM2, Q8BJV3, Q8C1H9
    Related
    ENSMUSP00000120595.3, ENSMUST00000139129.9
    Conserved Domains (2) summary
    cd12597
    Location:12 → 90
    RRM1_SRSF1; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
    cd12767
    Location:113 → 196
    RRM2_SRSF1; RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87937325..87944583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_388324.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDM2.3 GenPept UniProtKB/Swiss-Prot:Q6PDM2

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