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UTS2 urotensin 2 [ Homo sapiens (human) ]

Gene ID: 10911, updated on 2-Nov-2024

Summary

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Official Symbol
UTS2provided by HGNC
Official Full Name
urotensin 2provided by HGNC
Primary source
HGNC:HGNC:12636
See related
Ensembl:ENSG00000049247 MIM:604097; AllianceGenome:HGNC:12636
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UII; U-II; UCN2; PRO1068
Summary
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See UTS2 in Genome Data Viewer
Location:
1p36.23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (7847612..7913249, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (7378659..7444444, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (7907672..7913551, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 186 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:7831283-7831525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 187 Neighboring gene vesicle associated membrane protein 3 Neighboring gene period circadian regulator 3 Neighboring gene uncharacterized LOC124903833 Neighboring gene MPRA-validated peak42 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7886590-7887789 Neighboring gene NANOG hESC enhancer GRCh37_chr1:7912645-7913333 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:7929285-7930484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7935645-7936144 Neighboring gene NANOG hESC enhancer GRCh37_chr1:7970949-7971450 Neighboring gene tRNA-undetermined (NNN) 4-1 Neighboring gene TNF receptor superfamily member 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 92 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 93 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:8020839-8021622 and GRCh37_chr1:8021623-8022406 Neighboring gene Parkinsonism associated deglycase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evidence for heterodimerization and functional interaction of the urotensin II and the angiotensin II type 1 receptors.
    Title: Evidence for heterodimerization and functional interaction of the urotensin II and the angiotensin II type 1 receptors.
  2. Serum Urotensin II Levels Are Elevated in Patients with Obstructive Sleep Apnea.
    Title: Serum Urotensin II Levels Are Elevated in Patients with Obstructive Sleep Apnea.
  3. Urotensin II level is elevated in inflammatory bowel disease patients.
    Title: Urotensin II level is elevated in inflammatory bowel disease patients.
  4. Role of miR-146a rs2910164 and UTS2 rs228648 Genetic Variants in Behcet's Disease.
    Title: Role of miR-146a rs2910164 and UTS2 rs228648 Genetic Variants in Behçet's Disease.
  5. Dynamic Changes in Plasma Urotensin II and Its Correlation With Plaque Stability.
    Title: Dynamic Changes in Plasma Urotensin II and Its Correlation With Plaque Stability.
  6. Expression of urotensin II is positively correlated with pyroptosis-related molecules in patients with severe preeclampsia.
    Title: Expression of urotensin II is positively correlated with pyroptosis-related molecules in patients with severe preeclampsia.
  7. Association of resistin (rs3745367) and urotensin II (rs228648 and rs2890565) gene polymorphisms with risk of type 2 diabetes mellitus in Indian population.
    Title: Association of resistin (rs3745367) and urotensin II (rs228648 and rs2890565) gene polymorphisms with risk of type 2 diabetes mellitus in Indian population.
  8. Urotensin-II, oxidative stress, and inflammation increase in hypertensive and resistant hypertensive patients.
    Title: Urotensin-II, oxidative stress, and inflammation increase in hypertensive and resistant hypertensive patients.
  9. positive correlation with autophagic marker LC3II in placentas of preeclampsia patients
    Title: Expression of urotensin II is associated with placental autophagy in patients with severe preeclampsia.
  10. Study findings suggest that UT-2 has a high potential as a vasoconstrictor agent in human bodies and its level increases through a bolus or continuous infusion of 5-fluorouracil (5-FU). Increased UT-2 levels are likely to play a role in 5-FU-related cardiac toxicity pathogenesis.
    Title: Role of Urotensin-2 in 5-Fluorouracil-Related Arterial Vasoconstriction in Cancer Patients.
Submit: New GeneRIF Correction See all GeneRIFs (92)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood vessel diameter maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
urotensin-2
Names
prepro U-II
urotensin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006786.4 → NP_006777.1  urotensin-2 isoform b preproprotein

    See identical proteins and their annotated locations for NP_006777.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes a shorter preproprotein isoform (b) of 124 amino acids with a different amino-terminal end compared to isoform a. The mature peptide is identical for both transcript variants.
    Source sequence(s)
    AF104118, AY358375, Z98884
    Consensus CDS
    CCDS91.1
    UniProtKB/Swiss-Prot
    O95399, Q5H8X7, Q6UXF6, Q9UKP7
    UniProtKB/TrEMBL
    Q5H8X8
    Related
    ENSP00000355163.5, ENST00000361696.10
    Conserved Domains (1) summary
    pfam02083
    Location:113 → 124
    Urotensin_II; Urotensin II

  2. NM_021995.2 → NP_068835.1  urotensin-2 isoform a preproprotein

    See identical proteins and their annotated locations for NP_068835.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a longer preproprotein isoform (a) of 139 amino acids with a different amino-terminal end compared to isoform b. The mature peptide is identical for both transcript variants.
    Source sequence(s)
    AF140630, AY358375, BC126443
    Consensus CDS
    CCDS90.1
    UniProtKB/Swiss-Prot
    O95399
    UniProtKB/TrEMBL
    A0AVP6
    Related
    ENSP00000054668.5, ENST00000054668.5
    Conserved Domains (1) summary
    pfam02083
    Location:128 → 139
    Urotensin_II; Urotensin II

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    7847612..7913249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540537.3 → XP_011538839.1  urotensin-2 isoform X1

    See identical proteins and their annotated locations for XP_011538839.1

    UniProtKB/Swiss-Prot
    O95399
    Conserved Domains (1) summary
    pfam02083
    Location:128 → 139
    Urotensin_II; Urotensin II

  2. XM_011540538.2 → XP_011538840.1  urotensin-2 isoform X2

    See identical proteins and their annotated locations for XP_011538840.1

    UniProtKB/Swiss-Prot
    O95399, Q5H8X7, Q6UXF6, Q9UKP7
    UniProtKB/TrEMBL
    Q5H8X8
    Conserved Domains (1) summary
    pfam02083
    Location:113 → 124
    Urotensin_II; Urotensin II

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    7378659..7444444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333954.1 → XP_054189929.1  urotensin-2 isoform X1

  2. XM_054333955.1 → XP_054189930.1  urotensin-2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95399.1 GenPept UniProtKB/Swiss-Prot:O95399

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