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Stn1 STN1, CST complex subunit [ Mus musculus (house mouse) ]

Gene ID: 108689, updated on 14-Nov-2024

Summary

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Official Symbol
Stn1provided by MGI
Official Full Name
STN1, CST complex subunitprovided by MGI
Primary source
MGI:MGI:1915581
See related
Ensembl:ENSMUSG00000042694 AllianceGenome:MGI:1915581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AAF44; Obfc1; AAF-44; RPA-32; 0610009H20Rik; 2310057J23Rik
Summary
Enables single-stranded DNA binding activity and telomeric DNA binding activity. Involved in positive regulation of DNA replication. Located in chromosome, telomeric region and nucleus. Part of CST complex. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human STN1 (STN1 subunit of CST complex). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 8.0), CNS E11.5 (RPKM 7.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stn1 in Genome Data Viewer
Location:
19 C3; 19 39.64 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47489470..47534284, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47501031..47545845, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene SH3 and PX domains 2A Neighboring gene predicted gene, 52384 Neighboring gene STARR-seq mESC enhancer starr_46363 Neighboring gene predicted gene, 41858 Neighboring gene STARR-positive B cell enhancer ABC_E5709 Neighboring gene predicted gene, 19557 Neighboring gene STARR-seq mESC enhancer starr_46366 Neighboring gene STE20-like kinase Neighboring gene predicted gene 16068 Neighboring gene collagen, type XVII, alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair. Nguyen DD, et al. Sci Adv, 2023 May 10. PMID 37163605, Free PMC Article
  2. OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. Wan M, et al. J Biol Chem, 2009 Sep 25. PMID 19648609, Free PMC Article
  3. A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. Casteel DE, et al. J Biol Chem, 2009 Feb 27. PMID 19119139, Free PMC Article
  4. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Miyake Y, et al. Mol Cell, 2009 Oct 23. PMID 19854130
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.
    Title: Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.
  2. OBFC1 is identical to the previously described 44 kDa subunit of DNA-pol-alpha/primase associated factor (AAF) which increases polymerase-alpha/primase template affinity and stimulate both DNA primase and polymerase-alpha activities in vitro.
    Title: A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded telomeric DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in telomere capping IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomere lengthening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomere lengthening ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of CST complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CST complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CST complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CST complex subunit STN1
Names
alpha accessory factor 44
alpha-accessory factor of 44 kDa
oligonucleotide/oligosaccharide-binding fold containing 1
oligonucleotide/oligosaccharide-binding fold-containing protein 1
replication protein A 32 kDa subunit
suppressor of cdc thirteen homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175360.3 → NP_780569.1  CST complex subunit STN1

    See identical proteins and their annotated locations for NP_780569.1

    Status: VALIDATED

    Source sequence(s)
    AC125075, AK075574, AK164386
    Consensus CDS
    CCDS29892.1
    UniProtKB/Swiss-Prot
    Q3TPH0, Q8C6I6, Q8K2X3
    Related
    ENSMUSP00000040944.9, ENSMUST00000049369.16
    Conserved Domains (2) summary
    cd04483
    Location:65 → 165
    hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...
    pfam09170
    Location:167 → 343
    STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    47489470..47534284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250695.1 → XP_030106555.1  CST complex subunit STN1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TPH0, Q8C6I6, Q8K2X3
    Conserved Domains (2) summary
    cd04483
    Location:65 → 165
    hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...
    pfam09170
    Location:167 → 343
    STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1

  2. XM_006526598.4 → XP_006526661.1  CST complex subunit STN1 isoform X2

    See identical proteins and their annotated locations for XP_006526661.1

    UniProtKB/TrEMBL
    Q3UXU8
    Related
    ENSMUSP00000138727.2, ENSMUST00000182808.8
    Conserved Domains (2) summary
    cd04483
    Location:65 → 165
    hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...
    pfam09170
    Location:167 → 326
    STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2X3.2 GenPept UniProtKB/Swiss-Prot:Q8K2X3

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