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Grm5 glutamate receptor, metabotropic 5 [ Mus musculus (house mouse) ]

Gene ID: 108071, updated on 18-Sep-2024

Summary

Official Symbol
Grm5provided by MGI
Official Full Name
glutamate receptor, metabotropic 5provided by MGI
Primary source
MGI:MGI:1351342
See related
Ensembl:ENSMUSG00000049583 AllianceGenome:MGI:1351342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glu5R; Gprc1e; mGluR5; mGluR5b; 6430542K11Rik
Summary
Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; and modulation of age-related behavioral decline. Acts upstream of or within learning; locomotory behavior; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including Schaffer collateral - CA1 synapse; neuron projection; and plasma membrane. Is expressed in central nervous system and retina. Used to study schizophrenia. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 10.5), frontal lobe adult (RPKM 8.7) and 4 other tissues See more
Orthologs
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Genomic context

See Grm5 in Genome Data Viewer
Location:
7 D3; 7 49.01 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (87233212..87784271)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (87583981..88135063)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19473 Neighboring gene tyrosinase Neighboring gene tyrosinase locus control region Neighboring gene predicted gene, 57515 Neighboring gene tyrosinase CNS-2 distal regulatory element Neighboring gene splicing factor 3a, subunit 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19475 Neighboring gene STARR-seq mESC enhancer starr_19477 Neighboring gene predicted gene, 24249 Neighboring gene STARR-positive B cell enhancer ABC_E1737 Neighboring gene STARR-seq mESC enhancer starr_19478 Neighboring gene STARR-positive B cell enhancer ABC_E8841 Neighboring gene STARR-seq mESC enhancer starr_19480 Neighboring gene STARR-positive B cell enhancer ABC_E1344 Neighboring gene cathepsin C Neighboring gene predicted gene, 25345

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables A2A adenosine receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables A2A adenosine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
enables PLC activating G protein-coupled glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase activator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium-mediated signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in astrocyte projection IEA
Inferred from Electronic Annotation
more info
 
located_in astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metabotropic glutamate receptor 5
Names
G protein-coupled receptor GRM5
G protein-coupled receptor, family C, group 1, member E
metabotropic glutamate receptor subtype 5b
metabotropic glutamate receptor type 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081414.2NP_001074883.1  metabotropic glutamate receptor 5 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) lacks an alternate in-frame exon in the 3' coding region, compared to variant b. The resulting isoform (a) lacks a segment near the C-terminus, compared to isoform b.
    Source sequence(s)
    AC113033, BC096533, BC144727, BY721282, CJ124875
    Consensus CDS
    CCDS40013.1
    UniProtKB/TrEMBL
    B7ZMP7, E9QMC2, F6WSV0
    Related
    ENSMUSP00000118393.3, ENSMUST00000125009.9
    Conserved Domains (5) summary
    PHA03247
    Location:9501154
    PHA03247; large tegument protein UL36; Provisional
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11221171
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  2. NM_001143834.1NP_001137306.1  metabotropic glutamate receptor 5 isoform b precursor

    See identical proteins and their annotated locations for NP_001137306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) represents the longer transcript and encodes the longer isoform (b).
    Source sequence(s)
    AC113033, AC116820, BC096533, BY721282, CJ124875
    Consensus CDS
    CCDS52305.1
    UniProtKB/Swiss-Prot
    Q3UVX5
    UniProtKB/TrEMBL
    B2BH30, B7ZMP7, F6YJ89
    Conserved Domains (5) summary
    PHA03247
    Location:9821186
    PHA03247; large tegument protein UL36; Provisional
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11541203
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    87233212..87784271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152559.1XP_036008452.1  metabotropic glutamate receptor 5 isoform X1

    UniProtKB/Swiss-Prot
    Q3UVX5
    UniProtKB/TrEMBL
    B2BH30, B7ZMP7, F6YJ89
    Conserved Domains (5) summary
    PHA03247
    Location:9821186
    PHA03247; large tegument protein UL36; Provisional
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11541203
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  2. XM_011241643.4XP_011239945.1  metabotropic glutamate receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_011239945.1

    UniProtKB/Swiss-Prot
    Q3UVX5
    UniProtKB/TrEMBL
    B2BH30, B7ZMP7, F6YJ89
    Conserved Domains (5) summary
    PHA03247
    Location:9821186
    PHA03247; large tegument protein UL36; Provisional
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11541203
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  3. XM_036152560.1XP_036008453.1  metabotropic glutamate receptor 5 isoform X1

    UniProtKB/Swiss-Prot
    Q3UVX5
    UniProtKB/TrEMBL
    B2BH30, B7ZMP7, F6YJ89
    Related
    ENSMUSP00000114927.3, ENSMUST00000155358.3
    Conserved Domains (5) summary
    PHA03247
    Location:9821186
    PHA03247; large tegument protein UL36; Provisional
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11541203
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  4. XM_036152561.1XP_036008454.1  metabotropic glutamate receptor 5 isoform X2

    UniProtKB/TrEMBL
    B7ZMP7, E9QMC2, F6WSV0
    Conserved Domains (5) summary
    PHA03247
    Location:9501154
    PHA03247; large tegument protein UL36; Provisional
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11221171
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  5. XM_036152562.1XP_036008455.1  metabotropic glutamate receptor 5 isoform X2

    UniProtKB/TrEMBL
    B7ZMP7, E9QMC2, F6WSV0
    Related
    ENSMUSP00000102884.3, ENSMUST00000107263.9
    Conserved Domains (5) summary
    PHA03247
    Location:9501154
    PHA03247; large tegument protein UL36; Provisional
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11221171
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  6. XM_006507184.5XP_006507247.1  metabotropic glutamate receptor 5 isoform X3

    UniProtKB/TrEMBL
    Q4VA56
    Conserved Domains (3) summary
    cd15450
    Location:577826
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:507557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06374
    Location:26496
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033224.1: Suppressed sequence

    Description
    NM_001033224.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.