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TLL2 tolloid-like 2 [ Gallus gallus (chicken) ]

Gene ID: 107053676, updated on 17-Aug-2024

Summary

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Symbol
TLL2provided by CGNC
Full Name
tolloid-like 2provided by CGNC
Primary source
CGNC:4111
See related
Ensembl:ENSGALG00010021803
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See TLL2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (17355106..17437534, complement)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 2C18 like Neighboring gene cytochrome P450 family 2 subfamily C member 18 Neighboring gene Fas apoptotic inhibitory molecule pseudogene Neighboring gene transmembrane 9 superfamily member 3 Neighboring gene uncharacterized LOC107053675

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_052537.1 Chromosome 6 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tolloid-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    17355106..17437534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015288521.4 → XP_015144007.2  tolloid-like protein 2

    UniProtKB/TrEMBL
    A0A8V0ZF88, A0A8V0ZF94
    Related
    ENSGALP00010031961.1, ENSGALT00010053067.1
    Conserved Domains (4) summary
    smart00179
    Location:565 → 606
    EGF_CA; Calcium-binding EGF-like domain
    cd00041
    Location:609 → 720
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd04281
    Location:139 → 338
    ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
    cl00057
    Location:703 → 757
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein Strain
Heading Accession and Version

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