ARL6IP5 ARF like GTPase 6 interacting protein 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARL6IP5provided by HGNC
Official Full Name: ARF like GTPase 6 interacting protein 5provided by HGNC
Primary source: HGNC:HGNC:16937
See related: Ensembl:ENSG00000144746 MIM:605709; AllianceGenome:HGNC:16937
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JWA; jmx; hp22; PRAF3; Yip6b; DERP11; HSPC127; addicsin; GTRAP3-18
Summary: Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in fat (RPKM 104.3), heart (RPKM 86.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p14.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (69084937..69106092)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (69121729..69142904)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (69134088..69155243)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma.
Title: ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma.
Correlation between JWA gene polymorphism and acute lymphoblastic leukemia.
Title: Correlation between JWA gene polymorphism and acute lymphoblastic leukemia.
These data demonstrated that JWA suppressed the migration/invasion of breast carcinoma cells by downregulating the expression of CXCR4, and suggested that JWA may harbor prognostic and therapeutic potential in patients with breast cancer.
Title: JWA suppresses the invasion of human breast carcinoma cells by downregulating the expression of CXCR4.
increased RNF185 expression facilitated GC cell migration in vitro and promoted GC metastasis in vivo by downregulating JWA expression.
Title: RNF185 modulates JWA ubiquitination and promotes gastric cancer metastasis.
our results demonstrate that JWA is a novel negative regulator of HER2 expression...in HER2-positive gastric cancer cells
Title: JWA loss promotes cell migration and cytoskeletal rearrangement by affecting HER2 expression and identifies a high-risk subgroup of HER2-positive gastric carcinoma patients.
Protective effect of JWA against paraquat neurotoxicity involves regulation of the MEK/PI3K-Nrf2 axis.
Title: JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.
JWA and topoisomerase II alpha regulate each other in tumor cells arrested in G2/M.
Title: EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells.
the JWA gene may regulate human breast cancer cells through the MAPK signaling pathway using different types of regulation.
Title: Effects of the JWA gene in the regulation of human breast cancer cells.
This review gives an overview of EAAC1-mediated GSH synthesis, and its regulatory mechanisms by GTRAP3-18 in the brain, and a potential approach against neurodegeneration.
Title: Inhibition of GTRAP3-18 may increase neuroprotective glutathione (GSH) synthesis.
JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells.
Title: JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-33714 (e-PCR)
- UniSTS:81439

SHGC-77077 (e-PCR)
- UniSTS:80563

SHGC-52890 (e-PCR)
- UniSTS:75987

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in L-glutamate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of L-glutamate import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PRA1 family protein 3

Names: ADP ribosylation factor like GTPase 6 interacting protein 5; ADP-ribosylation factor GTPase 6 interacting protein 5; ADP-ribosylation factor-like 6 interacting protein 5; ADP-ribosylation factor-like protein 6-interacting protein 5; ADP-ribosylation-like factor 6 interacting protein 5; ARL-6-interacting protein 5; JM5; PRA1 domain family 3; aip-5; cytoskeleton-related vitamin A-responsive protein; dermal papilla derived protein 11; glutamate transporter EAAC1-interacting protein; glutamate transporter EEAC1-associated protein; prenylated Rab acceptor protein 2; protein JWa; putative MAPK activating protein PM27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.