U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Txndc5 thioredoxin domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 105245, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Txndc5provided by MGI
Official Full Name
thioredoxin domain containing 5provided by MGI
Primary source
MGI:MGI:2145316
See related
Ensembl:ENSMUSG00000038991 AllianceGenome:MGI:2145316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERp46; PC-TRP
Summary
Predicted to enable protein disulfide isomerase activity. Predicted to be involved in apoptotic cell clearance. Located in endoplasmic reticulum lumen. Is expressed in several structures, including brain; immune system; intestine; male reproductive gland or organ; and urinary system. Orthologous to human TXNDC5 (thioredoxin domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 145.4), adrenal adult (RPKM 131.5) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
13 A3.3; 13 18.27 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38684242..38712800, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38500266..38528824, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47990 Neighboring gene bone morphogenetic protein 6 Neighboring gene RIKEN cDNA 4930579J19 gene Neighboring gene STARR-seq mESC enhancer starr_34248 Neighboring gene predicted gene, 31834 Neighboring gene predicted gene, 40922 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 5, muted Neighboring gene STARR-seq mESC enhancer starr_34249

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Role of ERp46 in β-cell lipoapoptosis through endoplasmic reticulum stress pathway as well as the protective effect of exendin-4. Chen DL, et al. Biochem Biophys Res Commun, 2012 Sep 28. PMID 22935416
  2. Proteomics and gene expression analyses of squalene-supplemented mice identify microsomal thioredoxin domain-containing protein 5 changes associated with hepatic steatosis. Ramírez-Torres A, et al. J Proteomics, 2012 Dec 21. PMID 22796066
  3. Involvement of thioredoxin domain-containing 5 in resistance to nitrosative stress. Lee HW, et al. Free Radic Biol Med, 2010 Sep 1. PMID 20550962
  4. ERp46 is reduced by high glucose and regulates insulin content in pancreatic beta-cells. Alberti A, et al. Am J Physiol Endocrinol Metab, 2009 Sep. PMID 19622788
  5. Identification of a novel thioredoxin-related protein, PC-TRP, which is preferentially expressed in plasma cells. Wrammert J, et al. Eur J Immunol, 2004 Jan. PMID 14971039

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way.
    Title: Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way.
  2. A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice.
    Title: A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice.
  3. Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-beta signaling in kidney fibroblasts.
    Title: Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts.
  4. Inhibition of ER stress by targeting the IRE1alpha-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
    Title: Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
  5. Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFbeta signaling through TGFBR1 stabilization.
    Title: Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
  6. TXNDC5 mRNA and protein were highly upregulated in hypertrophied/failing mouse left ventricle. Targeted disruption of Txndc5 in mice revealed protective effects against isoproterenol-induced cardiac hypertrophy, reduced fibrosis by approximately 70%, and markedly improved left ventricle function.
    Title: Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.
  7. Hypoxia induced TXCNDC5 expression, which contributed to adiponectin expression, cytokine production and the cellular proliferation and migration of fibroblasts in rheumatoid arthritis.
    Title: Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis.
  8. Txndc5 reflects the anti-steatotic properties of squalene and the sensitivity to lipid accumulation.
    Title: Proteomics and gene expression analyses of squalene-supplemented mice identify microsomal thioredoxin domain-containing protein 5 changes associated with hepatic steatosis.
  9. ERp46 plays a protective role in palmitic acid -induced cell apoptosis by decreasing the endoplasmic reticulum stress response and might be a novel target for anti-diabetic drugs.
    Title: Role of ERp46 in β-cell lipoapoptosis through endoplasmic reticulum stress pathway as well as the protective effect of exendin-4.
  10. Potential role for TXNDC5 in resistance to nitrosative stress.
    Title: Involvement of thioredoxin domain-containing 5 in resistance to nitrosative stress.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein-disulfide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
thioredoxin domain-containing protein 5
Names
ER protein 46
endoplasmic reticulum protein ERp46
endoplasmic reticulum resident protein 46
plasma cell-specific thioredoxin-related protein
thioredoxin-like protein p46
NP_001276527.1
NP_001276528.1
NP_663342.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289598.1 → NP_001276527.1  thioredoxin domain-containing protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001276527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and represents translation initiation at an in-frame downstream AUG, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154747, AK136046, AK224956, AY243534
    Consensus CDS
    CCDS79178.1
    UniProtKB/TrEMBL
    A0A0R4J1Y7, Q3UWX1
    Related
    ENSMUSP00000124516.2, ENSMUST00000162075.8
    Conserved Domains (3) summary
    cd03005
    Location:82 → 182
    PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
    TIGR01130
    Location:85 → 323
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    cl00388
    Location:2 → 56
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  2. NM_001289599.1 → NP_001276528.1  thioredoxin domain-containing protein 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and coding region and represents translation initiation at a novel AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK225017, AY243534
    Consensus CDS
    CCDS79179.1
    UniProtKB/TrEMBL
    E9PXX7, Q3UBW8
    Related
    ENSMUSP00000124401.2, ENSMUST00000160653.2
    Conserved Domains (3) summary
    cd03005
    Location:103 → 203
    PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
    TIGR01130
    Location:2 → 344
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    cl00388
    Location:2 → 77
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. NM_145367.4 → NP_663342.3  thioredoxin domain-containing protein 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_663342.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK224971, AK225023, AY243534
    Consensus CDS
    CCDS26463.1
    UniProtKB/Swiss-Prot
    Q8R1I6, Q91W90
    UniProtKB/TrEMBL
    Q3TEE8, Q3UBW8
    Related
    ENSMUSP00000041839.9, ENSMUST00000035988.16
    Conserved Domains (2) summary
    cd03005
    Location:176 → 276
    PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
    TIGR01130
    Location:52 → 417
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    38684242..38712800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91W90.2 GenPept UniProtKB/Swiss-Prot:Q91W90

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous