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LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [ Homo sapiens (human) ]

Gene ID: 102724971, updated on 21-Sep-2024

Summary

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Gene symbol
LOC102724971
Gene description
putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
Gene type
protein coding
RefSeq status
MODEL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGH; IgA; IGH@; IGVH; ighv; IGHV4; IGHV@; V4-4b; IGHV4-4; IGHV4-04
Expression
Biased expression in urinary bladder (RPKM 104.3), stomach (RPKM 19.2) and 7 other tissues See more
Orthologs
all
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Genomic context

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See LOC102724971 in Genome Data Viewer
Location:
15q11.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (21742069..21742888, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy variable 1/OR15-1 pseudogene Neighboring gene immunoglobulin heavy variable 1/OR15-3 (pseudogene) Neighboring gene uncharacterized LOC105379208 Neighboring gene uncharacterized LOC105379207

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations. Dussupt V, et al. Nat Immunol, 2021 Dec. PMID 34716452, Free PMC Article
  2. Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant. Graham C, et al. Immunity, 2021 Jun 8. PMID 33836142, Free PMC Article
  3. Prolonged evolution of the human B cell response to SARS-CoV-2 infection. Sakharkar M, et al. Sci Immunol, 2021 Feb 23. PMID 33622975, Free PMC Article
  4. Complete sequence of the genes encoding the VH and VL regions of low- and high-affinity monoclonal IgM and IgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient. Harindranath N, et al. Int Immunol, 1991 Sep. PMID 1718404, Free PMC Article
  5. Bone marrow cells in X-linked agammaglobulinemia express pre-B-specific genes (lambda-like and V pre-B) and present immunoglobulin V-D-J gene usage strongly biased to a fetal-like repertoire. Milili M, et al. J Clin Invest, 1993 Apr. PMID 8473505, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Homology

General protein information

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Preferred Names
putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
Names
Ig H-chain V-region (DP-69)
Ig heavy chain gene variable region V(11)
Ig-H chain VDJ-region (or 3)
anti-SARS-CoV-2 immunoglobulin heavy chain variable region
anti-ZIKV immunoglobulin heavy chain variable region
circulating B cell antibody heavy chain variable region
immunoglobulin G heavy chain variable region
immunoglobulin alpha heavy chain variable region
immunoglobulin heavy chain CDR3
immunoglobulin heavy chain V region
immunoglobulin heavy chain VHDJ region
immunoglobulin heavy chain variable region
immunoglobulin mu heavy chain variable region
immunoglobulin variable region
immunoglobulin variable region heavy chain
rotavirus-specific intestinal-homing antibody heavy chain variable region

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    21742069..21742888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543804.4 → XP_011542106.1  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8

    See identical proteins and their annotated locations for XP_011542106.1

    Conserved Domains (2) summary
    smart00410
    Location:33 → 123
    IG_like; Immunoglobulin like
    cl11960
    Location:30 → 125
    Ig; Immunoglobulin domain

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160017.1 Reference GRCh38.p14 PATCHES

    Range
    2331229..2332048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443226.1 → XP_047299182.1  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8

Nucleotide Protein
Heading Accession and Version

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