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MITF melanocyte inducing transcription factor [ Bubalus bubalis (water buffalo) ]

Gene ID: 102399004, updated on 19-Aug-2024

Summary

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Gene symbol
MITF
Gene description
melanocyte inducing transcription factor
See related
EnsemblRapid:ENSBALG00030013353
Gene type
protein coding
RefSeq status
MODEL
Organism
Bubalus bubalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bubalus
Orthologs
human mouse all
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Genomic context

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See MITF in Genome Data Viewer
Location:
chromosome: 21
Exon count:
13
Annotation release Status Assembly Chr Location
103 current NDDB_SH_1 (GCF_019923935.1) 21 NC_059177.1 (31544437..31775071, complement)
102 previous assembly NDDB_DH_1 (GCF_019923925.1) 21 NC_058363.1 (31255616..31486102, complement)

Chromosome 21 - NC_059177.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S25-like Neighboring gene uncharacterized LOC123465260 Neighboring gene uncharacterized LOC112581276 Neighboring gene FERM domain containing 4B Neighboring gene ras-related protein Rab-2B-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microphthalmia-associated transcription factor mutations are associated with white-spotted coat color in swamp buffalo. Yusnizar Y, et al. Anim Genet, 2015 Dec. PMID 26417640, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genomic analysis reveals the association of KIT and MITF variants with the white spotting in swamp buffaloes.
    Title: Genomic analysis reveals the association of KIT and MITF variants with the white spotting in swamp buffaloes.
  2. identified two MITF mutations associated with the white-spotted coat color phenotype in swamp buffaloes
    Title: Microphthalmia-associated transcription factor mutations are associated with white-spotted coat color in swamp buffalo.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in melanocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
microphthalmia-associated transcription factor
Names
melanogenesis associated transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bubalus bubalis Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NDDB_SH_1 Primary Assembly

Genomic

  1. NC_059177.1 Reference NDDB_SH_1 Primary Assembly

    Range
    31544437..31775071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025273061.3 → XP_025128846.1  microphthalmia-associated transcription factor isoform X2

    Conserved Domains (3) summary
    cd00083
    Location:308 → 368
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:396 → 515
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:55 → 193
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  2. XM_025273066.3 → XP_025128851.1  microphthalmia-associated transcription factor isoform X8

    Conserved Domains (3) summary
    cd00083
    Location:253 → 313
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:341 → 460
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56 → 138
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  3. XM_025273060.3 → XP_025128845.1  microphthalmia-associated transcription factor isoform X1

    Conserved Domains (3) summary
    cd00083
    Location:309 → 369
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:397 → 516
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56 → 194
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  4. XM_006055866.4 → XP_006055928.1  microphthalmia-associated transcription factor isoform X4

    See identical proteins and their annotated locations for XP_006055928.1

    Conserved Domains (3) summary
    cd18926
    Location:293 → 396
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:390 → 509
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:55 → 193
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  5. XM_006055871.4 → XP_006055933.1  microphthalmia-associated transcription factor isoform X9

    See identical proteins and their annotated locations for XP_006055933.1

    Related
    ENSBALP00030025189.1, ENSBALT00030037451.1
    Conserved Domains (3) summary
    cd18926
    Location:238 → 341
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:335 → 454
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56 → 138
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  6. XM_006055865.4 → XP_006055927.1  microphthalmia-associated transcription factor isoform X3

    See identical proteins and their annotated locations for XP_006055927.1

    Related
    ENSBALP00030025255.1, ENSBALT00030037539.1
    Conserved Domains (3) summary
    cd18926
    Location:294 → 397
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:391 → 510
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56 → 194
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  7. XM_044933795.2 → XP_044789730.1  microphthalmia-associated transcription factor isoform X7

    Conserved Domains (3) summary
    cd18926
    Location:248 → 351
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:345 → 464
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:4 → 142
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  8. XM_025273062.3 → XP_025128847.1  microphthalmia-associated transcription factor isoform X5

    Conserved Domains (3) summary
    cd00083
    Location:293 → 353
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:381 → 500
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:40 → 178
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  9. XM_006055867.4 → XP_006055929.1  microphthalmia-associated transcription factor isoform X6

    See identical proteins and their annotated locations for XP_006055929.1

    Related
    ENSBALP00030025234.1, ENSBALT00030037510.1
    Conserved Domains (3) summary
    cd18926
    Location:278 → 381
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:375 → 494
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:40 → 178
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  10. XM_044933797.2 → XP_044789732.1  microphthalmia-associated transcription factor isoform X7

    Related
    ENSBALP00030025110.1, ENSBALT00030037346.1
    Conserved Domains (3) summary
    cd18926
    Location:248 → 351
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:345 → 464
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:4 → 142
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
Nucleotide Protein
Heading Accession and Version

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