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PSEN1 presenilin 1 [ Macaca fascicularis (crab-eating macaque) ]

Gene ID: 102138674, updated on 10-Oct-2024

Summary

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Gene symbol
PSEN1
Gene description
presenilin 1
See related
Ensembl:ENSMFAG00000000113
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca fascicularis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
PS1; PS-1; PSNL1
Orthologs
human mouse all
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Genomic context

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See PSEN1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 7 NC_088381.1 (141034859..141118444)
102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 7 NC_052261.1 (132359651..132440883)

Chromosome 7 - NC_088381.1Genomic Context describing neighboring genes Neighboring gene heat shock cognate 71 kDa protein-like Neighboring gene required for meiotic nuclear division protein 1 homolog Neighboring gene RNA binding motif protein 25 Neighboring gene U7 small nuclear RNA Neighboring gene papilin, proteoglycan like sulfated glycoprotein Neighboring gene NUMB endocytic adaptor protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rate of evolution in brain-expressed genes in humans and other primates. Wang HY, et al. PLoS Biol, 2007 Feb. PMID 17194215, Free PMC Article
  2. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin-1
Names
Presenilin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MFA8v1.0

Genomic

  1. NC_088381.1 Reference T2T-MFA8v1.0

    Range
    141034859..141118444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015453975.3 → XP_015309461.1  presenilin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q8HXW5
    UniProtKB/TrEMBL
    A0A2K5TQQ4, A0A8J8XDD5, G7PAT1
    Related
    ENSMFAP00000002400.1
    Conserved Domains (1) summary
    pfam01080
    Location:76 → 457
    Presenilin

  2. XM_005561705.3 → XP_005561762.1  presenilin-1 isoform X1

    See identical proteins and their annotated locations for XP_005561762.1

    UniProtKB/Swiss-Prot
    Q8HXW5
    UniProtKB/TrEMBL
    A0A2K5TQQ4, A0A8J8XDD5, G7PAT1
    Related
    ENSMFAP00000002389.1
    Conserved Domains (1) summary
    pfam01080
    Location:76 → 457
    Presenilin

  3. XM_005561706.4 → XP_005561763.1  presenilin-1 isoform X2

    See identical proteins and their annotated locations for XP_005561763.1

    UniProtKB/Swiss-Prot
    Q8HXW5
    Conserved Domains (1) summary
    pfam01080
    Location:72 → 453
    Presenilin

  4. XM_065549021.1 → XP_065405093.1  presenilin-1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5TQQ4, A0A8J8XDD5, G7PAT1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8HXW5.1 GenPept UniProtKB/Swiss-Prot:Q8HXW5

Gene LinkOut

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