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NUTF2 nuclear transport factor 2 [ Homo sapiens (human) ]

Gene ID: 10204, updated on 2-Nov-2024

Summary

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Official Symbol
NUTF2provided by HGNC
Official Full Name
nuclear transport factor 2provided by HGNC
Primary source
HGNC:HGNC:13722
See related
Ensembl:ENSG00000102898 MIM:605813; AllianceGenome:HGNC:13722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTF2; PP15; NTF-2
Summary
This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in placenta (RPKM 14.8), testis (RPKM 14.7) and 25 other tissues See more
Orthologs
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Genomic context

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See NUTF2 in Genome Data Viewer
Location:
16q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67846933..67872567)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73642707..73668340)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67880836..67906470)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67840207-67840826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7626 Neighboring gene translin associated factor X interacting protein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67851021-67851203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67859393-67860253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10987 Neighboring gene centromere protein T Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67876439-67877185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10991 Neighboring gene THAP domain containing 11 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67907171-67907671 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918365-67918874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918875-67919382 Neighboring gene neuritin 1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins.
    Title: DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins.
  2. Nuclear Transport Factor 2 (NTF2) suppresses WM983B metastatic melanoma by modifying cell migration, metastasis, and gene expression.
    Title: Nuclear Transport Factor 2 (NTF2) suppresses WM983B metastatic melanoma by modifying cell migration, metastasis, and gene expression.
  3. These results showed that BLM enters the nucleus via the importin beta1, RanGDP and NTF2 dependent pathway, demonstrating for the first time the nuclear trafficking mechanism of a DNA helicase.
    Title: Characterization of the nuclear import pathway for BLM protein.
  4. Binding of Ran to NTF2 is required for NTF2 to inhibit nuclear expansion and import of large cargo molecules.
    Title: Nuclear size is sensitive to NTF2 protein levels in a manner dependent on Ran binding.
  5. Nucleocytoplasmic translocation of NTF2 is regulated in mammalian cells.
    Title: Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation.
  6. Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation, resulting in decreased actin export via Exp6 inactivation.
    Title: Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells.
  7. NTF2 is a potential mediator of retinal vasculature integrity.
    Title: Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy.
  8. Results report that NTF2 and Ran control nuclear import of the filamentous actin capping protein CapG.
    Title: A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.
  9. A nuclear pore binding site was studied on a mutated NTF2 protein.
    Title: Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Common variants at 30 loci contribute to polygenic dyslipidemia.
EBI GWAS Catalog
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol NTF2 is enriched at the nuclear envelope and interacts with NUP153, When added in excess to the import assay, NUP153C inhibited the nuclear import of IN. PubMed
matrix gag NTF2 coordinates the activity of Ran by binding Ran-GDP into a complex with nucleoporin-docked karyopherins during nuclear import of HIV-1 Matrix PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear transport factor 2
Names
placental protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322038.2 → NP_001308967.1  nuclear transport factor 2

    Status: REVIEWED

    Source sequence(s)
    AC040162
    Consensus CDS
    CCDS10848.1
    UniProtKB/Swiss-Prot
    B2R4G7, P13662, P61970, Q6IB67
    UniProtKB/TrEMBL
    H3BRV9
    Related
    ENSP00000515103.1, ENST00000700613.1
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  2. NM_001322039.2 → NP_001308968.1  nuclear transport factor 2

    Status: REVIEWED

    Source sequence(s)
    AC040162, BP216441
    Consensus CDS
    CCDS10848.1
    UniProtKB/Swiss-Prot
    B2R4G7, P13662, P61970, Q6IB67
    UniProtKB/TrEMBL
    H3BRV9
    Related
    ENSP00000456428.1, ENST00000567105.5
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  3. NM_001322040.2 → NP_001308969.1  nuclear transport factor 2

    Status: REVIEWED

    Source sequence(s)
    BX647782, HY123109, X07315
    Consensus CDS
    CCDS10848.1
    UniProtKB/Swiss-Prot
    B2R4G7, P13662, P61970, Q6IB67
    UniProtKB/TrEMBL
    H3BRV9
    Related
    ENSP00000457989.1, ENST00000569436.7
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  4. NM_001322041.2 → NP_001308970.1  nuclear transport factor 2

    Status: REVIEWED

    Source sequence(s)
    AC040162, BX394845
    Consensus CDS
    CCDS10848.1
    UniProtKB/Swiss-Prot
    B2R4G7, P13662, P61970, Q6IB67
    UniProtKB/TrEMBL
    H3BRV9
    Related
    ENSP00000457022.1, ENST00000568396.2
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  5. NM_005796.3 → NP_005787.1  nuclear transport factor 2

    See identical proteins and their annotated locations for NP_005787.1

    Status: REVIEWED

    Source sequence(s)
    BX647782, X07315
    Consensus CDS
    CCDS10848.1
    UniProtKB/Swiss-Prot
    B2R4G7, P13662, P61970, Q6IB67
    UniProtKB/TrEMBL
    H3BRV9
    Related
    ENSP00000219169.4, ENST00000219169.9
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67846933..67872567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    73642707..73668340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61970.1 GenPept UniProtKB/Swiss-Prot:P61970

Gene LinkOut

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Chemical Information
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