TNK2 tyrosine kinase non receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNK2provided by HGNC
Official Full Name: tyrosine kinase non receptor 2provided by HGNC
Primary source: HGNC:HGNC:19297
See related: Ensembl:ENSG00000061938 MIM:606994; AllianceGenome:HGNC:19297
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ACK; ACK1; ACK-1; p21cdc42Hs
Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q29

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (195863364..195908551, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (198449491..198494501)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (195590235..195635422, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.
Title: ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.
Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.
Title: Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.
Host factor TNK2 is required for influenza virus infection.
Title: Host factor TNK2 is required for influenza virus infection.
ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
Title: ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
Title: Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.
Title: Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.
Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.
Title: Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.
Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.
Title: Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.
Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition.
Title: Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition.
TNK2 promoted esophageal cancer progression via activating egfr-akt signaling.
Title: TNK2 promoted esophageal cancer progression via activating egfr-akt signaling.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

D8S2282 (e-PCR)
- UniSTS:473910

ksks337 (e-PCR)
- UniSTS:514383

D10S16 (e-PCR)
- UniSTS:155756

STS-R44803 (e-PCR)
- UniSTS:10961

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables GTPase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables WW domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of clathrin-dependent endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in small GTPase-mediated signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of Grb2-EGFR complex	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoophidium	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: activated CDC42 kinase 1

Names: activated Cdc42-associated kinase 1; activated p21cdc42Hs kinase; tyrosine kinase non-receptor protein 2

NP_001010938.2

EC 2.7.10.2

EC 2.7.11.1

NP_001294975.1

EC 2.7.10.2

EC 2.7.11.1

NP_001369200.1

EC 2.7.10.2

EC 2.7.11.1

NP_001369201.1

EC 2.7.10.2

EC 2.7.11.1

NP_001369202.1

EC 2.7.10.2

EC 2.7.11.1

NP_001369203.1

EC 2.7.10.2

EC 2.7.11.1

NP_001369204.1

EC 2.7.10.2

EC 2.7.11.1

NP_001373093.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374636.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374637.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374638.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374639.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374640.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374641.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374642.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374643.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374644.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374645.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374646.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374647.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374648.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374649.1

EC 2.7.10.2

EC 2.7.11.1

NP_001374650.1

EC 2.7.10.2

EC 2.7.11.1

NP_005772.3

EC 2.7.10.2

EC 2.7.11.1

XP_011510619.2

EC 2.7.10.2

EC 2.7.11.1

XP_011510620.2

EC 2.7.10.2

EC 2.7.11.1

XP_011510623.1

EC 2.7.10.2

EC 2.7.11.1

XP_016860998.1

EC 2.7.10.2

EC 2.7.11.1

XP_024309059.2

EC 2.7.10.2

EC 2.7.11.1

XP_024309060.1

EC 2.7.10.2

EC 2.7.11.1

XP_024309061.1

EC 2.7.10.2

EC 2.7.11.1

XP_024309063.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303097.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303098.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303099.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303100.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303101.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303102.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303103.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303104.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303105.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303106.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303107.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303108.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303109.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303110.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303111.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303112.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303113.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303114.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303115.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303116.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303117.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303118.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303119.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303120.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303121.1

EC 2.7.10.2

EC 2.7.11.1

XP_047303122.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200826.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200827.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200828.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200829.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200830.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200831.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200832.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200833.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200834.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200835.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200836.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200837.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200838.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200839.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200840.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200841.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200842.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200843.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200844.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200845.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200846.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200847.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200848.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200849.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200850.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200851.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200852.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200853.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200854.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200855.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200856.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200857.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200858.1

EC 2.7.10.2

EC 2.7.11.1

XP_054200859.1

EC 2.7.10.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029779.1 RefSeqGene

Range

5459..50646

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001010938.2 → NP_001010938.2 activated CDC42 kinase 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has a distinct 5' UTR and 5' coding region, lacks one alternate 3' coding exon, and contains a different alternate 3' coding exon, as compared to variant 1. The translation remains in-frame, and results in a longer isoform (2) that has a longer and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK127455, AK131539, BC020395, L13738

Consensus CDS

CCDS33927.2

UniProtKB/TrEMBL

A0A499FJ16

Related

ENSP00000499858.1, ENST00000671753.1

Conserved Domains (7) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:582 → 888

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:998 → 1037

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:473 → 538

GTPase_binding; GTPase binding

pfam11555
Location:813 → 879

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain
NM_001308046.2 → NP_001294975.1 activated CDC42 kinase 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate 5' exon, contains an alternate 5' terminal exon, lacks one alternate 3' coding exon, and initiates translation at an alternate start codon, compared to variant 1. It encodes a shorter isoform (3) that has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC124944

Consensus CDS

CCDS77875.1

UniProtKB/TrEMBL

A0A499FJ16, C9J1X3

Related

ENSP00000392546.1, ENST00000428187.7

Conserved Domains (7) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

smart00221
Location:158 → 417

STYKc; Protein kinase; unclassified specificity

cd14328
Location:991 → 1030

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:479 → 546

GTPase_binding; GTPase binding

pfam11555
Location:806 → 870

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
NM_001382271.1 → NP_001369200.1 activated CDC42 kinase 1 isoform 4

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS93443.1

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZHJ2

Related

ENSP00000503221.1, ENST00000678220.1

Conserved Domains (8) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:575 → 881

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:993 → 1036

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1023 → 1062

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:481 → 546

GTPase_binding; GTPase binding

pfam11555
Location:806 → 870

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
NM_001382272.1 → NP_001369201.1 activated CDC42 kinase 1 isoform 5

Status: REVIEWED

Source sequence(s)

AC124944

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (8) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:582 → 888

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:1000 → 1043

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1030 → 1069

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:473 → 538

GTPase_binding; GTPase binding

pfam11555
Location:813 → 877

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain
NM_001382273.1 → NP_001369202.1 activated CDC42 kinase 1 isoform 6

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS93442.1

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZGX5

Related

ENSP00000499899.1, ENST00000672887.2

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:558 → 864

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:976 → 1019

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1006 → 1045

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:789 → 853

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001382274.1 → NP_001369203.1 activated CDC42 kinase 1 isoform 6

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS93442.1

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZGX5

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:558 → 864

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:976 → 1019

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1006 → 1045

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:789 → 853

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001382275.1 → NP_001369204.1 activated CDC42 kinase 1 isoform 7

Status: REVIEWED

Source sequence(s)

AC124944

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (7) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:590 → 896

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:1006 → 1045

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:481 → 546

GTPase_binding; GTPase binding

pfam11555
Location:821 → 885

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
NM_001386164.1 → NP_001373093.1 activated CDC42 kinase 1 isoform 8

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS93441.1

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZI29

Related

ENSP00000500887.1, ENST00000673420.1

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:543 → 849

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:961 → 1004

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:991 → 1030

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387707.1 → NP_001374636.1 activated CDC42 kinase 1 isoform 9

Status: REVIEWED

Source sequence(s)

AC124944

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (8) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:590 → 896

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:1008 → 1051

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1038 → 1077

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:481 → 546

GTPase_binding; GTPase binding

pfam11555
Location:821 → 885

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
NM_001387708.1 → NP_001374637.1 activated CDC42 kinase 1 isoform 10

Status: REVIEWED

Source sequence(s)

AC124944

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (8) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:567 → 873

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:985 → 1028

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1015 → 1054

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:473 → 538

GTPase_binding; GTPase binding

pfam11555
Location:798 → 862

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain
NM_001387709.1 → NP_001374638.1 activated CDC42 kinase 1 isoform 8

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS93441.1

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZI29

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:543 → 849

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:961 → 1004

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:991 → 1030

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387710.1 → NP_001374639.1 activated CDC42 kinase 1 isoform 8

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS93441.1

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZI29

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:543 → 849

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:961 → 1004

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:991 → 1030

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387711.1 → NP_001374640.1 activated CDC42 kinase 1 isoform 8

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS93441.1

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZI29

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:543 → 849

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:961 → 1004

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:991 → 1030

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387712.1 → NP_001374641.1 activated CDC42 kinase 1 isoform 8

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS93441.1

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZI29

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:543 → 849

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:961 → 1004

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:991 → 1030

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387713.1 → NP_001374642.1 activated CDC42 kinase 1 isoform 1

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS33928.1

UniProtKB/Swiss-Prot

Q07912, Q6ZMQ0, Q8N6U7, Q96H59

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:543 → 849

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:958 → 1002

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:989 → 1028

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387714.1 → NP_001374643.1 activated CDC42 kinase 1 isoform 1

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS33928.1

UniProtKB/Swiss-Prot

Q07912, Q6ZMQ0, Q8N6U7, Q96H59

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:543 → 849

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:958 → 1002

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:989 → 1028

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387715.1 → NP_001374644.1 activated CDC42 kinase 1 isoform 11

Status: REVIEWED

Source sequence(s)

AC124944

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (7) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:567 → 873

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:983 → 1022

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:473 → 538

GTPase_binding; GTPase binding

pfam11555
Location:798 → 862

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain
NM_001387716.1 → NP_001374645.1 activated CDC42 kinase 1 isoform 12

Status: REVIEWED

Source sequence(s)

AC124944

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (7) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:558 → 864

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:974 → 1013

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:789 → 853

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387717.1 → NP_001374646.1 activated CDC42 kinase 1 isoform 12

Status: REVIEWED

Source sequence(s)

AC124944

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (7) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:558 → 864

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:974 → 1013

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:789 → 853

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387718.1 → NP_001374647.1 activated CDC42 kinase 1 isoform 12

Status: REVIEWED

Source sequence(s)

AC124944

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (7) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:558 → 864

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:974 → 1013

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:789 → 853

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387719.1 → NP_001374648.1 activated CDC42 kinase 1 isoform 13

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS93440.1

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZHP4

Conserved Domains (7) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:543 → 849

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:959 → 998

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387720.1 → NP_001374649.1 activated CDC42 kinase 1 isoform 13

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS93440.1

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZHP4

Related

ENSP00000500486.1, ENST00000672024.1

Conserved Domains (7) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:543 → 849

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:959 → 998

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_001387721.1 → NP_001374650.1 activated CDC42 kinase 1 isoform 13

Status: REVIEWED

Source sequence(s)

AC124944

Consensus CDS

CCDS93440.1

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZHP4

Conserved Domains (7) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:543 → 849

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:959 → 998

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
NM_005781.5 → NP_005772.3 activated CDC42 kinase 1 isoform 1

See identical proteins and their annotated locations for NP_005772.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the more frequently occurring transcript and it encodes isoform 1.

Source sequence(s)

AC124944, AK127455, AK131539, BG742978, CN411136, L13738

Consensus CDS

CCDS33928.1

UniProtKB/Swiss-Prot

Q07912, Q6ZMQ0, Q8N6U7, Q96H59

UniProtKB/TrEMBL

A0A499FJ16

Related

ENSP00000329425.6, ENST00000333602.14

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:543 → 849

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:958 → 1002

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:989 → 1028

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:774 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain

RNA

NR_170678.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170679.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170680.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170681.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170682.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170683.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170684.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170685.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170686.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170687.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170688.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170689.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170690.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170691.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944
NR_170692.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124944

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

195863364..195908551 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047447154.1 → XP_047303110.1 activated CDC42 kinase 1 isoform X15
XM_047447157.1 → XP_047303113.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

A0A5F9ZGX5
XM_047447153.1 → XP_047303109.1 activated CDC42 kinase 1 isoform X5

UniProtKB/TrEMBL

A0A5F9ZHJ2
XM_047447161.1 → XP_047303117.1 activated CDC42 kinase 1 isoform X19
XM_047447143.1 → XP_047303099.1 activated CDC42 kinase 1 isoform X1
XM_047447142.1 → XP_047303098.1 activated CDC42 kinase 1 isoform X1
XM_047447162.1 → XP_047303118.1 activated CDC42 kinase 1 isoform X20
XM_047447156.1 → XP_047303112.1 activated CDC42 kinase 1 isoform X17
XM_024453292.2 → XP_024309060.1 activated CDC42 kinase 1 isoform X14

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (6) summary

cd09539
Location:23 → 84

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

smart00326
Location:410 → 461

SH3; Src homology 3 domains

PHA03247
Location:575 → 881

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:993 → 1036

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1023 → 1062

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:147 → 404

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
XM_047447150.1 → XP_047303106.1 activated CDC42 kinase 1 isoform X11
XM_047447160.1 → XP_047303116.1 activated CDC42 kinase 1 isoform X13

UniProtKB/Swiss-Prot

Q07912, Q6ZMQ0, Q8N6U7, Q96H59
XM_047447159.1 → XP_047303115.1 activated CDC42 kinase 1 isoform X18

UniProtKB/TrEMBL

A0A5F9ZI29
XM_047447158.1 → XP_047303114.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

A0A5F9ZGX5
XM_024453295.2 → XP_024309063.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZGX5

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:558 → 864

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:976 → 1019

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1006 → 1045

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:789 → 853

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
XM_047447141.1 → XP_047303097.1 activated CDC42 kinase 1 isoform X1
XM_047447151.1 → XP_047303107.1 activated CDC42 kinase 1 isoform X13

UniProtKB/Swiss-Prot

Q07912, Q6ZMQ0, Q8N6U7, Q96H59
XM_024453291.2 → XP_024309059.2 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

A0A5F9ZGX5
XM_047447148.1 → XP_047303104.1 activated CDC42 kinase 1 isoform X9

UniProtKB/TrEMBL

C9J1X3
XM_047447146.1 → XP_047303102.1 activated CDC42 kinase 1 isoform X6
XM_047447145.1 → XP_047303101.1 activated CDC42 kinase 1 isoform X5

UniProtKB/TrEMBL

A0A5F9ZHJ2
XM_047447147.1 → XP_047303103.1 activated CDC42 kinase 1 isoform X8
XM_011512318.3 → XP_011510620.2 activated CDC42 kinase 1 isoform X4

UniProtKB/TrEMBL

A0A499FJ16
XM_011512317.4 → XP_011510619.2 activated CDC42 kinase 1 isoform X2
XM_047447152.1 → XP_047303108.1 activated CDC42 kinase 1 isoform X5

UniProtKB/TrEMBL

A0A5F9ZHJ2
XM_024453293.2 → XP_024309061.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

A0A499FJ16, A0A5F9ZGX5

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:558 → 864

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:976 → 1019

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1006 → 1045

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:449 → 514

GTPase_binding; GTPase binding

pfam11555
Location:789 → 853

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain
XM_047447155.1 → XP_047303111.1 activated CDC42 kinase 1 isoform X16
XM_047447163.1 → XP_047303119.1 activated CDC42 kinase 1 isoform X22
XM_011512321.2 → XP_011510623.1 activated CDC42 kinase 1 isoform X21

UniProtKB/TrEMBL

A0A499FJ16

Conserved Domains (7) summary

smart00221
Location:50 → 309

STYKc; Protein kinase; unclassified specificity

cd14274
Location:900 → 943

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:930 → 969

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:54 → 311

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:371 → 438

GTPase_binding; GTPase binding

pfam11555
Location:713 → 777

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:319 → 368

SH3_9; Variant SH3 domain
XM_047447164.1 → XP_047303120.1 activated CDC42 kinase 1 isoform X23
XM_047447165.1 → XP_047303121.1 activated CDC42 kinase 1 isoform X23
XM_047447166.1 → XP_047303122.1 activated CDC42 kinase 1 isoform X24

UniProtKB/TrEMBL

B3KXJ4

Related

ENSP00000500238.1, ENST00000672548.1
XM_047447149.1 → XP_047303105.1 activated CDC42 kinase 1 isoform X10
XM_017005509.2 → XP_016860998.1 activated CDC42 kinase 1 isoform X7

UniProtKB/TrEMBL

A0A499FJ16
XM_047447144.1 → XP_047303100.1 activated CDC42 kinase 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

198449491..198494501

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054344851.1 → XP_054200826.1 activated CDC42 kinase 1 isoform X1
XM_054344852.1 → XP_054200827.1 activated CDC42 kinase 1 isoform X1
XM_054344877.1 → XP_054200852.1 activated CDC42 kinase 1 isoform X19
XM_054344867.1 → XP_054200842.1 activated CDC42 kinase 1 isoform X5

UniProtKB/TrEMBL

A0A5F9ZHJ2
XM_054344872.1 → XP_054200847.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

A0A5F9ZGX5
XM_054344862.1 → XP_054200837.1 activated CDC42 kinase 1 isoform X11
XM_054344865.1 → XP_054200840.1 activated CDC42 kinase 1 isoform X14
XM_054344869.1 → XP_054200844.1 activated CDC42 kinase 1 isoform X17
XM_054344878.1 → XP_054200853.1 activated CDC42 kinase 1 isoform X20
XM_054344875.1 → XP_054200850.1 activated CDC42 kinase 1 isoform X18

UniProtKB/TrEMBL

A0A5F9ZI29
XM_054344876.1 → XP_054200851.1 activated CDC42 kinase 1 isoform X13

UniProtKB/Swiss-Prot

Q07912, Q6ZMQ0, Q8N6U7, Q96H59
XM_054344873.1 → XP_054200848.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

A0A5F9ZGX5
XM_054344874.1 → XP_054200849.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

A0A5F9ZGX5
XM_054344871.1 → XP_054200846.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

A0A5F9ZGX5
XM_054344855.1 → XP_054200830.1 activated CDC42 kinase 1 isoform X4
XM_054344859.1 → XP_054200834.1 activated CDC42 kinase 1 isoform X8
XM_054344856.1 → XP_054200831.1 activated CDC42 kinase 1 isoform X5

UniProtKB/TrEMBL

A0A5F9ZHJ2
XM_054344857.1 → XP_054200832.1 activated CDC42 kinase 1 isoform X6
XM_054344860.1 → XP_054200835.1 activated CDC42 kinase 1 isoform X9

UniProtKB/TrEMBL

C9J1X3
XM_054344863.1 → XP_054200838.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

A0A5F9ZGX5
XM_054344864.1 → XP_054200839.1 activated CDC42 kinase 1 isoform X13

UniProtKB/Swiss-Prot

Q07912, Q6ZMQ0, Q8N6U7, Q96H59
XM_054344854.1 → XP_054200829.1 activated CDC42 kinase 1 isoform X3
XM_054344858.1 → XP_054200833.1 activated CDC42 kinase 1 isoform X7
XM_054344861.1 → XP_054200836.1 activated CDC42 kinase 1 isoform X10
XM_054344866.1 → XP_054200841.1 activated CDC42 kinase 1 isoform X5

UniProtKB/TrEMBL

A0A5F9ZHJ2
XM_054344853.1 → XP_054200828.1 activated CDC42 kinase 1 isoform X2
XM_054344870.1 → XP_054200845.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

A0A5F9ZGX5
XM_054344868.1 → XP_054200843.1 activated CDC42 kinase 1 isoform X16
XM_054344879.1 → XP_054200854.1 activated CDC42 kinase 1 isoform X21
XM_054344880.1 → XP_054200855.1 activated CDC42 kinase 1 isoform X22
XM_054344881.1 → XP_054200856.1 activated CDC42 kinase 1 isoform X23
XM_054344882.1 → XP_054200857.1 activated CDC42 kinase 1 isoform X23
XM_054344883.1 → XP_054200858.1 activated CDC42 kinase 1 isoform X24

UniProtKB/TrEMBL

B3KXJ4
XM_054344884.1 → XP_054200859.1 activated CDC42 kinase 1 isoform X24

UniProtKB/TrEMBL

B3KXJ4