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Wfikkn1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101726657, updated on 8-Mar-2024

Summary

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Gene symbol
Wfikkn1
Gene description
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Locus tag
GW7_12982
See related
Ensembl:ENSHGLG00000005937
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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See Wfikkn1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
2
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624913.1 (1442351..1446249)

NW_004624913.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class Q Neighboring gene RAB40C, member RAS oncogene family Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene methyltransferase like 26

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624913 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
Names
WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624913.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    1442351..1446249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004873792.3 → XP_004873849.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1

    See identical proteins and their annotated locations for XP_004873849.1

    Related
    ENSHGLP00000008206.1, ENSHGLT00000008295.1
    Conserved Domains (6) summary
    smart00131
    Location:361 → 413
    KU; BPTI/Kunitz family of serine protease inhibitors
    cd00104
    Location:124 → 159
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:196 → 284
    I-set; Immunoglobulin I-set domain
    pfam00095
    Location:34 → 80
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    cl02512
    Location:431 → 541
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    cl11960
    Location:204 → 284
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version

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