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LOC101721757 metastasis-associated protein MTA1 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101721757, updated on 25-Jan-2024

Summary

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Gene symbol
LOC101721757
Gene description
metastasis-associated protein MTA1
See related
Ensembl:ENSHGLG00000014183
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Also known as
Mta1
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Genomic context

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See LOC101721757 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
26
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624734.1 (69203..124988, complement)

NW_004624734.1Genomic Context describing neighboring genes Neighboring gene cysteine rich protein 1 Neighboring gene cysteine rich protein 2 Neighboring gene stathmin-2-like Neighboring gene uncharacterized LOC110345581 Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene proteasome subunit alpha type-6-like Neighboring gene BRF1 general transcription factor IIIB subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624734 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NuRD complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
metastasis-associated protein MTA1
Names
metastasis associated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624734.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    69203..124988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021243340.1 → XP_021098999.1  metastasis-associated protein MTA1 isoform X8

    UniProtKB/TrEMBL
    G5AWK0
    Conserved Domains (4) summary
    cd11661
    Location:351 → 396
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:452 → 505
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:89 → 252
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:231 → 283
    ELM2; ELM2 domain

  2. XM_021243328.1 → XP_021098987.1  metastasis-associated protein MTA1 isoform X5

    UniProtKB/TrEMBL
    G5AWK0
    Conserved Domains (4) summary
    cd11661
    Location:368 → 413
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:469 → 522
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:89 → 269
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:248 → 300
    ELM2; ELM2 domain

  3. XM_013066090.2 → XP_012921544.1  metastasis-associated protein MTA1 isoform X5

    UniProtKB/TrEMBL
    G5AWK0
    Conserved Domains (4) summary
    cd11661
    Location:368 → 413
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:469 → 522
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:89 → 269
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:248 → 300
    ELM2; ELM2 domain

  4. XM_021243353.1 → XP_021099012.1  metastasis-associated protein MTA1 isoform X10

    UniProtKB/TrEMBL
    G5AWK0
    Related
    ENSHGLP00000019816.1, ENSHGLT00000020014.1
    Conserved Domains (4) summary
    cd11661
    Location:270 → 315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:371 → 424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3 → 171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150 → 202
    ELM2; ELM2 domain

  5. XM_013066102.2 → XP_012921556.1  metastasis-associated protein MTA1 isoform X9

    UniProtKB/TrEMBL
    G5AWK0
    Related
    ENSHGLP00000019814.1, ENSHGLT00000020012.1
    Conserved Domains (6) summary
    smart00717
    Location:286 → 333
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:287 → 332
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:388 → 441
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:392 → 448
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3 → 188
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:167 → 219
    ELM2; ELM2 domain

  6. XM_021243337.1 → XP_021098996.1  metastasis-associated protein MTA1 isoform X7

    UniProtKB/TrEMBL
    G5AWK0
    Conserved Domains (4) summary
    cd11661
    Location:269 → 314
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:370 → 423
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:9 → 170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:149 → 201
    ELM2; ELM2 domain

  7. XM_021243335.1 → XP_021098994.1  metastasis-associated protein MTA1 isoform X6

    UniProtKB/TrEMBL
    G5AWK0
    Conserved Domains (4) summary
    cd11661
    Location:269 → 314
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:370 → 423
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:9 → 170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:149 → 201
    ELM2; ELM2 domain

  8. XM_021243326.1 → XP_021098985.1  metastasis-associated protein MTA1 isoform X4

    UniProtKB/TrEMBL
    G5AWK0
    Conserved Domains (4) summary
    cd11661
    Location:269 → 314
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:370 → 423
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:9 → 170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:149 → 201
    ELM2; ELM2 domain

  9. XM_021243325.1 → XP_021098984.1  metastasis-associated protein MTA1 isoform X3

    UniProtKB/TrEMBL
    G5AWK0
    Related
    ENSHGLP00000019815.1, ENSHGLT00000020013.1
    Conserved Domains (4) summary
    cd11661
    Location:286 → 331
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:387 → 440
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:9 → 187
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:166 → 218
    ELM2; ELM2 domain

  10. XM_021243324.1 → XP_021098983.1  metastasis-associated protein MTA1 isoform X2

    UniProtKB/TrEMBL
    G5AWK0
    Related
    ENSHGLP00000019818.1, ENSHGLT00000020016.1
    Conserved Domains (4) summary
    cd11661
    Location:286 → 331
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:387 → 440
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:9 → 187
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:166 → 218
    ELM2; ELM2 domain

  11. XM_021243323.1 → XP_021098982.1  metastasis-associated protein MTA1 isoform X1

    UniProtKB/TrEMBL
    G5AWK0
    Conserved Domains (4) summary
    cd11661
    Location:286 → 331
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:387 → 440
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:9 → 187
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:166 → 218
    ELM2; ELM2 domain

  12. XM_021243361.1 → XP_021099020.1  metastasis-associated protein MTA1 isoform X11

    Conserved Domains (3) summary
    cd11661
    Location:286 → 331
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    cd04709
    Location:9 → 187
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:166 → 218
    ELM2; ELM2 domain

RNA

  1. XR_002388994.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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