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Dlg4 discs large MAGUK scaffold protein 4 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101708587, updated on 8-Mar-2024

Summary

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Gene symbol
Dlg4
Gene description
discs large MAGUK scaffold protein 4
Locus tag
GW7_13803
See related
Ensembl:ENSHGLG00000010073
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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See Dlg4 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624786.1 (9811201..9835660, complement)

NW_004624786.1Genomic Context describing neighboring genes Neighboring gene asialoglycoprotein receptor 2 Neighboring gene rho-related GTP-binding protein RhoQ pseudogene Neighboring gene asialoglycoprotein receptor 1 Neighboring gene acyl-CoA dehydrogenase very long chain Neighboring gene dishevelled segment polarity protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624786 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in AMPA glutamate receptor clustering IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor diffusion trapping IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disks large homolog 4
Names
Disks large-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624786.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    9811201..9835660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021238492.1 → XP_021094151.1  disks large homolog 4 isoform X3

    Conserved Domains (6) summary
    cd12030
    Location:463 → 528
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:343 → 427
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:98 → 182
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:566 → 744
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:278 → 345
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:10 → 97
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  2. XM_013076820.2 → XP_012932274.1  disks large homolog 4 isoform X9

    See identical proteins and their annotated locations for XP_012932274.1

    Conserved Domains (6) summary
    cd12030
    Location:405 → 470
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:285 → 369
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:40 → 124
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:508 → 686
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:220 → 287
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:7 → 39
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  3. XM_013076818.2 → XP_012932272.1  disks large homolog 4 isoform X8

    See identical proteins and their annotated locations for XP_012932272.1

    Conserved Domains (6) summary
    cd12030
    Location:408 → 473
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:288 → 372
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:43 → 127
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:511 → 689
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:223 → 290
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:7 → 42
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  4. XM_004857373.2 → XP_004857430.1  disks large homolog 4 isoform X7

    See identical proteins and their annotated locations for XP_004857430.1

    UniProtKB/TrEMBL
    G5B5A1
    Conserved Domains (6) summary
    cd12030
    Location:427 → 492
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:307 → 391
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:62 → 146
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:530 → 708
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:242 → 309
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:10 → 61
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  5. XM_013076817.2 → XP_012932271.1  disks large homolog 4 isoform X6

    See identical proteins and their annotated locations for XP_012932271.1

    Related
    ENSHGLP00000014107.1, ENSHGLT00000014250.1
    Conserved Domains (6) summary
    cd12030
    Location:430 → 495
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:310 → 394
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:65 → 149
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:533 → 711
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245 → 312
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:10 → 64
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  6. XM_021238494.1 → XP_021094153.1  disks large homolog 4 isoform X5

    Conserved Domains (6) summary
    cd12030
    Location:422 → 487
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:302 → 386
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:57 → 141
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:525 → 703
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:237 → 304
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:6 → 56
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  7. XM_021238493.1 → XP_021094152.1  disks large homolog 4 isoform X4

    Related
    ENSHGLP00000014108.1, ENSHGLT00000014251.1
    Conserved Domains (6) summary
    cd12030
    Location:425 → 490
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:305 → 389
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:60 → 144
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:528 → 706
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:240 → 307
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:6 → 59
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  8. XM_021238491.1 → XP_021094150.1  disks large homolog 4 isoform X2

    Conserved Domains (6) summary
    cd12030
    Location:458 → 523
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:338 → 422
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:93 → 177
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:561 → 739
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:273 → 340
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:6 → 92
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  9. XM_013076821.2 → XP_012932275.1  disks large homolog 4 isoform X10

    See identical proteins and their annotated locations for XP_012932275.1

    Conserved Domains (6) summary
    cd12030
    Location:356 → 421
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00072
    Location:470 → 636
    GuKc; Guanylate kinase homologues
    smart00228
    Location:236 → 320
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:86 → 170
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:459 → 637
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:171 → 238
    PDZ_assoc; PDZ-associated domain of NMDA receptors

  10. XM_021238490.1 → XP_021094149.1  disks large homolog 4 isoform X1

    Conserved Domains (5) summary
    cd12030
    Location:370 → 435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:250 → 334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:5 → 89
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473 → 651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185 → 252
    PDZ_assoc; PDZ-associated domain of NMDA receptors

  11. XM_021238495.1 → XP_021094154.1  disks large homolog 4 isoform X1

    Conserved Domains (5) summary
    cd12030
    Location:370 → 435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:250 → 334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:5 → 89
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473 → 651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185 → 252
    PDZ_assoc; PDZ-associated domain of NMDA receptors

  12. XM_021238496.1 → XP_021094155.1  disks large homolog 4 isoform X1

    Conserved Domains (5) summary
    cd12030
    Location:370 → 435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:250 → 334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:5 → 89
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473 → 651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185 → 252
    PDZ_assoc; PDZ-associated domain of NMDA receptors
Nucleotide Protein
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