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Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101707403, updated on 8-Mar-2024

Summary

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Gene symbol
Mthfd1
Gene description
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
See related
Ensembl:ENSHGLG00000009911
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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See Mthfd1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
30
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624734.1 (36560486..36620043, complement)

NW_004624734.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene A-kinase anchoring protein 5 Neighboring gene coiled-coil domain-containing protein 170-like Neighboring gene integrator complex subunit 10-like Neighboring gene zinc finger protein 124 pseudogene Neighboring gene small nuclear ribonucleoprotein G pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624734 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables formate-tetrahydrofolate ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methenyltetrahydrofolate cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
C-1-tetrahydrofolate synthase, cytoplasmic

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624734.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    36560486..36620043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004837414.3 → XP_004837471.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X3

    UniProtKB/TrEMBL
    A0A0P6K8T9, G5BD00
    Related
    ENSHGLP00000013868.1, ENSHGLT00000014009.1
    Conserved Domains (4) summary
    cd01080
    Location:120 → 292
    NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:310 → 935
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 297
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:6 → 125
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

  2. XM_013067731.2 → XP_012923185.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    G5BD00
    Conserved Domains (4) summary
    cd01080
    Location:146 → 318
    NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:336 → 961
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:40 → 323
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:40 → 151
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

  3. XM_004837413.2 → XP_004837470.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    G5BD00
    Conserved Domains (4) summary
    cd01080
    Location:137 → 309
    NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:327 → 952
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:31 → 314
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:29 → 142
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Nucleotide Protein
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