Zfp575 zinc finger protein 575 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp575provided by MGI
Official Full Name: zinc finger protein 575provided by MGI
Primary source: MGI:MGI:2141921
See related: Ensembl:ENSMUSG00000066721 AllianceGenome:MGI:2141921
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znf575
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF575 (zinc finger protein 575). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 2.3), whole brain E14.5 (RPKM 2.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 11.63 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24283942..24287049, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (24583838..24587840, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The zinc figure protein ZNF575 impairs colorectal cancer growth via promoting p53 transcription.
Title: The zinc figure protein ZNF575 impairs colorectal cancer growth via promoting p53 transcription.

Submit: New GeneRIF Correction

General gene information

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Markers

px-50g7 (e-PCR)
- UniSTS:257891

AI326876 (e-PCR)
- UniSTS:165514

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 575

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033205.4 → NP_001028377.1 zinc finger protein 575

See identical proteins and their annotated locations for NP_001028377.1

Status: VALIDATED

Source sequence(s)

AC161166

Consensus CDS

CCDS20956.1

UniProtKB/Swiss-Prot

Q3TXZ1

UniProtKB/TrEMBL

B2RX29

Related

ENSMUSP00000092294.3, ENSMUST00000094705.3

Conserved Domains (1) summary

sd00017
Location:87 → 107

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001419146.1 → NP_001406075.1 zinc finger protein 575

Status: VALIDATED

Source sequence(s)

AC161166

UniProtKB/Swiss-Prot

Q3TXZ1

UniProtKB/TrEMBL

B2RX29