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ITGB4 integrin subunit beta 4 [ Ovis aries (sheep) ]

Gene ID: 101119919, updated on 8-Mar-2024

Summary

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Gene symbol
ITGB4
Gene description
integrin subunit beta 4
See related
EnsemblRapid:ENSOARG00020009797
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See ITGB4 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 11 NC_056064.1 (55183226..55215720, complement)

Chromosome 11 - NC_056064.1Genomic Context describing neighboring genes Neighboring gene histone H3.3A Neighboring gene translation machinery-associated protein 7-like Neighboring gene galactokinase 1 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene SAP30 binding protein Neighboring gene uncharacterized LOC121820660 Neighboring gene RecQ like helicase 5 Neighboring gene small integral membrane protein 6 Neighboring gene small integral membrane protein 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056064.1 Chromosome 11 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Combining GWAS and RNA-Seq Approaches for Detection of the Causal Mutation for Hereditary Junctional Epidermolysis Bullosa in Sheep. Suárez-Vega A, et al. PLoS One, 2015. PMID 25955497, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemidesmosome assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin beta-4
Names
integrin, beta 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056064.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    55183226..55215720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027974087.3 → XP_027829888.1  integrin beta-4 isoform X4

    UniProtKB/TrEMBL
    A0A0R7F1J7

  2. XM_027974086.3 → XP_027829887.1  integrin beta-4 isoform X3

    UniProtKB/TrEMBL
    A0A0R7F1J7
    Related
    ENSOARP00020012649.2, ENSOART00020015291.2

  3. XM_042256360.2 → XP_042112294.1  integrin beta-4 isoform X2

    UniProtKB/TrEMBL
    A0A0R7F1J7
    Conserved Domains (3) summary
    smart00237
    Location:991 → 1085
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:1518 → 1608
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl00057
    Location:37 → 454
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. XM_042256359.2 → XP_042112293.1  integrin beta-4 isoform X1

    UniProtKB/TrEMBL
    A0A0R7F1J7
    Conserved Domains (3) summary
    smart00237
    Location:991 → 1085
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:1571 → 1661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl00057
    Location:37 → 454
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein Strain
Heading Accession and Version

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