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CYB5R3 cytochrome b5 reductase 3 [ Felis catus (domestic cat) ]

Gene ID: 101091382, updated on 17-Aug-2024

Summary

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Official Symbol
CYB5R3
Official Full Name
cytochrome b5 reductase 3
Primary source
VGNC:VGNC:83863
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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See CYB5R3 in Genome Data Viewer
Location:
chromosome: B4
Exon count:
9
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (135590834..135617319, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B4 NC_018729.3 (137953802..137982293, complement)

Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase delta interacting protein 3 Neighboring gene uncharacterized LOC102899157 Neighboring gene U12 minor spliceosomal RNA Neighboring gene uncharacterized LOC123386758 Neighboring gene uncharacterized LOC109501827 Neighboring gene U4 spliceosomal RNA Neighboring gene alpha 1,4-galactosyltransferase Neighboring gene uncharacterized LOC109501829 Neighboring gene ADP ribosylation factor GTPase activating protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b(5) reductase deficiency in cats. Jaffey JA, et al. J Vet Intern Med, 2019 Nov. PMID 31650629, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The 2 novel cytochrome b5 reductase [CYB5R3] variants reported in this article were associated with methemoglobinemia using clinical, biochemical, genomics, and in silico protein studies.
    Title: Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b(5) reductase deficiency in cats.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NADH-cytochrome b5 reductase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    135590834..135617319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_045062469.1 → XP_044918404.1  NADH-cytochrome b5 reductase 3

    UniProtKB/TrEMBL
    A0A1W7GKK0
    Conserved Domains (1) summary
    PLN02252
    Location:38 → 301
    PLN02252; nitrate reductase [NADPH]
Nucleotide Protein
Heading Accession and Version

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