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Tph2 tryptophan hydroxylase 2 [ Cavia porcellus (domestic guinea pig) ]

Gene ID: 100724594, updated on 8-Mar-2024

Summary

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Gene symbol
Tph2
Gene description
tryptophan hydroxylase 2
See related
Ensembl:ENSCPOG00000005406
Gene type
protein coding
RefSeq status
MODEL
Organism
Cavia porcellus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
Orthologs
human mouse all
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Genomic context

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See Tph2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947491.1 (64624965..64720676)
103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176410.1 (26573145..26668769, complement)

NW_026947491.1Genomic Context describing neighboring genes Neighboring gene RAB21, member RAS oncogene family Neighboring gene TBC1 domain family member 15 Neighboring gene thyrotropin releasing hormone degrading enzyme Neighboring gene uncharacterized LOC134477176

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tryptophan 5-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tryptophan 5-hydroxylase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCavPor4.1

Genomic

  1. NW_026947491.1 Reference mCavPor4.1

    Range
    64624965..64720676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003476021.5 → XP_003476069.1  tryptophan 5-hydroxylase 2

    UniProtKB/TrEMBL
    H0V5D7
    Related
    ENSCPOP00000004866.3
    Conserved Domains (3) summary
    TIGR01270
    Location:63 → 486
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    cd04929
    Location:65 → 138
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    pfam00351
    Location:153 → 483
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
Nucleotide Protein
Heading Accession and Version

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