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Actn1 actinin alpha 1 [ Cavia porcellus (domestic guinea pig) ]

Gene ID: 100721342, updated on 8-Mar-2024

Summary

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Gene symbol
Actn1
Gene description
actinin alpha 1
See related
Ensembl:ENSCPOG00000001107
Gene type
protein coding
RefSeq status
MODEL
Organism
Cavia porcellus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
Orthologs
human mouse all
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Genomic context

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See Actn1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947514.1 (32714550..32807607)
103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176399.1 (13460699..13553532, complement)

NW_026947514.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134474174 Neighboring gene DDB1 and CUL4 associated factor 5 Neighboring gene eukaryotic translation initiation factor 3 subunit I-like Neighboring gene uncharacterized LOC101788646 Neighboring gene ZFP36 ring finger protein like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle cell development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-actinin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCavPor4.1

Genomic

  1. NW_026947514.1 Reference mCavPor4.1

    Range
    32714550..32807607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063241077.1 → XP_063097147.1  alpha-actinin-1 isoform X7

  2. XM_003472376.5 → XP_003472424.1  alpha-actinin-1 isoform X4

    UniProtKB/TrEMBL
    A0A286XSM3
    Related
    ENSCPOP00000028282.1
    Conserved Domains (7) summary
    cd00014
    Location:145 → 249
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:750 → 839
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:395 → 622
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:32 → 130
    CH; Calponin homology (CH) domain
    pfam00435
    Location:634 → 733
    Spectrin; Spectrin repeat
    pfam08726
    Location:844 → 910
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:752 → 838
    EF-hand_7; EF-hand domain pair

  3. XM_003472374.4 → XP_003472422.1  alpha-actinin-1 isoform X5

    UniProtKB/TrEMBL
    H0UVG6
    Related
    ENSCPOP00000001002.2
    Conserved Domains (7) summary
    cd00014
    Location:145 → 249
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:750 → 817
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:395 → 622
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:32 → 130
    CH; Calponin homology (CH) domain
    pfam00435
    Location:634 → 733
    Spectrin; Spectrin repeat
    pfam08726
    Location:822 → 888
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:752 → 816
    EF-hand_7; EF-hand domain pair

  4. XM_003472375.4 → XP_003472423.1  alpha-actinin-1 isoform X6

    UniProtKB/TrEMBL
    A0A286XZY1
    Related
    ENSCPOP00000030855.1
    Conserved Domains (7) summary
    cd00014
    Location:145 → 249
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:750 → 812
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:395 → 622
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:32 → 130
    CH; Calponin homology (CH) domain
    pfam00435
    Location:634 → 733
    Spectrin; Spectrin repeat
    pfam08726
    Location:817 → 883
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:752 → 811
    EF-hand_7; EF-hand domain pair

  5. XM_063241072.1 → XP_063097142.1  alpha-actinin-1 isoform X1

  6. XM_063241073.1 → XP_063097143.1  alpha-actinin-1 isoform X2

  7. XM_063241074.1 → XP_063097144.1  alpha-actinin-1 isoform X3

  8. XM_063241076.1 → XP_063097146.1  alpha-actinin-1 isoform X1

Nucleotide Protein
Heading Accession and Version

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