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ATP13A2 ATPase cation transporting 13A2 [ Canis lupus familiaris (dog) ]

Gene ID: 100686975, updated on 17-Aug-2024

Summary

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Official Symbol
ATP13A2provided by VGNC
Official Full Name
ATPase cation transporting 13A2provided by VGNC
Primary source
VGNC:VGNC:38242
See related
Ensembl:ENSCAFG00845004285
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ATP13A2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
29
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (81842888..81861861)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (77733475..77752482)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (80680908..80699865)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (78595908..78614871)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (79612457..79631767)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA72 Neighboring gene peptidyl arginine deiminase 2 Neighboring gene uncharacterized LOC119870476 Neighboring gene succinate dehydrogenase complex iron sulfur subunit B Neighboring gene microfibril associated protein 2 Neighboring gene ciliary rootlet coiled-coil, rootletin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATP13A2 missense variant in Australian Cattle Dogs with late onset neuronal ceroid lipofuscinosis. Schmutz I, et al. Mol Genet Metab, 2019 May. PMID 30956123, Free PMC Article
  2. A one base pair deletion in the canine ATP13A2 gene causes exon skipping and late-onset neuronal ceroid lipofuscinosis in the Tibetan terrier. Wöhlke A, et al. PLoS Genet, 2011 Oct. PMID 22022275, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. All 3 dogs with late onset neuronal ceroid lipofuscinosis were homozygous for the missense variant of ATP13A2
    Title: ATP13A2 missense variant in Australian Cattle Dogs with late onset neuronal ceroid lipofuscinosis.
  2. ATP13A2 mutations have been described in familial Parkinson syndrome (PARK9). Tibetan terriers with these mutations provide a valuable model for a PARK9-linked disease and possibly for manganese toxicity in synucleinopathies
    Title: A one base pair deletion in the canine ATP13A2 gene causes exon skipping and late-onset neuronal ceroid lipofuscinosis in the Tibetan terrier.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables P-type ion transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome-lysosome fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of autophagosome size IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cation-transporting ATPase 13A2; polyamine-transporting ATPase 13A2
Names
ATPase 13A2
ATPase type 13A2
XP_038310833.1
XP_038326886.1
XP_038326887.1
XP_038326888.1
XP_038326889.1
XP_038326890.1
XP_038387762.1
XP_038387763.1
XP_038387764.1
XP_038387765.1
XP_038387766.1
XP_038452021.1
XP_038452022.1
XP_038452023.1
XP_038452024.1
XP_038452026.1
XP_038516106.1
XP_038516107.1
XP_038516108.1
XP_038516109.1
XP_038516110.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    81842888..81861861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038660178.1 → XP_038516106.1  polyamine-transporting ATPase 13A2 isoform X1

    UniProtKB/TrEMBL
    A0A8P0NHC0
    Related
    ENSCAFP00845006322.1, ENSCAFT00845008038.1
    Conserved Domains (1) summary
    TIGR01657
    Location:39 → 1118
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

  2. XM_038660181.1 → XP_038516109.1  polyamine-transporting ATPase 13A2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0MXD0
    Related
    ENSCAFP00845006400.1, ENSCAFT00845008147.1
    Conserved Domains (1) summary
    TIGR01657
    Location:39 → 1079
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

  3. XM_038660182.1 → XP_038516110.1  polyamine-transporting ATPase 13A2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0PU86, A0A8I3MXI5
    Related
    ENSCAFP00845006292.1, ENSCAFT00845007996.1
    Conserved Domains (1) summary
    TIGR01657
    Location:39 → 1049
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

  4. XM_038660180.1 → XP_038516108.1  polyamine-transporting ATPase 13A2 isoform X3

    UniProtKB/TrEMBL
    A0A8P0NHC0
    Conserved Domains (1) summary
    TIGR01657
    Location:39 → 1109
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

  5. XM_038660179.1 → XP_038516107.1  polyamine-transporting ATPase 13A2 isoform X2

    UniProtKB/TrEMBL
    A0A8P0NHC0
    Related
    ENSCAFP00845006271.1, ENSCAFT00845007963.1
    Conserved Domains (1) summary
    TIGR01657
    Location:39 → 1117
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    78595908..78614871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038470958.1 → XP_038326886.1  polyamine-transporting ATPase 13A2 isoform X1

    Conserved Domains (1) summary
    TIGR01657
    Location:39 → 1118
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

  2. XM_038470961.1 → XP_038326889.1  polyamine-transporting ATPase 13A2 isoform X4

    Conserved Domains (1) summary
    TIGR01657
    Location:39 → 1079
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

  3. XM_038470962.1 → XP_038326890.1  polyamine-transporting ATPase 13A2 isoform X5

    Conserved Domains (1) summary
    TIGR01657
    Location:39 → 1049
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

  4. XM_038470960.1 → XP_038326888.1  polyamine-transporting ATPase 13A2 isoform X3

    Conserved Domains (1) summary
    TIGR01657
    Location:39 → 1109
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

  5. XM_038470959.1 → XP_038326887.1  polyamine-transporting ATPase 13A2 isoform X2

    Conserved Domains (1) summary
    TIGR01657
    Location:39 → 1117
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    79612457..79631767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038596093.1 → XP_038452021.1  polyamine-transporting ATPase 13A2 isoform X1

  2. XM_038596096.1 → XP_038452024.1  polyamine-transporting ATPase 13A2 isoform X4

  3. XM_038596098.1 → XP_038452026.1  polyamine-transporting ATPase 13A2 isoform X5

  4. XM_038596095.1 → XP_038452023.1  polyamine-transporting ATPase 13A2 isoform X3

  5. XM_038596094.1 → XP_038452022.1  polyamine-transporting ATPase 13A2 isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    80680908..80699865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038531834.1 → XP_038387762.1  polyamine-transporting ATPase 13A2 isoform X1

    UniProtKB/TrEMBL
    A0A8P0NHC0

  2. XM_038531837.1 → XP_038387765.1  polyamine-transporting ATPase 13A2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0MXD0

  3. XM_038531838.1 → XP_038387766.1  polyamine-transporting ATPase 13A2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0PU86, A0A8I3MXI5

  4. XM_038531836.1 → XP_038387764.1  polyamine-transporting ATPase 13A2 isoform X3

    UniProtKB/TrEMBL
    A0A8P0NHC0

  5. XM_038531835.1 → XP_038387763.1  polyamine-transporting ATPase 13A2 isoform X2

    UniProtKB/TrEMBL
    A0A8P0NHC0

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    77733475..77752482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038454905.1 → XP_038310833.1  polyamine-transporting ATPase 13A2 isoform X6

    UniProtKB/TrEMBL
    A0A8P0NHC0
    Conserved Domains (1) summary
    TIGR01657
    Location:39 → 1166
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
Nucleotide Protein
Heading Accession and Version

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