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MIR4666A microRNA 4666a [ Homo sapiens (human) ]

Gene ID: 100616308, updated on 17-Sep-2024

Summary

Official Symbol
MIR4666Aprovided by HGNC
Official Full Name
microRNA 4666aprovided by HGNC
Primary source
HGNC:HGNC:41750
See related
Ensembl:ENSG00000266174 miRBase:MI0017296; AllianceGenome:HGNC:41750
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR4666; hsa-mir-4666a
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR4666A in Genome Data Viewer
Location:
1q42.13
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228462074..228462152)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227650586..227650664)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228649775..228649853)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:228645697-228646283 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:228646284-228646869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2695 Neighboring gene H2A clustered histone 25 Neighboring gene H2B clustered histone 26 Neighboring gene H2B clustered histone 27, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228658552-228659062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228663712-228664547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228673961-228674822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228674823-228675683 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228675801-228676529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228676530-228677257 Neighboring gene Sharpr-MPRA regulatory region 4602 Neighboring gene ring finger protein 187 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228680575-228681520

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039812.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL139288
    Related
    ENST00000580160.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    228462074..228462152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654708.1 Reference GRCh38.p14 PATCHES

    Range
    53273..53351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    227650586..227650664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)