MIR499B microRNA 499b [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR499Bprovided by HGNC
Official Full Name: microRNA 499bprovided by HGNC
Primary source: HGNC:HGNC:41640
See related: Ensembl:ENSG00000283441 miRBase:MI0017396; AllianceGenome:HGNC:41640
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIR499A; hsa-mir-499b
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 20q11.22

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (34990400..34990472, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (36711040..36711112, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (33578203..33578275, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis.
Title: Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis.
MiR-499b-5p inhibits cervical cancer cell proliferation and induces apoptosis by targeting the Notch1 signaling pathway.
Title: MiR-499b-5p inhibits cervical cancer cell proliferation and induces apoptosis by targeting the Notch1 signaling pathway.
MicroRNA variants in endometriosis and its severity.
Title: MicroRNA variants in endometriosis and its severity.
Diagnostic value of circulating miR-208b and miR-499 in peripheral blood of patients with acute myocardial infarction.
Title: Diagnostic value of circulating miR-208b and miR-499 in peripheral blood of patients with acute myocardial infarction.
Role of miRNA-499-5p in patients with atrial fibrillation and heart failure.
Title: Role of miRNA-499-5p in patients with atrial fibrillation and heart failure.
Data found that increased plasma levels of miR-208b and miR-499 were significantly associated with coronary artery disease (CAD) severity. Plasma miR-208b and miR-499 can act as potential biomarkers for estimating the severity of CAD.
Title: Plasma miR-208b and miR-499: Potential Biomarkers for Severity of Coronary Artery Disease.
Results find that miR-499 is one of the miRNA regulating PDCD4 expression in head and neck squamous cell carcinoma. Furthermore, the efficiency of miR-499 targeting PDCA4 is increased by the presence of both an intact miR-21 binding site and high levels of miR-21.
Title: MicroRNA (miRNA)-to-miRNA Regulation of Programmed Cell Death 4 (PDCD4).
The present study indicates that miRNA-499 rs3746444 polymorphism is associated with inflammatory arthritis susceptibility. However, there is lack of association between miRNA-146 rs2910164 polymorphism and inflammatory arthritis susceptibility. But, we also find miRNA-146 rs2910164 and miRNA-499 rs3746444 polymorphism are associated with inflammatory arthritis in Middle East.
Title: Association of rs2910164 Polymorphism in miRNA-146 and rs3746444 Polymorphism in miRNA-499 with Inflammatory Arthritis: A Meta-Analysis.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.