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BIVM-ERCC5 BIVM-ERCC5 readthrough [ Homo sapiens (human) ]

Gene ID: 100533467, updated on 2-Nov-2024

Summary

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Official Symbol
BIVM-ERCC5provided by HGNC
Official Full Name
BIVM-ERCC5 readthroughprovided by HGNC
Primary source
HGNC:HGNC:43690
See related
Ensembl:ENSG00000270181 AllianceGenome:HGNC:43690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERCC5-202
Summary
This locus represents naturally occurring read-through transcription between the neighboring BIVM (basic, immunoglobulin-like variable motif containing) and ERCC5 (excision repair cross-complementing rodent repair deficiency, complementation group 5) genes on chromosome 13. The read-through transcript encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in duodenum (RPKM 14.2), spleen (RPKM 14.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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See BIVM-ERCC5 in Genome Data Viewer
Location:
13q33.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (102807146..102875995)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (102025322..102094203)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (103459496..103528345)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370337 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:103425891-103426568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:103426569-103427246 Neighboring gene testis expressed 30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5486 Neighboring gene protein O-glucosyltransferase 2 Neighboring gene NANOG hESC enhancer GRCh37_chr13:103478160-103478661 Neighboring gene basic, immunoglobulin-like variable motif containing Neighboring gene ReSE screen-validated silencer GRCh37_chr13:103485696-103485895 Neighboring gene H3K27ac hESC enhancers GRCh37_chr13:103497312-103498136 and GRCh37_chr13:103498137-103498959 Neighboring gene RNY5 pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5487 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:103518038-103519237 Neighboring gene ERCC excision repair 5, endonuclease Neighboring gene methyltransferase like 21E, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7975 Neighboring gene solute carrier family 10 member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  2. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
  3. K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors. Waltho A, et al. Life Sci Alliance, 2024 Aug. PMID 38803224, Free PMC Article
  4. Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Golkowski M, et al. Mol Cell, 2023 Mar 2. PMID 36736316, Free PMC Article
  5. Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability. Gall-Duncan T, et al. Cell, 2023 Oct 26. PMID 37827155, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough BIVM-ERCC5

Included genes: ERCC5, BIVM

Homology

General protein information

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Preferred Names
BIVM-ERCC5 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204425.2 → NP_001191354.2  BIVM-ERCC5 protein

    Status: REVIEWED

    Source sequence(s)
    AL157769, LM994822
    UniProtKB/TrEMBL
    A0A090J7P6, Q59FZ7, R4GMW8
    Related
    ENSP00000491742.1, ENST00000639435.1
    Conserved Domains (1) summary
    TIGR00600
    Location:484 → 1483
    rad2; DNA excision repair protein (rad2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    102807146..102875995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    102025322..102094203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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