lgr5.L leucine-rich repeat containing G protein-coupled receptor 5 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: lgr5.L
Official Full Name: leucine-rich repeat containing G protein-coupled receptor 5 L homeolog
Primary source: Xenbase:XB-GENE-11536385
Locus tag: XELAEV_18017557mg
See related: EnsemblRapid:ENSXLAG00005002719 AllianceGenome:Xenbase:XB-GENE-11536385
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: lgr5; lgr5a; lgr5-a
Summary: Predicted to enable transmembrane signaling receptor activity. Predicted to act upstream of or within positive regulation of canonical Wnt signaling pathway. Predicted to be located in plasma membrane and trans-Golgi network membrane. Orthologous to human LGR5 (leucine rich repeat containing G protein-coupled receptor 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3L

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (66542584..66653523)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (52100640..52212106)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
NOT enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within activation of adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat-containing G-protein coupled receptor 5A

Names: leucine-rich repeat-containing G protein-coupled receptor 5; leucine-rich repeat-containing G-protein coupled receptor 5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199223.1 → NP_001186152.1 leucine-rich repeat-containing G-protein coupled receptor 5A precursor

See identical proteins and their annotated locations for NP_001186152.1

Status: PROVISIONAL

Source sequence(s)

GU296021

UniProtKB/Swiss-Prot

E5DHB5

UniProtKB/TrEMBL

A0A974HST2

Related

ENSXLAP00005008063.1, ENSXLAT00005008186.1

Conserved Domains (7) summary

smart00013
Location:32 → 61

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:160 → 406

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:304 → 326

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:65 → 88

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:571 → 816

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:185 → 243

LRR_8; Leucine rich repeat

cl21561
Location:562 → 738

7tm_4; Olfactory receptor