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EGFR epidermal growth factor receptor [ Felis catus (domestic cat) ]

Gene ID: 100510799, updated on 11-Apr-2024

Summary

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Official Symbol
EGFR
Official Full Name
epidermal growth factor receptor
Primary source
VGNC:VGNC:61759
See related
EnsemblRapid:ENSFCTG00005011590
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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See EGFR in Genome Data Viewer
Location:
chromosome: A2
Exon count:
29
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) A2 NC_058369.1 (69756757..69967695)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) A2 NC_018724.3 (70930530..71143327)

Chromosome A2 - NC_058369.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111557280 Neighboring gene uncharacterized LOC123381228 Neighboring gene uncharacterized LOC123383814 Neighboring gene LanC like glutathione S-transferase 2 Neighboring gene VOPP1 WW domain binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Felis catus papillomavirus type 2 E6 oncogene enhances mitogen-activated protein kinases and Akt activation but not EGFR expression in an in vitro feline model of viral pathogenesis. Altamura G, et al. Vet Microbiol, 2016 Nov 15. PMID 27771077
  2. Epidermal growth factor improves developmental competence and embryonic quality of singly cultured domestic cat embryos. Thongkittidilok C, et al. J Reprod Dev, 2015. PMID 25985792, Free PMC Article
  3. Studies on the inhibition of feline EGFR in squamous cell carcinoma: enhancement of radiosensitivity and rescue of resistance to small molecule inhibitors. Bergkvist GT, et al. Cancer Biol Ther, 2011 Jun 1. PMID 21464610
  4. Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation. Dai X, et al. Virulence, 2020 Dec. PMID 32877289, Free PMC Article
  5. Endogenous endothelin 1 mediates angiotensin II-induced hypertrophy in electrically paced cardiac myocytes through EGFR transactivation, reactive oxygen species and NHE-1. Correa MV, et al. Pflugers Arch, 2014 Sep. PMID 24327206

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation.
    Title: Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation.
  2. This study demonstrated by real-time quantitative PCR on epidermal growth factor receptor (EGFR) transcripts and WB that activation of these signaling routes is independent from EGFR differential gene expression, total protein levels or phosphorylation.
    Title: Felis catus papillomavirus type 2 E6 oncogene enhances mitogen-activated protein kinases and Akt activation but not EGFR expression in an in vitro feline model of viral pathogenesis.
  3. Data suggest that EGFR is expressed in cat preimplantation embryos following in vitro oocyte maturation/in vitro fertilization; supplementation with recombinant human EGF up-regulates EGFR expression and enhances ectogenesis.
    Title: Epidermal growth factor improves developmental competence and embryonic quality of singly cultured domestic cat embryos.
  4. we propose that endogenous ET-1 mediates the hypertrophic response to Ang II by a mechanism that involves EGFR transactivation and redox-dependent activation...in adult cardiomyocytes
    Title: Endogenous endothelin 1 mediates angiotensin II-induced hypertrophy in electrically paced cardiac myocytes through EGFR transactivation, reactive oxygen species and NHE-1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058369.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    69756757..69967695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006929086.4 → XP_006929148.2  epidermal growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A337S424
    Conserved Domains (4) summary
    smart00261
    Location:552 → 598
    FU; Furin-like repeats
    cd00064
    Location:231 → 274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05108
    Location:704 → 1016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:634 → 677
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases

  2. XM_045052148.1 → XP_044908083.1  epidermal growth factor receptor isoform X2

    UniProtKB/TrEMBL
    M3WMN1
    Related
    ENSFCTP00005022075.1, ENSFCTT00005032932.1
    Conserved Domains (4) summary
    smart00261
    Location:499 → 545
    FU; Furin-like repeats
    cd00064
    Location:178 → 221
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:581 → 624
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
Nucleotide Protein
Heading Accession and Version

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