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SOX21-AS1 SOX21 antisense divergent transcript 1 [ Homo sapiens (human) ]

Gene ID: 100507533, updated on 16-Mar-2024

Summary

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Official Symbol
SOX21-AS1provided by HGNC
Official Full Name
SOX21 antisense divergent transcript 1provided by HGNC
Primary source
HGNC:HGNC:39807
See related
Ensembl:ENSG00000227640 AllianceGenome:HGNC:39807
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in stomach (RPKM 6.7), skin (RPKM 3.6) and 3 other tissues See more
Orthologs
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Genomic context

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See SOX21-AS1 in Genome Data Viewer
Location:
13q32.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (94712716..94715945)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (93916221..93919442)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (95364970..95368199)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95353695-95354372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95354373-95355048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95357234-95357738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95357739-95358243 Neighboring gene VISTA enhancer hs488 Neighboring gene long intergenic non-protein coding RNA 391 Neighboring gene RNA, 7SL, cytoplasmic 585, pseudogene Neighboring gene uncharacterized LOC112268114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95365523-95366024 Neighboring gene SRY-box transcription factor 21 Neighboring gene uncharacterized LOC101927284 Neighboring gene ribosomal protein L21 pseudogene 112 Neighboring gene bromodomain containing 7 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Downregulation of SOX21-AS1 Alleviated Cisplatin Resistance in Cervical Cancer Through Epithelial-Mesenchymal Transition Inhibition. Tian J, et al. Rejuvenation Res, 2022 Oct. PMID 36039935
  2. SRY-Box 21 Antisense RNA 1 Knockdown Diminishes Amyloid Beta(25-35)-Induced Neuronal Damage by miR-132/PI3K/AKT Pathway. Gu F, et al. Neurochem Res, 2021 Sep. PMID 34146195
  3. LncRNA SOX21-AS1 Promotes the Growth and Invasiveness of Osteosarcoma Cells Through miR-7-5p/IRS2 Regulatory Network. Chen H, et al. Arch Med Res, 2021 Apr. PMID 33341286
  4. Long non-coding RNA SOX21-AS1 enhances the stemness of breast cancer cells via the Hippo pathway. Li L, et al. FEBS Open Bio, 2021 Jan. PMID 33103351, Free PMC Article
  5. Aberrant Methylation of the SOX21-AS1 Promoter Region Promotes Gene Expression and Its Clinical Value in Cervical Cancer. Du P, et al. Reprod Sci, 2021 Feb. PMID 33095426

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA SOX21-AS1: A potential tumor oncogene in human cancers.
    Title: Long non-coding RNA SOX21-AS1: A potential tumor oncogene in human cancers.
  2. SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression via up-regulation of SOX21.
    Title: SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression via up-regulation of SOX21.
  3. Downregulation of SOX21-AS1 Alleviated Cisplatin Resistance in Cervical Cancer Through Epithelial-Mesenchymal Transition Inhibition.
    Title: Downregulation of SOX21-AS1 Alleviated Cisplatin Resistance in Cervical Cancer Through Epithelial-Mesenchymal Transition Inhibition.
  4. Long non-coding RNA SOX21-AS1 modulates lung cancer progress upon microRNA miR-24-3p/PIM2 axis.
    Title: Long non-coding RNA SOX21-AS1 modulates lung cancer progress upon microRNA miR-24-3p/PIM2 axis.
  5. Long non-coding RNA SOX21-AS1 enhances the stemness of breast cancer cells via the Hippo pathway.
    Title: Long non-coding RNA SOX21-AS1 enhances the stemness of breast cancer cells via the Hippo pathway.
  6. Aberrant Methylation of the SOX21-AS1 Promoter Region Promotes Gene Expression and Its Clinical Value in Cervical Cancer.
    Title: Aberrant Methylation of the SOX21-AS1 Promoter Region Promotes Gene Expression and Its Clinical Value in Cervical Cancer.
  7. SRY-Box 21 Antisense RNA 1 Knockdown Diminishes Amyloid Beta25-35-Induced Neuronal Damage by miR-132/PI3K/AKT Pathway.
    Title: SRY-Box 21 Antisense RNA 1 Knockdown Diminishes Amyloid Beta(25-35)-Induced Neuronal Damage by miR-132/PI3K/AKT Pathway.
  8. Long noncoding RNA SOX21-AS1 regulates the progression of triple-negative breast cancer through regulation of miR-520a-5p/ORMDL3 axis.
    Title: Long noncoding RNA SOX21-AS1 regulates the progression of triple-negative breast cancer through regulation of miR-520a-5p/ORMDL3 axis.
  9. LncRNA SOX21-AS1 Promotes the Growth and Invasiveness of Osteosarcoma Cells Through miR-7-5p/IRS2 Regulatory Network.
    Title: LncRNA SOX21-AS1 Promotes the Growth and Invasiveness of Osteosarcoma Cells Through miR-7-5p/IRS2 Regulatory Network.
  10. SOX21-AS1 modulates neuronal injury of MMP(+)-treated SH-SY5Y cells via targeting miR-7-5p and inhibiting IRS2.
    Title: SOX21-AS1 modulates neuronal injury of MMP(+)-treated SH-SY5Y cells via targeting miR-7-5p and inhibiting IRS2.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • SOX21 antisense RNA 1 (head to head)
  • SOX21 antisense RNA 1 (non-protein coding)

Clone Names

  • FLJ30897

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_046514.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137061
    Related
    ENST00000438290.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    94712716..94715945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    93916221..93919442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases