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LIFR-AS1 LIFR antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 100506495, updated on 10-Oct-2023

Summary

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Official Symbol
LIFR-AS1provided by HGNC
Official Full Name
LIFR antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:43600
See related
Ensembl:ENSG00000244968 AllianceGenome:HGNC:43600
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in thyroid (RPKM 1.5), brain (RPKM 1.4) and 23 other tissues See more
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Genomic context

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See LIFR-AS1 in Genome Data Viewer
Location:
5p13.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (38556786..38671216)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (38805863..38920283)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (38556888..38671318)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene EGF like, fibronectin type III and laminin G domains Neighboring gene uncharacterized LOC105374732 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:38463193-38464392 Neighboring gene uncharacterized LOC124900964 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:38466368-38467567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:38468935-38469806 Neighboring gene LIF receptor subunit alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:38556889-38557672 Neighboring gene uncharacterized LOC105374735 Neighboring gene microRNA 3650 Neighboring gene Sharpr-MPRA regulatory region 9095 Neighboring gene OSMR divergent transcript Neighboring gene long intergenic non-protein coding RNA 1265 Neighboring gene transmembrane protein 126A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer. Song P, et al. Clin Epigenetics, 2022 Oct 31. PMID 36316703, Free PMC Article
  2. LncRNA LIFR-AS1 overexpression suppressed the progression of serous ovarian carcinoma. Liu F, et al. J Clin Lab Anal, 2022 Aug. PMID 35778954, Free PMC Article
  3. Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers. Bai Z, et al. Biomed Res Int, 2022. PMID 35071590, Free PMC Article
  4. M(6)A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling. Chen JQ, et al. Cell Cycle, 2021 Dec. PMID 34658294, Free PMC Article
  5. High long non-coding LIFR-AS1 expression correlates with poor survival in gastric carcinoma. Wang HF, et al. Eur Rev Med Pharmacol Sci, 2020 May. PMID 32495872

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer.
    Title: Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer.
  2. LncRNA LIFR-AS1 overexpression suppressed the progression of serous ovarian carcinoma.
    Title: LncRNA LIFR-AS1 overexpression suppressed the progression of serous ovarian carcinoma.
  3. Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers.
    Title: Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers.
  4. Long non-coding RNA LIFR-AS1 suppressed the proliferation, angiogenesis, migration and invasion of papillary thyroid cancer cells via the miR-31-5p/SIDT2 axis.
    Title: Long non-coding RNA LIFR-AS1 suppressed the proliferation, angiogenesis, migration and invasion of papillary thyroid cancer cells via the miR-31-5p/SIDT2 axis.
  5. M(6)A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling.
    Title: M(6)A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling.
  6. Long noncoding RNA LIFR-AS1 suppresses proliferation, migration and invasion and promotes apoptosis through modulating miR-4262/NF-kappaB pathway in glioma.
    Title: Long noncoding RNA LIFR-AS1 suppresses proliferation, migration and invasion and promotes apoptosis through modulating miR-4262/NF-κB pathway in glioma.
  7. lncRNA LIFRAS1 inhibits gastric carcinoma cell proliferation, migration and invasion by sponging miR4698.
    Title: lncRNA LIFR‑AS1 inhibits gastric carcinoma cell proliferation, migration and invasion by sponging miR‑4698.
  8. High long non-coding LIFR-AS1 expression correlates with poor survival in gastric carcinoma.
    Title: High long non-coding LIFR-AS1 expression correlates with poor survival in gastric carcinoma.
  9. LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer.
    Title: LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer.
  10. LIFR-AS1 serves as a competitive endogenous RNA for miR-29a to inhibit its expression and up-regulate downstream target TNFAIP3 expression, finally modulating the resistance of colorectal cancer to pohotodynamic therapy.
    Title: Functional role of a long non-coding RNA LIFR-AS1/miR-29a/TNFAIP3 axis in colorectal cancer resistance to pohotodynamic therapy.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • CTD-2196P11.1
  • LIFR antisense RNA 1 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_103553.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC010425, AC091823
    Related
    ENST00000500733.6

  2. NR_103554.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains multiple alternate 3' exons, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AC091823, BC045578

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    38556786..38671216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    38805863..38920283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases