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itgb3 integrin subunit beta 3 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100498495, updated on 4-Nov-2024

Summary

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Official Symbol
itgb3provided by Xenbase
Official Full Name
integrin subunit beta 3provided by Xenbase
Primary source
Xenbase:XB-GENE-1009964
See related
Ensembl:ENSXETG00000019163 AllianceGenome:Xenbase:XB-GENE-1009964
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
cd61; gp3a
Summary
Predicted to act upstream of or within cell adhesion and integrin-mediated signaling pathway. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See itgb3 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
15
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 10 NC_030686.2 (15348858..15371515, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 10 NC_030686.1 (8953279..8975331)

Chromosome 10 - NC_030686.2Genomic Context describing neighboring genes Neighboring gene methyltransferase 2B, tRNA N3-cytidine Neighboring gene sprT-like domain-containing protein Spartan Neighboring gene reprimo-like Neighboring gene golgi SNAP receptor complex member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrin beta-3
Names
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030686.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    15348858..15371515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002942355.3 → XP_002942401.2  integrin beta-3

    UniProtKB/TrEMBL
    A0A6I8QUX8, A0A7D9NM40
    Related
    ENSXETP00000073415.1, ENSXETT00000103303.2
    Conserved Domains (5) summary
    smart00187
    Location:32 → 456
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:629 → 712
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:739 → 781
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam12785
    Location:538 → 650
    VESA1_N; Variant erythrocyte surface antigen-1
    pfam18372
    Location:458 → 487
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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