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adamts8 ADAM metallopeptidase with thrombospondin type 1 motif 8 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100497759, updated on 4-Nov-2024

Summary

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Official Symbol
adamts8provided by Xenbase
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 8provided by Xenbase
Primary source
Xenbase:XB-GENE-994782
See related
AllianceGenome:Xenbase:XB-GENE-994782
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Predicted to act upstream of or within extracellular matrix organization and proteolysis. Predicted to be located in collagen-containing extracellular matrix and extracellular region. Orthologous to human ADAMTS8 (ADAM metallopeptidase with thrombospondin type 1 motif 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See adamts8 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 7 NC_030683.2 (70063266..70094026)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 7 NC_030683.1 (46882360..46911387, complement)

Chromosome 7 - NC_030683.2Genomic Context describing neighboring genes Neighboring gene sorting nexin 19 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 15 Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene suppression of tumorigenicity 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030683.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    70063266..70094026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002940639.4 → XP_002940685.2  A disintegrin and metalloproteinase with thrombospondin motifs 8

    UniProtKB/TrEMBL
    A0A8J0QSE7
    Conserved Domains (5) summary
    smart00209
    Location:543 → 595
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:236 → 441
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:33 → 142
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:704 → 823
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam17771
    Location:455 → 527
    ADAM_CR_2; ADAM cysteine-rich domain

RNA

  1. XR_004223595.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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