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hlcs holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100492512, updated on 4-Nov-2024

Summary

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Official Symbol
hlcsprovided by Xenbase
Official Full Name
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)provided by Xenbase
Primary source
Xenbase:XB-GENE-1009304
See related
Ensembl:ENSXETG00000013028 AllianceGenome:Xenbase:XB-GENE-1009304
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable biotin--[biotin carboxyl-carrier protein] ligase activity. Predicted to act upstream of or within protein modification process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See hlcs in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (12678145..12770923)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (8635463..8725909)

Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class P Neighboring gene ripply transcriptional repressor 3 Neighboring gene SIM bHLH transcription factor 2 Neighboring gene claudin 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables biotin--[biotin carboxyl-carrier protein] ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables biotin--[biotin carboxyl-carrier protein] ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein modification process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
biotin--protein ligase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    12678145..12770923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004912115.4 → XP_004912172.1  biotin--protein ligase

    See identical proteins and their annotated locations for XP_004912172.1

    UniProtKB/TrEMBL
    A0A6I8QGT9, F6QNE8
    Related
    ENSXETP00000114644.1, ENSXETT00000121585.1
    Conserved Domains (1) summary
    cd16442
    Location:595 → 773
    BPL; biotin protein ligase

  2. XM_004912116.4 → XP_004912173.1  biotin--protein ligase

    See identical proteins and their annotated locations for XP_004912173.1

    UniProtKB/TrEMBL
    A0A6I8QGT9, F6QNE8
    Related
    ENSXETP00000028542.3, ENSXETT00000028542.4
    Conserved Domains (1) summary
    cd16442
    Location:595 → 773
    BPL; biotin protein ligase

  3. XM_004912117.4 → XP_004912174.1  biotin--protein ligase

    See identical proteins and their annotated locations for XP_004912174.1

    UniProtKB/TrEMBL
    A0A6I8QGT9, F6QNE8
    Conserved Domains (1) summary
    cd16442
    Location:595 → 773
    BPL; biotin protein ligase

RNA

  1. XR_004221203.1 RNA Sequence

  2. XR_004221204.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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