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adamts2 ADAM metallopeptidase with thrombospondin type 1 motif 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100492431, updated on 4-Nov-2024

Summary

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Official Symbol
adamts2provided by Xenbase
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 2provided by Xenbase
Primary source
Xenbase:XB-GENE-492342
See related
Ensembl:ENSXETG00000003829 AllianceGenome:Xenbase:XB-GENE-492342
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to act upstream of or within extracellular matrix organization and proteolysis. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome dermatosparaxis type. Orthologous to human ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See adamts2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
22
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (31153457..31304900)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (21972172..22095302)

Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A0 Neighboring gene CDC like kinase 1 Neighboring gene phosphatidylinositol polyphosphate 5-phosphatase type IV-like Neighboring gene phosphatidylinositol polyphosphate 5-phosphatase type IV-like Neighboring gene glutamine-fructose-6-phosphate transaminase 2 Neighboring gene family with sequence similarity 13 member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    31153457..31304900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012959749.3 → XP_012815203.2  A disintegrin and metalloproteinase with thrombospondin motifs 2

    UniProtKB/TrEMBL
    A0A6I8QFJ1, A0A8J0SAB1
    Related
    ENSXETP00000071154.2, ENSXETT00000094843.2
    Conserved Domains (6) summary
    smart00209
    Location:535 → 586
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:238 → 438
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:694 → 808
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:40 → 181
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:453 → 522
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:889 → 946
    TSP1_ADAMTS; Thrombospondin type 1 domain
Nucleotide Protein Strain
Heading Accession and Version

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