pdx1 pancreatic and duodenal homeobox 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: pdx1provided by Xenbase
Official Full Name: pancreatic and duodenal homeobox 1provided by Xenbase
Primary source: Xenbase:XB-GENE-483331
See related: Ensembl:ENSXETG00000011787 AllianceGenome:Xenbase:XB-GENE-483331
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: ipf1; STF-1; pdx-1; XlHbox8; XlHbox-8
Summary: Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in endocytic recycling and endocytosis. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be active in clathrin-coated vesicle and cytosol. Is expressed in endoderm. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis 1; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	2	NC_030678.2 (155135126..155160424, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	2	NC_030678.1 (152173455..152198585, complement)

Chromosome 2 - NC_030678.2 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain