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lamc2 laminin subunit gamma 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100489162, updated on 4-Nov-2024

Summary

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Official Symbol
lamc2provided by Xenbase
Official Full Name
laminin subunit gamma 2provided by Xenbase
Primary source
Xenbase:XB-GENE-990048
See related
Ensembl:ENSXETG00000024668 AllianceGenome:Xenbase:XB-GENE-990048
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to be located in basement membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See lamc2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
23
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (100003616..100028620, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (89791228..89815791, complement)

Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene neutrophil cytosolic factor 2 Neighboring gene SMG7 nonsense mediated mRNA decay factor Neighboring gene nicotinamide nucleotide adenylyltransferase 2 Neighboring gene laminin subunit gamma 1 Neighboring gene DEAH-box helicase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Component Evidence Code Pubs
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
laminin subunit gamma-2
Names
laminin, gamma 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    100003616..100028620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002937367.5 → XP_002937413.3  laminin subunit gamma-2

    UniProtKB/TrEMBL
    A0A6I8Q9Q7
    Related
    ENSXETP00000065239.2, ENSXETT00000089373.2
    Conserved Domains (7) summary
    smart00180
    Location:84 → 128
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    COG1196
    Location:636 → 1029
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00055
    Location:569 → 608
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00052
    Location:247 → 377
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:514 → 558
    Laminin_EGF; Laminin EGF domain
    NF033759
    Location:409 → 608
    exchanger_TraA; outer membrane exchange protein TraA
    cl21504
    Location:29 → 84
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Nucleotide Protein Strain
Heading Accession and Version

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