U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SRY sex determining region Y [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100328958, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
SRY
Gene description
sex determining region Y
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SRY in Genome Data Viewer
Location:
chromosome: Un
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026257262.1 (18387..19010)

NW_026257262.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC127485634

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NW_026257262 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CRISPR/Cas9-mediated mosaic mutation of SRY gene induces hermaphroditism in rabbits. Song Y, et al. Biosci Rep, 2018 Apr 27. PMID 29439141, Free PMC Article
  2. Extensive gene conversion drives the concerted evolution of paralogous copies of the SRY gene in European rabbits. Geraldes A, et al. Mol Biol Evol, 2010 Nov. PMID 20525900, Free PMC Article
  3. High levels of nucleotide diversity in the European rabbit (Oryctolagus cuniculus) SRY gene. Geraldes A, et al. Anim Genet, 2005 Aug. PMID 16026347
  4. Mutation of the Sp1 binding site in the 5' flanking region of SRY causes sex reversal in rabbits. Song Y, et al. Oncotarget, 2017 Jun 13. PMID 28445127, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRISPR/Cas9-mediated mosaic mutation of SRY gene induces hermaphroditism in rabbits.
    Title: CRISPR/Cas9-mediated mosaic mutation of SRY gene induces hermaphroditism in rabbits.
  2. our study demonstrates that Sp1 is a major regulator in SRY gene transcription, and mutations of the Sp1 binding sites (Sp1-B and Sp1-C) in the 5' flanking region of SRY induce sex reversal in rabbits
    Title: Mutation of the Sp1 binding site in the 5' flanking region of SRY causes sex reversal in rabbits.
  3. Gene conversion is a general feature of the evolution of the mammalian Y chromosome.
    Title: Extensive gene conversion drives the concerted evolution of paralogous copies of the SRY gene in European rabbits.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in male sex determination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
sex-determining region Y protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171148.1 → NP_001164619.1  sex-determining region Y protein

    See identical proteins and their annotated locations for NP_001164619.1

    Status: PROVISIONAL

    Source sequence(s)
    AY785433
    UniProtKB/TrEMBL
    Q49KM0
    Conserved Domains (2) summary
    cd01388
    Location:46 → 117
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam12336
    Location:116 → 175
    SOXp; SOX transcription factor

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NW_026257262.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    18387..19010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.