MIR718 microRNA 718 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR718provided by HGNC
Official Full Name: microRNA 718provided by HGNC
Primary source: HGNC:HGNC:37317
See related: Ensembl:ENSG00000284286 MIM:300929; miRBase:MI0012489; AllianceGenome:HGNC:37317
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: hsa-mir-718
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: Xq28

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (154019920..154019989, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (152293601..152293670, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (153285371..153285440, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-718 may mediate the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells.
Title: MiR-718 mediates the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells.
The present study strongly suggests that miR-718 inhibits papillary thyroid cancer cell proliferation, metastasis, and glucose metabolism...through PDPK1
Title: miR-718 is involved in malignancy of papillary thyroid cancer through repression of PDPK1.
We demonstrated that expression of PTEN and miR-718 were significantly correlated in patients with gastric cancer. Low expression of PTEN and high level of miR-718 were notably associated with a lower 5-year overall survival rate. Both PTEN and miR-718 were identified as prognostic factors of gastric cancer.
Title: High miR-718 Suppresses Phosphatase and Tensin Homolog (PTEN) Expression and Correlates to Unfavorable Prognosis in Gastric Cancer.
miR-718 acts as a tumor suppressive microRNA in hepatocellular carcinoma via regulating the expression of EGR3, which may provide a new diagnostic marker and treatment target for HCC
Title: Involvement of microRNA-718, a new regulator of EGR3, in regulation of malignant phenotype of HCC cells.
Plasma miRNA-718 is downregulated in ESCC patients and might serve as a potential diagnostic marker for ESCC.
Title: Predictive value of plasma miRNA-718 for esophageal squamous cell carcinoma.
this study identified HOXB8 as a potential target gene of miR-718, and its upregulation was associated with poor prognosis in hepatocellular carcinoma.
Title: Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation.
the role of MiR-718 in the regulation of VEGF in ovarian cancer
Title: MiR-718 represses VEGF and inhibits ovarian cancer cell progression.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

ECD04883 (e-PCR)
- UniSTS:285953

G65801 (e-PCR)
- UniSTS:166814

ECD01941 (e-PCR)
- UniSTS:283042

REN88550 (e-PCR)
- UniSTS:413348

REN88551 (e-PCR)
- UniSTS:413349

REN88552 (e-PCR)
- UniSTS:413350

REN88553 (e-PCR)
- UniSTS:413351

REN88554 (e-PCR)
- UniSTS:413352

REN88555 (e-PCR)
- UniSTS:413353

REN88556 (e-PCR)
- UniSTS:413354

REN88557 (e-PCR)
- UniSTS:413355

REN88558 (e-PCR)
- UniSTS:413356

REN88559 (e-PCR)
- UniSTS:413357

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.